List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_05947.1

Confidence: Very High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
E2F5	Transcription factor E2F5 (E2F-5)	5	UniProt   NCBI
RBL2	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)	5	UniProt   NCBI
TFDP2	Transcription factor Dp-2 (E2F dimerization partner 2)	5	UniProt   NCBI
E2F1	Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)	5	UniProt   NCBI
E2F2	Transcription factor E2F2 (E2F-2)	5	UniProt   NCBI
MCIDAS	Multicilin (Multiciliate differentiation and DNA synthesis-associated cell cycle protein) (McIdas protein) (Protein Idas)	5	UniProt   NCBI
RBL1	Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)	5	UniProt   NCBI
E2F3	Transcription factor E2F3 (E2F-3)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-69236	3.22101990612e-15	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	G1 Phase
REAC:R-HSA-69231	3.22101990612e-15	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	Cyclin D associated events in G1
WP:WP179	1.19822903986e-12	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	Cell cycle
KEGG:04110	4.29104596965e-12	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	Cell cycle
REAC:R-HSA-1362300	6.43259852157e-12	0.625	E2F5 RBL1 E2F1 RBL2 TFDP2	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
REAC:R-HSA-453279	1.52268974335e-11	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	Mitotic G1 phase and G1/S transition
REAC:R-HSA-1362277	1.83437227329e-11	0.625	E2F5 RBL1 E2F1 RBL2 TFDP2	Transcription of E2F targets under negative control by DREAM complex
REAC:R-HSA-1538133	1.40639331372e-10	0.625	E2F5 RBL1 E2F1 RBL2 TFDP2	G0 and Early G1
REAC:R-HSA-69205	1.72573247338e-10	0.625	E2F5 RBL1 E2F1 RBL2 TFDP2	G1/S-Specific Transcription
KEGG:04218	9.46714786169e-10	0.75	E2F1 RBL1 E2F2 E2F3 E2F5 RBL2	Cellular senescence
REAC:R-HSA-9659787	1.86009193219e-08	0.5	TFDP2 E2F3 E2F2 E2F1	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
REAC:R-HSA-9661069	1.86009193219e-08	0.5	TFDP2 E2F3 E2F2 E2F1	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
REAC:R-HSA-69278	1.24107692715e-07	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	Cell Cycle, Mitotic
REAC:R-HSA-2559585	3.18690821415e-07	0.5	TFDP2 E2F3 E2F2 E2F1	Oncogene Induced Senescence
REAC:R-HSA-9687139	4.07608325548e-07	0.5	TFDP2 E2F3 E2F2 E2F1	Aberrant regulation of mitotic cell cycle due to RB1 defects
REAC:R-HSA-9675126	5.13916796434e-07	0.5	TFDP2 E2F3 E2F2 E2F1	Diseases of mitotic cell cycle
REAC:R-HSA-1640170	5.28730863704e-07	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	Cell Cycle
REAC:R-HSA-69206	6.01158968587e-07	0.625	E2F5 RBL1 E2F1 RBL2 TFDP2	G1/S Transition
WP:WP5180	1.05136071493e-06	0.5	E2F5 RBL1 RBL2 TFDP2	DYRK1A involvement regarding cell proliferation in brain development
REAC:R-HSA-6791312	1.15734333971e-06	0.5	TFDP2 RBL1 RBL2 E2F1	TP53 Regulates Transcription of Cell Cycle Genes
GO:0005667	1.99498512604e-06	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	transcription regulator complex
WP:WP45	2.107642217e-06	0.5	TFDP2 E2F3 E2F2 E2F1	G1 to S cell cycle control
WP:WP2446	7.01018894981e-06	0.5	TFDP2 E2F3 E2F2 E2F1	Retinoblastoma gene in cancer
