hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05948.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NUP62 | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | 5 | UniProt NCBI |
| NUP214 | Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) | 5 | UniProt NCBI |
| NUP88 | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | 5 | UniProt NCBI |
| NUP98 | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | 5 | UniProt NCBI |
| NXF1 | Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03013 | 6.92452913147e-10 | 1.0 | NUP98 NUP62 NXF1 NUP88 NUP214 | Nucleocytoplasmic transport |
| REAC:R-HSA-159227 | 1.34205029003e-08 | 0.8 | NUP62 NXF1 NUP88 NUP214 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-159230 | 1.53368765668e-08 | 0.8 | NUP62 NXF1 NUP88 NUP214 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-159231 | 3.1471608967e-08 | 0.8 | NUP62 NXF1 NUP88 NUP214 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 3.50664405889e-08 | 0.8 | NUP62 NXF1 NUP88 NUP214 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| KEGG:05014 | 2.52170502175e-07 | 1.0 | NUP98 NUP62 NXF1 NUP88 NUP214 | Amyotrophic lateral sclerosis |
| GO:0006405 | 2.95357680296e-07 | 1.0 | NUP98 NUP62 NXF1 NUP88 NUP214 | RNA export from nucleus |
| WP:WP3998 | 3.0240871454e-07 | 0.8 | NUP98 NUP62 NUP88 NUP214 | Prader Willi and Angelman syndrome |
| REAC:R-HSA-159236 | 3.9023921419e-07 | 0.8 | NUP62 NXF1 NUP88 NUP214 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-72202 | 6.39162420915e-07 | 0.8 | NUP62 NXF1 NUP88 NUP214 | Transport of Mature Transcript to Cytoplasm |
| GO:0050657 | 9.57243881415e-07 | 1.0 | NUP98 NUP62 NXF1 NUP88 NUP214 | nucleic acid transport |
| GO:0050658 | 9.57243881415e-07 | 1.0 | NUP98 NUP62 NXF1 NUP88 NUP214 | RNA transport |
| GO:0017056 | 9.61435992643e-07 | 0.8 | NUP98 NUP62 NUP88 NUP214 | structural constituent of nuclear pore |
| GO:0051236 | 1.10206110363e-06 | 1.0 | NUP98 NUP62 NXF1 NUP88 NUP214 | establishment of RNA localization |
| GO:0006403 | 3.75452059469e-06 | 1.0 | NUP98 NUP62 NXF1 NUP88 NUP214 | RNA localization |
| GO:0051168 | 4.03461847074e-06 | 1.0 | NUP98 NUP62 NXF1 NUP88 NUP214 | nuclear export |
| GO:0015931 | 5.14943131359e-06 | 1.0 | NUP98 NUP62 NXF1 NUP88 NUP214 | nucleobase-containing compound transport |
| REAC:R-HSA-5619107 | 1.01974564564e-05 | 0.6 | NUP62 NUP88 NUP214 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-170822 | 1.01974564564e-05 | 0.6 | NUP62 NUP88 NUP214 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-168333 | 1.13729170368e-05 | 0.6 | NUP62 NUP88 NUP214 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-168274 | 1.13729170368e-05 | 0.6 | NUP62 NUP88 NUP214 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-168271 | 1.13729170368e-05 | 0.6 | NUP62 NUP88 NUP214 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-180910 | 1.39876172793e-05 | 0.6 | NUP62 NUP88 NUP214 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-180746 | 1.39876172793e-05 | 0.6 | NUP62 NUP88 NUP214 | Nuclear import of Rev protein |
| REAC:R-HSA-4085377 | 1.54330255969e-05 | 0.6 | NUP62 NUP88 NUP214 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-165054 | 1.54330255969e-05 | 0.6 | NUP62 NUP88 NUP214 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-3301854 | 1.69745830215e-05 | 0.6 | NUP62 NUP88 NUP214 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-177243 | 1.861537069e-05 | 0.6 | NUP62 NUP88 NUP214 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-176033 | 1.861537069e-05 | 0.6 | NUP62 NUP88 NUP214 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-3232142 | 2.03584684634e-05 | 0.6 | NUP62 NUP88 NUP214 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-168276 | 2.41639073891e-05 | 0.6 | NUP62 NUP88 NUP214 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-168325 | 3.07163147334e-05 | 0.6 | NUP62 NUP88 NUP214 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4615885 | 3.5683276241e-05 | 0.6 | NUP62 NUP88 NUP214 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 3.83555767792e-05 | 0.6 | NUP62 NUP88 NUP214 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-2980766 | 5.03751582702e-05 | 0.6 | NUP62 NUP88 NUP214 | Nuclear Envelope Breakdown |
| GO:0051169 | 5.97436292687e-05 | 1.0 | NUP98 NUP62 NXF1 NUP88 NUP214 | nuclear transport |
| GO:0006913 | 5.97436292687e-05 | 1.0 | NUP98 NUP62 NXF1 NUP88 NUP214 | nucleocytoplasmic transport |
| REAC:R-HSA-194441 | 6.46704304154e-05 | 0.6 | NUP62 NUP88 NUP214 | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 6.46704304154e-05 | 0.6 | NUP62 NUP88 NUP214 | snRNP Assembly |
| REAC:R-HSA-6784531 | 8.14372399533e-05 | 0.6 | NUP62 NUP88 NUP214 | tRNA processing in the nucleus |
