hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05924.1
Complex Portal: CPX-21060
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| COL13A1 | Collagen alpha-1(XIII) chain (COLXIIIA1) | 5 | UniProt NCBI |
| PLOD3 | Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)] | 5 | UniProt NCBI |
| COLGALT2 | Procollagen galactosyltransferase 2 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 2) (ColGalT 2) (Glycosyltransferase 25 family member 2) (Hydroxylysine galactosyltransferase 2) | 5 | UniProt NCBI |
| DOK1 | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | 5 | UniProt NCBI |
| COL9A2 | Collagen alpha-2(IX) chain | 5 | UniProt NCBI |
| COL4A2 | Collagen alpha-2(IV) chain [Cleaved into: Canstatin] | 5 | UniProt NCBI |
| ODF2 | Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) | 5 | UniProt NCBI |
| COL9A3 | Collagen alpha-3(IX) chain | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1650814 | 8.92163224206e-12 | 0.75 | PLOD3 COL13A1 COL4A2 COL9A2 COL9A3 COLGALT2 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-1474290 | 6.83069269837e-11 | 0.75 | PLOD3 COL13A1 COL4A2 COL9A2 COL9A3 COLGALT2 | Collagen formation |
| REAC:R-HSA-1474244 | 7.83665840219e-08 | 0.75 | PLOD3 COL13A1 COL4A2 COL9A2 COL9A3 COLGALT2 | Extracellular matrix organization |
| REAC:R-HSA-8948216 | 2.13574543247e-07 | 0.5 | COL4A2 COL9A3 COL13A1 COL9A2 | Collagen chain trimerization |
| KEGG:04974 | 1.5542243847e-06 | 0.5 | COL4A2 COL9A3 COL13A1 COL9A2 | Protein digestion and absorption |
| REAC:R-HSA-1442490 | 1.64433766616e-06 | 0.5 | COL4A2 COL9A3 COL13A1 COL9A2 | Collagen degradation |
| GO:0030198 | 3.34323030556e-06 | 0.75 | PLOD3 COL13A1 COL4A2 COL9A2 COL9A3 COLGALT2 | extracellular matrix organization |
| GO:0043062 | 3.34323030556e-06 | 0.75 | PLOD3 COL13A1 COL4A2 COL9A2 COL9A3 COLGALT2 | extracellular structure organization |
| GO:0045229 | 3.58618738977e-06 | 0.75 | PLOD3 COL13A1 COL4A2 COL9A2 COL9A3 COLGALT2 | external encapsulating structure organization |
| REAC:R-HSA-216083 | 4.60867685367e-06 | 0.5 | COL4A2 COL9A3 COL13A1 COL9A2 | Integrin cell surface interactions |
| GO:0005581 | 1.62421193037e-05 | 0.5 | COL4A2 COL9A3 COL13A1 COL9A2 | collagen trimer |
| REAC:R-HSA-1474228 | 3.66448026627e-05 | 0.5 | COL4A2 COL9A3 COL13A1 COL9A2 | Degradation of the extracellular matrix |
| GO:0030020 | 4.35075554541e-05 | 0.5 | COL4A2 COL9A3 COL13A1 COL9A2 | extracellular matrix structural constituent conferring tensile strength |
| REAC:R-HSA-419037 | 6.65860913492e-05 | 0.375 | COL4A2 COL9A2 COL9A3 | NCAM1 interactions |
| HPA:0200273 | 8.97673402795e-05 | 0.25 | COL9A3 COL9A2 | eye; hyaloid membrane[High] |
| HPA:0200271 | 0.000179485535893 | 0.25 | COL9A3 COL9A2 | eye; hyaloid membrane[>=Low] |
| HPA:0200272 | 0.000179485535893 | 0.25 | COL9A3 COL9A2 | eye; hyaloid membrane[>=Medium] |
| HPA:0070113 | 0.000179485535893 | 0.25 | COL9A3 COL9A2 | cartilage; chondrocytes[High] |
| KEGG:04512 | 0.000251141708404 | 0.375 | COL4A2 COL9A2 COL9A3 | ECM-receptor interaction |
| REAC:R-HSA-375165 | 0.000260330782854 | 0.375 | COL4A2 COL9A2 COL9A3 | NCAM signaling for neurite out-growth |