REAC:R-HSA-69202	1.34761418673e-05	0.5	E2F5 E2F1 RBL2 TFDP2	Cyclin E associated events during G1/S transition
REAC:R-HSA-69656	1.48598663575e-05	0.5	E2F5 E2F1 RBL2 TFDP2	Cyclin A:Cdk2-associated events at S phase entry
REAC:R-HSA-6804114	1.55196545534e-05	0.375	TFDP2 RBL2 RBL1	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
KEGG:05219	3.77309774533e-05	0.375	E2F1 E2F2 E2F3	Bladder cancer
REAC:R-HSA-2559580	3.95433493773e-05	0.5	TFDP2 E2F3 E2F2 E2F1	Oxidative Stress Induced Senescence
CORUM:5144	7.17483486175e-05	0.25	E2F1 RBL1	E2F1-p107-cyclinA complex
CORUM:1473	7.17483486175e-05	0.25	E2F5 RBL2	E2F5-RB2-DP1 complex
REAC:R-HSA-2173796	0.000162162924374	0.375	E2F5 RBL1 TFDP2	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REAC:R-HSA-69242	0.000194205912298	0.5	E2F5 E2F1 RBL2 TFDP2	S Phase
KEGG:05218	0.000198526350575	0.375	E2F1 E2F2 E2F3	Melanoma
CORUM:1471	0.000239030245992	0.25	E2F5 RBL2	pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300)
CORUM:2975	0.000239030245992	0.25	E2F5 RBL1	SMAD3-E2F4/5-p107-DP1 complex
CORUM:5117	0.000239030245992	0.25	E2F5 RBL2	RBL2 complex (DNMT1, E2F4, E2F5, HDAC1, SUV39H1, RBL2)
KEGG:05214	0.000262665274355	0.375	E2F1 E2F2 E2F3	Glioma
KEGG:05223	0.000262665274355	0.375	E2F1 E2F2 E2F3	Non-small cell lung cancer
REAC:R-HSA-2559583	0.00028497836115	0.5	TFDP2 E2F3 E2F2 E2F1	Cellular Senescence
KEGG:05212	0.000312260387677	0.375	E2F1 E2F2 E2F3	Pancreatic cancer
WP:WP4685	0.000331238553774	0.375	E2F1 E2F2 E2F3	Melanoma
KEGG:05220	0.000339227897214	0.375	E2F1 E2F2 E2F3	Chronic myeloid leukemia
CORUM:1474	0.000358447219737	0.25	E2F5 RBL1	SMAD3/4-E2F4/5-p107-DP1 complex
CORUM:5118	0.000358447219737	0.25	E2F5 RBL2	RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2)
CORUM:6444	0.000358447219737	0.25	RBL2 RBL1	SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex
REAC:R-HSA-2173793	0.000443554013344	0.375	E2F5 RBL1 TFDP2	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
KEGG:01522	0.000462486513354	0.375	E2F1 E2F2 E2F3	Endocrine resistance
WP:WP4255	0.00046287066695	0.375	E2F1 E2F2 E2F3	Non small cell lung cancer
KEGG:05222	0.000533899657075	0.375	E2F1 E2F2 E2F3	Small cell lung cancer
REAC:R-HSA-111448	0.000557398190654	0.25	TFDP2 E2F1	Activation of NOXA and translocation to mitochondria
REAC:R-HSA-68911	0.000557398190654	0.25	E2F1 E2F3	G2 Phase
KEGG:05215	0.000612252918956	0.375	E2F1 E2F2 E2F3	Prostate cancer
WP:WP4263	0.000821419342632	0.375	E2F1 E2F2 E2F3	Pancreatic adenocarcinoma pathway
WP:WP4658	0.00109108919451	0.375	E2F1 E2F2 E2F3	Small cell lung cancer
GO:0000977	0.00123422340003	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0090575	0.00139940799074	0.625	E2F5 E2F3 E2F1 E2F2 TFDP2	RNA polymerase II transcription regulator complex
WP:WP53	0.00157457895347	0.25	RBL2 RBL1	ID signaling pathway
REAC:R-HSA-1912408	0.00158030541683	0.375	TFDP2 E2F3 E2F1	Pre-NOTCH Transcription and Translation
KEGG:04934	0.00164110254365	0.375	E2F1 E2F2 E2F3	Cushing syndrome
KEGG:05224	0.00172091419679	0.375	E2F1 E2F2 E2F3	Breast cancer
KEGG:05160	0.00188812744317	0.375	E2F1 E2F2 E2F3	Hepatitis C
KEGG:05226	0.00188812744317	0.375	E2F1 E2F2 E2F3	Gastric cancer
WP:WP236	0.00189816362482	0.375	E2F1 RBL2 RBL1	Adipogenesis
