hu.MAP 3.0: Complex View

Human Protein Complex Map

Genename	Protein Name	Uniprot Annotation Score	Links
LIG1	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1)	5	UniProt NCBI
NSDHL	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (Protein H105e3)	5	UniProt NCBI
MADD	MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP)	5	UniProt NCBI
SYT3	Synaptotagmin-3 (Synaptotagmin III) (SytIII)	5	UniProt NCBI
TMPRSS11E	Transmembrane protease serine 11E (EC 3.4.21.-) (Serine protease DESC1) (Transmembrane protease serine 11E2) [Cleaved into: Transmembrane protease serine 11E non-catalytic chain; Transmembrane protease serine 11E catalytic chain]	5	UniProt NCBI
SYT6	Synaptotagmin-6 (Synaptotagmin VI) (SytVI)	5	UniProt NCBI
MPC2	Mitochondrial pyruvate carrier 2 (Brain protein 44)	5	UniProt NCBI
SYT10	Synaptotagmin-10 (Synaptotagmin X) (SytX)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0014059	0.0032492156641	0.428571428571	SYT3 SYT10 SYT6	regulation of dopamine secretion
GO:0014046	0.00516068999797	0.428571428571	SYT3 SYT10 SYT6	dopamine secretion
GO:0017158	0.00516068999797	0.428571428571	SYT3 SYT10 SYT6	regulation of calcium ion-dependent exocytosis
GO:0050433	0.00593357407009	0.428571428571	SYT3 SYT10 SYT6	regulation of catecholamine secretion
GO:0050432	0.00870569405676	0.428571428571	SYT3 SYT10 SYT6	catecholamine secretion
GO:0015872	0.0109646664486	0.428571428571	SYT3 SYT10 SYT6	dopamine transport
GO:0051937	0.0182422971773	0.428571428571	SYT3 SYT10 SYT6	catecholamine transport
GO:0017156	0.0218744047191	0.428571428571	SYT3 SYT10 SYT6	calcium-ion regulated exocytosis
GO:0015844	0.0281770340738	0.428571428571	SYT3 SYT10 SYT6	monoamine transport
GO:0051952	0.0305188440994	0.428571428571	SYT3 SYT10 SYT6	regulation of amine transport
GO:0030276	0.0383127531327	0.428571428571	SYT3 SYT10 SYT6	clathrin binding
GO:0001786	0.0441816577212	0.428571428571	SYT3 SYT10 SYT6	phosphatidylserine binding

Protein 1	Protein 2	Score	ProteomeHD	Evidence
SYT3	SYT10	0.999		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
SYT3	SYT6	0.999		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
SYT6	SYT10	0.999		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
MADD	SYT3	0.997		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
SYT6	MPC2	0.994		bioplex3_WMM bioplex3_HCT116 WMM_only
LIG1	SYT6	0.991		bioplex3_WMM bioplex3_HCT116 WMM_only
TMPRSS11E	SYT6	0.987		bioplex3_HEK293 bioplex3_WMM WMM_only
NSDHL	SYT6	0.977		bioplex3_WMM bioplex3_HCT116 WMM_only
MADD	SYT6	0.955		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
MADD	SYT10	0.675		bioplex_WMM bioplex3_WMM WMM_only
MPC2	SYT10	0.675		bioplex3_WMM WMM_only
SYT3	MPC2	0.663		bioplex3_WMM WMM_only
LIG1	MPC2	0.545	0.046	bioplex3_WMM WMM_only
LIG1	SYT10	0.478		bioplex3_WMM WMM_only
LIG1	SYT3	0.427		bioplex3_WMM WMM_only
NSDHL	SYT10	0.356		bioplex3_WMM WMM_only
NSDHL	SYT3	0.356		bioplex3_WMM WMM_only
NSDHL	MPC2	0.274	0.076	bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
LIG1	NSDHL	0.188	0.08	bioplex3_WMM youn_WMM WMM_only
MADD	MPC2	0.043	0.044	bioplex_WMM bioplex3_WMM WMM_only
MADD	LIG1	0.026	0.038	bioplex3_WMM WMM_only
MADD	NSDHL	0.024	0.024	bioplex_WMM bioplex3_WMM WMM_only

Genename	Complexes
LIG1	huMAP3_00766.1 huMAP3_00962.1 huMAP3_05951.1 huMAP3_09164.1 huMAP3_11045.1 huMAP3_12449.1
NSDHL	huMAP3_00962.1 huMAP3_01245.1 huMAP3_05951.1 huMAP3_08115.1
MADD	huMAP3_00118.1 huMAP3_00962.1 huMAP3_05951.1 huMAP3_07544.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_10475.1 huMAP3_11346.1
SYT3	huMAP3_00962.1 huMAP3_05951.1 huMAP3_14299.1
TMPRSS11E	huMAP3_00387.1 huMAP3_05951.1 huMAP3_09321.1 huMAP3_10375.1 huMAP3_11196.1
SYT6	huMAP3_00962.1 huMAP3_05951.1
MPC2	huMAP3_00962.1 huMAP3_01257.1 huMAP3_05951.1 huMAP3_12197.1
SYT10	huMAP3_00962.1 huMAP3_05951.1 huMAP3_14299.1