| WP:WP4789 | 0.000358447219737 | 0.25 | COL9A3 COL9A2 | MED and pseudoachondroplasia genes |
| REAC:R-HSA-2022090 | 0.000367233569698 | 0.375 | COL4A2 COL9A2 COL9A3 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-186797 | 0.000391615111842 | 0.375 | COL4A2 COL9A2 COL9A3 | Signaling by PDGF |
| HPA:0070112 | 0.000627683621469 | 0.25 | COL9A3 COL9A2 | cartilage; chondrocytes[>=Medium] |
| HPA:0070111 | 0.000627683621469 | 0.25 | COL9A3 COL9A2 | cartilage; chondrocytes[>=Low] |
| HPA:0070000 | 0.000627683621469 | 0.25 | COL9A3 COL9A2 | cartilage |
| HP:0012770 | 0.000677898190386 | 0.25 | COL9A3 COL9A2 | Reduced arm span |
| HP:0009189 | 0.000677898190386 | 0.25 | COL9A3 COL9A2 | Fragmentation of the metacarpal epiphyses |
| HP:0006190 | 0.000677898190386 | 0.25 | COL9A3 COL9A2 | Radially deviated wrists |
| HP:0003946 | 0.000677898190386 | 0.25 | COL9A3 COL9A2 | Abnormality of the epiphyses of the elbow |
| HP:0003841 | 0.000677898190386 | 0.25 | COL9A3 COL9A2 | Fragmented epiphyses of the upper limbs |
| REAC:R-HSA-3000178 | 0.000696845667831 | 0.375 | COL4A2 COL9A2 COL9A3 | ECM proteoglycans |
| HP:0006055 | 0.00135542525381 | 0.25 | COL9A3 COL9A2 | Ulnar deviated club hands |
| HP:0100168 | 0.00225842370351 | 0.25 | COL9A3 COL9A2 | Fragmented epiphyses |
| HP:0003999 | 0.00225842370351 | 0.25 | COL9A3 COL9A2 | Abnormality of radial epiphyses |
| HP:0010631 | 0.00338670821406 | 0.25 | COL9A3 COL9A2 | Abnormality of the epiphyses of the feet |
| GO:0005788 | 0.00355755965791 | 0.625 | COLGALT2 COL9A3 COL13A1 COL4A2 COL9A2 | endoplasmic reticulum lumen |
| KEGG:04510 | 0.00432603102979 | 0.375 | COL4A2 COL9A2 COL9A3 | Focal adhesion |
| HP:0006500 | 0.00615179618571 | 0.375 | PLOD3 COL9A2 COL9A3 | Abnormal lower limb epiphysis morphology |
| HPA:0200000 | 0.00625282014335 | 0.25 | COL9A3 COL9A2 | eye |
| HP:0012769 | 0.0063183945919 | 0.25 | COL9A3 COL9A2 | Abnormal arm span |
| HP:0003365 | 0.0063183945919 | 0.25 | COL9A3 COL9A2 | Arthralgia of the hip |
| HP:0009486 | 0.00812142628406 | 0.25 | COL9A3 COL9A2 | Radial deviation of the hand |
| KEGG:00514 | 0.0100194502952 | 0.25 | PLOD3 COLGALT2 | Other types of O-glycan biosynthesis |
| GO:0005201 | 0.0119973146137 | 0.5 | COL4A2 COL9A3 COL13A1 COL9A2 | extracellular matrix structural constituent |
| HP:0012368 | 0.0125453921352 | 0.375 | PLOD3 COL9A2 COL9A3 | Flat face |
| REAC:R-HSA-422475 | 0.0156587020597 | 0.5 | COL4A2 COL9A3 DOK1 COL9A2 | Axon guidance |
| HP:0000926 | 0.0174360327694 | 0.375 | PLOD3 COL9A2 COL9A3 | Platyspondyly |
| HP:0030973 | 0.0175771621337 | 0.25 | COL9A3 COL9A2 | Postexertional symptom exacerbation |
| HP:0030839 | 0.0175771621337 | 0.25 | COL9A3 COL9A2 | Knee pain |
| HP:0010665 | 0.0175771621337 | 0.25 | COL9A3 COL9A2 | Bilateral coxa valga |
| HP:0002515 | 0.0179343735586 | 0.375 | COL9A3 COL13A1 COL9A2 | Waddling gait |
| REAC:R-HSA-9675108 | 0.0180671751641 | 0.5 | COL4A2 COL9A3 DOK1 COL9A2 | Nervous system development |
| HP:0006505 | 0.0184420315351 | 0.375 | PLOD3 COL9A2 COL9A3 | Abnormal limb epiphysis morphology |