REAC:R-HSA-139915	0.00200443712543	0.25	TFDP2 E2F1	Activation of PUMA and translocation to mitochondria
GO:0000785	0.00212566298582	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	chromatin
GO:0000976	0.0022345160433	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	transcription cis-regulatory region binding
GO:0001067	0.0022504485569	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	transcription regulatory region nucleic acid binding
REAC:R-HSA-170834	0.00237597190289	0.375	E2F5 RBL1 TFDP2	Signaling by TGF-beta Receptor Complex
WP:WP366	0.00261051604069	0.375	E2F5 RBL2 RBL1	TGF beta signaling pathway
KEGG:05161	0.00271802931306	0.375	E2F1 E2F2 E2F3	Hepatitis B
KEGG:05206	0.00271802931306	0.375	E2F1 E2F2 E2F3	MicroRNAs in cancer
REAC:R-HSA-1912422	0.00281136504087	0.375	TFDP2 E2F3 E2F1	Pre-NOTCH Expression and Processing
GO:1990837	0.00309645370336	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	sequence-specific double-stranded DNA binding
GO:0032993	0.00320293753229	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	protein-DNA complex
KEGG:05225	0.00336544876328	0.375	E2F1 E2F2 E2F3	Hepatocellular carcinoma
GO:0001216	0.00363013100998	0.625	E2F5 E2F3 E2F1 E2F2 TFDP2	DNA-binding transcription activator activity
WP:WP4262	0.00364116708552	0.375	E2F1 E2F2 E2F3	Breast cancer pathway
REAC:R-HSA-3700989	0.00388943076684	0.5	TFDP2 RBL1 RBL2 E2F1	Transcriptional Regulation by TP53
KEGG:05167	0.00396473051169	0.375	E2F1 E2F2 E2F3	Kaposi sarcoma-associated herpesvirus infection
CORUM:5614	0.00407177869695	0.25	RBL2 RBL1	Emerin complex 32
REAC:R-HSA-113501	0.00433819320746	0.25	TFDP2 E2F1	Inhibition of replication initiation of damaged DNA by RB1/E2F1
REAC:R-HSA-9006936	0.00455165033631	0.375	E2F5 RBL1 TFDP2	Signaling by TGFB family members
KEGG:05169	0.00486719923682	0.375	E2F1 E2F2 E2F3	Epstein-Barr virus infection
GO:0043565	0.00508872640915	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	sequence-specific DNA binding
GO:0003690	0.00518576601331	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	double-stranded DNA binding
KEGG:05163	0.00589487948597	0.375	E2F1 E2F2 E2F3	Human cytomegalovirus infection
KEGG:05166	0.00645803759106	0.375	E2F1 E2F2 E2F3	Human T-cell leukemia virus 1 infection
REAC:R-HSA-113510	0.0128161014463	0.25	TFDP2 E2F1	E2F mediated regulation of DNA replication
REAC:R-HSA-212436	0.0167421784996	0.625	E2F5 RBL1 E2F1 RBL2 TFDP2	Generic Transcription Pathway
KEGG:05165	0.0207258251199	0.375	E2F1 RBL2 RBL1	Human papillomavirus infection
REAC:R-HSA-114452	0.0240813966337	0.25	TFDP2 E2F1	Activation of BH3-only proteins
GO:0005694	0.0263739534621	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	chromosome
REAC:R-HSA-73857	0.0284039231402	0.625	E2F5 RBL1 E2F1 RBL2 TFDP2	RNA Polymerase II Transcription
REAC:R-HSA-157118	0.0303228740897	0.375	TFDP2 E2F3 E2F1	Signaling by NOTCH
REAC:R-HSA-8953750	0.0310226901604	0.25	TFDP2 E2F1	Transcriptional Regulation by E2F6
GO:0003677	0.0433468686155	0.875	E2F1 RBL1 TFDP2 E2F2 E2F3 E2F5 RBL2	DNA binding
KEGG:04350	0.0474398326563	0.25	E2F5 RBL1	TGF-beta signaling pathway



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Evidence ?
