hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05942.1
Complex Portal: CPX-23164
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ALDH1B1 | Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1) | 5 | UniProt NCBI |
| ALDH2 | Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00340 | 1.70698179197e-05 | 1.0 | ALDH2 ALDH1B1 | Histidine metabolism |
| KEGG:00770 | 2.21094784484e-05 | 1.0 | ALDH2 ALDH1B1 | Pantothenate and CoA biosynthesis |
| KEGG:00053 | 3.75535994234e-05 | 1.0 | ALDH2 ALDH1B1 | Ascorbate and aldarate metabolism |
| KEGG:00410 | 5.70619627602e-05 | 1.0 | ALDH2 ALDH1B1 | beta-Alanine metabolism |
| KEGG:00380 | 8.58367986819e-05 | 1.0 | ALDH2 ALDH1B1 | Tryptophan metabolism |
| REAC:R-HSA-71384 | 9.39818963671e-05 | 1.0 | ALDH2 ALDH1B1 | Ethanol oxidation |
| KEGG:00071 | 0.000126804361689 | 1.0 | ALDH2 ALDH1B1 | Fatty acid degradation |
| KEGG:00620 | 0.000146800434109 | 1.0 | ALDH2 ALDH1B1 | Pyruvate metabolism |
| KEGG:00330 | 0.000146800434109 | 1.0 | ALDH2 ALDH1B1 | Arginine and proline metabolism |
| KEGG:00280 | 0.00016825963378 | 1.0 | ALDH2 ALDH1B1 | Valine, leucine and isoleucine degradation |
| KEGG:00561 | 0.000224021038984 | 1.0 | ALDH2 ALDH1B1 | Glycerolipid metabolism |
| KEGG:00310 | 0.000268727704965 | 1.0 | ALDH2 ALDH1B1 | Lysine degradation |
| KEGG:00010 | 0.000307419292249 | 1.0 | ALDH2 ALDH1B1 | Glycolysis / Gluconeogenesis |
| KEGG:04936 | 0.00123975649005 | 1.0 | ALDH2 ALDH1B1 | Alcoholic liver disease |
| KEGG:01240 | 0.00144865854745 | 1.0 | ALDH2 ALDH1B1 | Biosynthesis of cofactors |
| REAC:R-HSA-211945 | 0.00499983688673 | 1.0 | ALDH2 ALDH1B1 | Phase I - Functionalization of compounds |
| REAC:R-HSA-211859 | 0.0225607814134 | 1.0 | ALDH2 ALDH1B1 | Biological oxidations |
| WP:WP4966 | 0.0373151717536 | 0.5 | ALDH2 | Fluoroacetic acid toxicity |
| GO:0004029 | 0.0426062655276 | 1.0 | ALDH2 ALDH1B1 | aldehyde dehydrogenase (NAD+) activity |
| GO:0004030 | 0.0491610756088 | 1.0 | ALDH2 ALDH1B1 | aldehyde dehydrogenase [NAD(P)+] activity |
| REAC:R-HSA-380612 | 0.0499419797295 | 0.5 | ALDH2 | Metabolism of serotonin |
| REAC:R-HSA-380615 | 0.0499419797295 | 0.5 | ALDH2 | Serotonin clearance from the synaptic cleft |
| HP:0001033 | 0.0499436884913 | 0.5 | ALDH2 | Facial flushing after alcohol intake |
| HP:0003533 | 0.0499436884913 | 0.5 | ALDH2 | Reduced acetaldehyde dehydrogenase level |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ALDH2 | ALDH1B1 | 0.993 | 0.268 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM treiber_WMM |
Related Complexes