hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05936.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KAT8 | Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF) | 5 | UniProt NCBI |
| MSL3 | Male-specific lethal 3 homolog (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) | 5 | UniProt NCBI |
| MSL1 | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | 5 | UniProt NCBI |
| MSL2 | E3 ubiquitin-protein ligase MSL2 (EC 2.3.2.-) (E3 ubiquitin-protein transferase MSL2) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7220 | 4.80157500167e-14 | 1.0 | KAT8 MSL2 MSL3 MSL1 | MSL complex |
| GO:0072487 | 1.31563155046e-10 | 1.0 | KAT8 MSL2 MSL3 MSL1 | MSL complex |
| CORUM:610 | 2.80628050973e-09 | 0.75 | KAT8 MSL3 MSL2 | MSL complex |
| REAC:R-HSA-3214847 | 1.05724689171e-06 | 1.0 | KAT8 MSL2 MSL3 MSL1 | HATs acetylate histones |
| GO:1902562 | 2.94517278885e-06 | 1.0 | KAT8 MSL2 MSL3 MSL1 | H4 histone acetyltransferase complex |
| REAC:R-HSA-3247509 | 1.52577488119e-05 | 1.0 | KAT8 MSL2 MSL3 MSL1 | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 1.52577488119e-05 | 1.0 | KAT8 MSL2 MSL3 MSL1 | Chromatin organization |
| GO:0000123 | 6.13581611239e-05 | 1.0 | KAT8 MSL2 MSL3 MSL1 | histone acetyltransferase complex |
| GO:0031248 | 9.50485907417e-05 | 1.0 | KAT8 MSL2 MSL3 MSL1 | protein acetyltransferase complex |
| GO:1902493 | 9.50485907417e-05 | 1.0 | KAT8 MSL2 MSL3 MSL1 | acetyltransferase complex |
| GO:0046972 | 0.0280843539964 | 0.5 | KAT8 MSL3 | histone H4K16 acetyltransferase activity |
| CORUM:724 | 0.049938562206 | 0.25 | KAT8 | MAF2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MSL2 | KAT8 | 0.999 | 0.146 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| MSL1 | KAT8 | 0.999 | 0.39 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| MSL2 | MSL3 | 0.998 | 0.216 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MSL1 | MSL2 | 0.996 | 0.32 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MSL1 | MSL3 | 0.99 | 0.242 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KAT8 | MSL3 | 0.855 | 0.17 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
Related Complexes