E2F5	TFDP2	0.998		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     boldt_WMM
TFDP2	E2F2	0.997		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
RBL2	RBL1	0.996	0.118	bioplex_WMM     bioplex3_WMM     WMM_only     boldt_WMM
TFDP2	E2F3	0.996	0.152	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
TFDP2	E2F1	0.991		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
MCIDAS	TFDP2	0.985		bioplex3_WMM     bioplex3_HCT116     boldt_WMM     WMM_only
RBL2	TFDP2	0.967	0.122	bioplex3_WMM     bioplex3_HCT116     WMM_only
RBL1	TFDP2	0.966	0.158	bioplex3_WMM     bioplex3_HCT116     WMM_only
E2F2	E2F3	0.961		bioplex_WMM     bioplex3_WMM     WMM_only
E2F5	E2F2	0.959		bioplex_WMM     bioplex3_WMM     WMM_only
E2F5	E2F3	0.924		bioplex_WMM     bioplex3_WMM     WMM_only
MCIDAS	E2F2	0.902		bioplex3_WMM     WMM_only
MCIDAS	E2F3	0.902		bioplex3_WMM     WMM_only
MCIDAS	E2F5	0.892		bioplex_WMM     bioplex3_WMM     WMM_only     boldt_WMM
RBL1	E2F2	0.703		bioplex3_WMM     WMM_only
RBL2	E2F2	0.676		bioplex3_WMM     WMM_only
E2F1	E2F3	0.582		bioplex_WMM     bioplex3_WMM     WMM_only
E2F1	E2F2	0.568		bioplex_WMM     bioplex3_WMM     WMM_only
E2F5	E2F1	0.541		bioplex_WMM     bioplex3_WMM     WMM_only
RBL1	E2F3	0.468	0.138	bioplex3_WMM     WMM_only
RBL1	MCIDAS	0.455		bioplex3_WMM     WMM_only
RBL2	E2F3	0.418	0.12	bioplex3_WMM     WMM_only
RBL2	MCIDAS	0.405		bioplex3_WMM     WMM_only
RBL2	E2F5	0.404		bioplex3_WMM     WMM_only
RBL1	E2F5	0.384		bioplex3_WMM     WMM_only
MCIDAS	E2F1	0.214		bioplex3_WMM     WMM_only
RBL1	E2F1	0.146		bioplex3_WMM     WMM_only
RBL2	E2F1	0.131		bioplex3_WMM     WMM_only





Related Complexes

Genename	Complexes
E2F5	huMAP3_03477.1 huMAP3_04355.1 huMAP3_05947.1 huMAP3_06412.1 huMAP3_06587.1 huMAP3_08377.1 huMAP3_09319.1 huMAP3_10449.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_13863.1 huMAP3_14722.1
RBL2	huMAP3_00487.1 huMAP3_03477.1 huMAP3_05947.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_12923.1 huMAP3_14722.1
TFDP2	huMAP3_04355.1 huMAP3_05947.1 huMAP3_06412.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_14051.1
E2F1	huMAP3_04355.1 huMAP3_05947.1 huMAP3_06412.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_14051.1
E2F2	huMAP3_04355.1 huMAP3_05947.1 huMAP3_06412.1 huMAP3_10910.1 huMAP3_11168.1
MCIDAS	huMAP3_02716.1 huMAP3_04355.1 huMAP3_05947.1 huMAP3_06412.1 huMAP3_10910.1 huMAP3_11168.1
RBL1	huMAP3_00487.1 huMAP3_03164.1 huMAP3_03477.1 huMAP3_05269.1 huMAP3_05947.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_12894.1 huMAP3_12923.1 huMAP3_14722.1
E2F3	huMAP3_04355.1 huMAP3_05947.1 huMAP3_10910.1 huMAP3_11168.1