| REAC:R-HSA-72203 | 9.66841881558e-05 | 0.8 | NUP62 NXF1 NUP88 NUP214 | Processing of Capped Intron-Containing Pre-mRNA |
| REAC:R-HSA-3371453 | 0.00013544954428 | 0.6 | NUP62 NUP88 NUP214 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-70171 | 0.00013544954428 | 0.6 | NUP62 NUP88 NUP214 | Glycolysis |
| REAC:R-HSA-1169408 | 0.000141884912451 | 0.6 | NUP62 NUP88 NUP214 | ISG15 antiviral mechanism |
| REAC:R-HSA-4551638 | 0.000141884912451 | 0.6 | NUP62 NUP88 NUP214 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-5619102 | 0.000169658686915 | 0.6 | NUP62 NUP88 NUP214 | SLC transporter disorders |
| REAC:R-HSA-3108214 | 0.000177125385704 | 0.6 | NUP62 NUP88 NUP214 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 0.00018480745401 | 0.6 | NUP62 NUP88 NUP214 | Antiviral mechanism by IFN-stimulated genes |
| GO:0005643 | 0.000240717336774 | 0.8 | NUP98 NUP62 NUP88 NUP214 | nuclear pore |
| REAC:R-HSA-70326 | 0.000244866764891 | 0.6 | NUP62 NUP88 NUP214 | Glucose metabolism |
| REAC:R-HSA-3371556 | 0.000305650569508 | 0.6 | NUP62 NUP88 NUP214 | Cellular response to heat stress |
| REAC:R-HSA-5578749 | 0.000375711265178 | 0.6 | NUP62 NUP88 NUP214 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-9610379 | 0.000484679960429 | 0.6 | NUP62 NUP88 NUP214 | HCMV Late Events |
| REAC:R-HSA-72306 | 0.000484679960429 | 0.6 | NUP62 NUP88 NUP214 | tRNA processing |
| GO:0006606 | 0.000601631697955 | 0.8 | NUP98 NUP62 NUP88 NUP214 | protein import into nucleus |
| REAC:R-HSA-9705671 | 0.000703352922832 | 0.6 | NUP62 NUP88 NUP214 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| GO:0051170 | 0.000727710984203 | 0.8 | NUP98 NUP62 NUP88 NUP214 | import into nucleus |
| REAC:R-HSA-211000 | 0.000823183245594 | 0.6 | NUP62 NUP88 NUP214 | Gene Silencing by RNA |
| REAC:R-HSA-9609690 | 0.000865946803096 | 0.6 | NUP62 NUP88 NUP214 | HCMV Early Events |
| REAC:R-HSA-68875 | 0.000910160054501 | 0.6 | NUP62 NUP88 NUP214 | Mitotic Prophase |
| REAC:R-HSA-162909 | 0.000979250057704 | 0.6 | NUP62 NUP88 NUP214 | Host Interactions of HIV factors |
| REAC:R-HSA-162599 | 0.00110198471879 | 0.6 | NUP62 NUP88 NUP214 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168273 | 0.00112769600133 | 0.6 | NUP62 NUP88 NUP214 | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-5619115 | 0.00140702215103 | 0.6 | NUP62 NUP88 NUP214 | Disorders of transmembrane transporters |
| REAC:R-HSA-9609646 | 0.00143724099843 | 0.6 | NUP62 NUP88 NUP214 | HCMV Infection |
| REAC:R-HSA-162587 | 0.00143724099843 | 0.6 | NUP62 NUP88 NUP214 | HIV Life Cycle |
| REAC:R-HSA-168255 | 0.00162763371047 | 0.6 | NUP62 NUP88 NUP214 | Influenza Infection |
| REAC:R-HSA-3108232 | 0.0019808748776 | 0.6 | NUP62 NUP88 NUP214 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.00217510180244 | 0.6 | NUP62 NUP88 NUP214 | SUMOylation |
| REAC:R-HSA-913531 | 0.00269181495124 | 0.6 | NUP62 NUP88 NUP214 | Interferon Signaling |
| REAC:R-HSA-9705683 | 0.00333687251766 | 0.6 | NUP62 NUP88 NUP214 | SARS-CoV-2-host interactions |
| REAC:R-HSA-8953854 | 0.00371793814615 | 0.8 | NUP62 NXF1 NUP88 NUP214 | Metabolism of RNA |
| REAC:R-HSA-162906 | 0.00541502775671 | 0.6 | NUP62 NUP88 NUP214 | HIV Infection |
| REAC:R-HSA-71387 | 0.00840189510813 | 0.6 | NUP62 NUP88 NUP214 | Metabolism of carbohydrates |
| REAC:R-HSA-9694516 | 0.0101788028745 | 0.6 | NUP62 NUP88 NUP214 | SARS-CoV-2 Infection |
| GO:0034504 | 0.0128032452518 | 0.8 | NUP98 NUP62 NUP88 NUP214 | protein localization to nucleus |
| REAC:R-HSA-9679506 | 0.0263889851162 | 0.6 | NUP62 NUP88 NUP214 | SARS-CoV Infections |
| REAC:R-HSA-68886 | 0.0287469323532 | 0.6 | NUP62 NUP88 NUP214 | M Phase |
| GO:0006406 | 0.0437005530348 | 0.6 | NUP214 NUP88 NXF1 | mRNA export from nucleus |
| KEGG:05164 | 0.0458988724567 | 0.4 | NXF1 NUP98 | Influenza A |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NUP62 | NUP88 | 1.0 | 0.738 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| NUP214 | NUP62 | 1.0 | 0.852 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| NUP214 | NUP88 | 1.0 | 0.936 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| NUP98 | NUP88 | 0.998 | 0.964 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| NUP62 | NUP98 | 0.998 | 0.828 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| NXF1 | NUP62 | 0.992 | 0.558 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NXF1 | NUP98 | 0.992 | 0.604 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| NUP214 | NUP98 | 0.991 | 0.7 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction boldt_WMM |
| NXF1 | NUP88 | 0.984 | 0.622 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NUP214 | NXF1 | 0.977 | 0.764 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
Related Complexes