| KEGG:04151 | 0.0191136955138 | 0.375 | COL4A2 COL9A2 COL9A3 | PI3K-Akt signaling pathway |
| KEGG:05165 | 0.0207258251199 | 0.375 | COL4A2 COL9A2 COL9A3 | Human papillomavirus infection |
| KEGG:00310 | 0.0211290680368 | 0.25 | PLOD3 COLGALT2 | Lysine degradation |
| HP:0100694 | 0.0270195830756 | 0.25 | COL9A3 COL9A2 | Tibial torsion |
| HP:0003546 | 0.0285778201567 | 0.375 | COL9A3 COL13A1 COL9A2 | Exercise intolerance |
| WP:WP4172 | 0.0300698308207 | 0.375 | COL4A2 COL9A2 COL9A3 | PI3K Akt signaling pathway |
| HP:0005913 | 0.0306138099712 | 0.25 | COL9A3 COL9A2 | Abnormal metacarpal epiphysis morphology |
| HP:0007773 | 0.0344311064357 | 0.25 | COL9A3 COL9A2 | Vitreoretinopathy |
| HP:0003502 | 0.0344311064357 | 0.25 | COL9A3 COL9A2 | Mild short stature |
| HP:0010585 | 0.0344311064357 | 0.25 | COL9A3 COL9A2 | Small epiphyses |
| HP:0010582 | 0.0384712883781 | 0.25 | COL9A3 COL9A2 | Irregular epiphyses |
| GO:0005594 | 0.0393180950424 | 0.25 | COL9A3 COL9A2 | collagen type IX trimer |
| GO:0050211 | 0.0393180950424 | 0.25 | PLOD3 COLGALT2 | procollagen galactosyltransferase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| COLGALT2 | PLOD3 | 0.998 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| COL13A1 | COLGALT2 | 0.994 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COLGALT2 | COL9A3 | 0.988 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COLGALT2 | ODF2 | 0.986 | 0.194 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| COLGALT2 | COL9A2 | 0.984 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COL9A2 | PLOD3 | 0.982 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COL4A2 | COLGALT2 | 0.979 | 0.114 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| COL9A3 | PLOD3 | 0.978 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COL13A1 | PLOD3 | 0.971 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COLGALT2 | DOK1 | 0.959 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| COL4A2 | PLOD3 | 0.955 | 0.174 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only | |
| COL13A1 | ODF2 | 0.768 | bioplex_WMM bioplex3_WMM WMM_only | ||
| COL9A2 | ODF2 | 0.768 | bioplex3_WMM WMM_only | ||
| COL9A3 | ODF2 | 0.656 | bioplex3_WMM WMM_only | ||
| COL9A2 | COL9A3 | 0.616 | bioplex3_WMM WMM_only | ||
| COL13A1 | COL9A2 | 0.616 | bioplex3_WMM WMM_only | ||
| ODF2 | PLOD3 | 0.462 | 0.136 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| COL13A1 | COL9A3 | 0.455 | bioplex3_WMM WMM_only | ||
| COL4A2 | COL13A1 | 0.326 | bioplex_WMM bioplex3_WMM WMM_only | ||
| COL4A2 | ODF2 | 0.235 | 0.1 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| COL4A2 | DOK1 | 0.22 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only | |
| DOK1 | COL9A2 | 0.214 | bioplex3_WMM WMM_only | ||
| DOK1 | COL9A3 | 0.214 | bioplex3_WMM WMM_only | ||
| COL13A1 | DOK1 | 0.146 | bioplex3_WMM WMM_only | ||
| DOK1 | PLOD3 | 0.075 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only | |
| COL4A2 | COL9A3 | 0.072 | bioplex3_WMM WMM_only | ||
| DOK1 | ODF2 | 0.055 | 0.196 | bioplex3_WMM WMM_only | |
| COL4A2 | COL9A2 | 0.046 | bioplex3_WMM WMM_only |
Related Complexes