hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05961.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PDE6D | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17) | 5 | UniProt NCBI |
| FBXO10 | F-box only protein 10 | 5 | UniProt NCBI |
| INPP5E | Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6741 | 1.02521027753e-05 | 0.666666666667 | PDE6D INPP5E | INPP5E-PDE6D-RPGR complex |
| REAC:R-HSA-5624958 | 2.04544380615e-05 | 0.666666666667 | PDE6D INPP5E | ARL13B-mediated ciliary trafficking of INPP5E |
| HP:0002335 | 0.000986522412937 | 0.666666666667 | PDE6D INPP5E | Agenesis of cerebellar vermis |
| WP:WP4656 | 0.00280600716639 | 0.666666666667 | PDE6D INPP5E | Joubert syndrome |
| WP:WP5234 | 0.00321742070882 | 0.666666666667 | PDE6D INPP5E | Bardet Biedl syndrome |
| HP:0007973 | 0.00348901893966 | 0.666666666667 | PDE6D INPP5E | Retinal dysplasia |
| REAC:R-HSA-5620920 | 0.00704293704569 | 0.666666666667 | PDE6D INPP5E | Cargo trafficking to the periciliary membrane |
| HP:0002419 | 0.00708857159683 | 0.666666666667 | PDE6D INPP5E | Molar tooth sign on MRI |
| WP:WP4803 | 0.0135986549013 | 0.666666666667 | PDE6D INPP5E | Ciliopathies |
| HP:0002876 | 0.0148492820647 | 0.666666666667 | PDE6D INPP5E | Episodic tachypnea |
| HP:0004422 | 0.0201452261528 | 0.666666666667 | PDE6D INPP5E | Biparietal narrowing |
| HP:0001830 | 0.024644630388 | 0.666666666667 | PDE6D INPP5E | Postaxial foot polydactyly |
| HP:0002418 | 0.0295957156854 | 0.666666666667 | PDE6D INPP5E | Abnormal midbrain morphology |
| HP:0010322 | 0.0408514331117 | 0.666666666667 | PDE6D INPP5E | Abnormal fifth toe morphology |
| HP:0001162 | 0.0408514331117 | 0.666666666667 | PDE6D INPP5E | Postaxial hand polydactyly |
| HP:0002789 | 0.0429026841472 | 0.666666666667 | PDE6D INPP5E | Tachypnea |
| CORUM:6740 | 0.0499402709677 | 0.333333333333 | INPP5E | AURKA-INPP5E complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PDE6D | INPP5E | 0.998 | bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| PDE6D | FBXO10 | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FBXO10 | INPP5E | 0.757 | bioplex3_WMM WMM_only |
Related Complexes