hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05966.1
Complex Portal: CPX-20220
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| H4C1 | Histone H4 | 5 | UniProt NCBI |
| H3C1 | Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l) | 5 | UniProt NCBI |
| H3-3A | Histone H3.3 | 5 | UniProt NCBI |
| NASP | Nuclear autoantigenic sperm protein (NASP) | 5 | UniProt NCBI |
| CHAF1A | Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) (hp150) | 5 | UniProt NCBI |
| H3-7 | Histone H3-7 | 4 | UniProt NCBI |
| ATRX | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1149 | 0.000143457417375 | 0.5 | CHAF1A NASP | Histone H3.1 complex |
| HPA:0470203 | 0.00264136105546 | 0.75 | ATRX NASP H3-7 | skin 2; endothelial cells[High] |
| HPA:0600433 | 0.00268899235574 | 1.0 | CHAF1A ATRX NASP H3-7 | tonsil; germinal center cells[High] |
| HPA:0460182 | 0.0136756650941 | 0.75 | ATRX NASP H3-7 | skin 1; cells in granular layer[>=Medium] |
| HPA:0470182 | 0.0137538378506 | 0.75 | ATRX NASP H3-7 | skin 2; cells in granular layer[>=Medium] |
| HPA:0461462 | 0.0163259099541 | 0.75 | ATRX NASP H3-7 | skin 1; langerhans cells[>=Medium] |
| HPA:0460202 | 0.0169474947772 | 0.75 | ATRX NASP H3-7 | skin 1; endothelial cells[>=Medium] |
| HPA:0461412 | 0.017037547013 | 0.75 | ATRX NASP H3-7 | skin 1; cells in spinous layer[>=Medium] |
| HPA:0470202 | 0.0206978936317 | 0.75 | ATRX NASP H3-7 | skin 2; endothelial cells[>=Medium] |
| HPA:0461392 | 0.0214240997702 | 0.75 | ATRX NASP H3-7 | skin 1; cells in basal layer[>=Medium] |
| HPA:0471472 | 0.0218465167628 | 0.75 | ATRX NASP H3-7 | skin 2; lymphocytes[>=Medium] |
| HPA:0471462 | 0.0233681465302 | 0.75 | ATRX NASP H3-7 | skin 2; langerhans cells[>=Medium] |
| HPA:0471412 | 0.025307719873 | 0.75 | ATRX NASP H3-7 | skin 2; cells in spinous layer[>=Medium] |
| HPA:0461442 | 0.0272274003475 | 0.75 | ATRX NASP H3-7 | skin 1; fibrohistiocytic cells[>=Medium] |
| HPA:0460181 | 0.0284745500846 | 0.75 | ATRX NASP H3-7 | skin 1; cells in granular layer[>=Low] |
| HPA:0470181 | 0.0287284084928 | 0.75 | ATRX NASP H3-7 | skin 2; cells in granular layer[>=Low] |
| HPA:0461461 | 0.0306799890508 | 0.75 | ATRX NASP H3-7 | skin 1; langerhans cells[>=Low] |
| GO:0006334 | 0.0326725154884 | 0.75 | CHAF1A NASP ATRX | nucleosome assembly |
| HPA:0471392 | 0.0346964580744 | 0.75 | ATRX NASP H3-7 | skin 2; cells in basal layer[>=Medium] |
| HPA:0461411 | 0.0364546459466 | 0.75 | ATRX NASP H3-7 | skin 1; cells in spinous layer[>=Low] |
| HPA:0471461 | 0.0392002139957 | 0.75 | ATRX NASP H3-7 | skin 2; langerhans cells[>=Low] |
| HPA:0471471 | 0.0414271565288 | 0.75 | ATRX NASP H3-7 | skin 2; lymphocytes[>=Low] |
| GO:0070087 | 0.042122686785 | 0.5 | CHAF1A ATRX | chromo shadow domain binding |
| GO:0006335 | 0.042122686785 | 0.5 | CHAF1A NASP | DNA replication-dependent chromatin assembly |
| HPA:0471442 | 0.0454353332194 | 0.75 | ATRX NASP H3-7 | skin 2; fibrohistiocytic cells[>=Medium] |
| HPA:0460201 | 0.0471778151727 | 0.75 | ATRX NASP H3-7 | skin 1; endothelial cells[>=Low] |
| CORUM:2839 | 0.049938562206 | 0.25 | ATRX | ATRX-DAXX complex |
| CORUM:2233 | 0.049938562206 | 0.25 | CHAF1A | Replication-coupled CAF-1-MBD1-ETDB1 complex |
| CORUM:2843 | 0.049938562206 | 0.25 | ATRX | ATRX-DAXX complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CHAF1A | H3C1 | 1.0 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| H4C1 | H3C1 | 0.999 | 0.592 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| NASP | H3C1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | ||
| H4C1 | NASP | 0.997 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM | |
| CHAF1A | H4C1 | 0.996 | 0.271650649666 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CHAF1A | ATRX | 0.994 | 0.1 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| ATRX | H4C1 | 0.993 | 0.490862888483 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| H4C1 | H3-3A | 0.988 | 0.946 |
mutually_exclusive (Q5TEC6)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM treiber_WMM WMM_only |
| H3-3A | NASP | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | ||
| ATRX | H3-3A | 0.962 | 0.37697029703 | bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only | |
| CHAF1A | NASP | 0.949 | bioplex_WMM bioplex3_WMM youn_WMM fraction | ||
| ATRX | H3C1 | 0.55 | 0.23 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| H3-3A | H3C1 | 0.171 | 0.53 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| ATRX | NASP | 0.157 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| CHAF1A | H3-3A | 0.14 | 0.312086148649 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes