hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05995.1

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
DDX39A	ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49)	5	UniProt NCBI
THOC2	THO complex subunit 2 (Tho2) (hTREX120)	5	UniProt NCBI
ZC3H11A	Zinc finger CCCH domain-containing protein 11A	5	UniProt NCBI
SPEN	Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)	5	UniProt NCBI
DDX39B	Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-72187	1.4527589399e-07	0.8	DDX39B THOC2 DDX39A ZC3H11A	mRNA 3'-end processing
REAC:R-HSA-73856	2.53618197426e-07	0.8	DDX39B THOC2 DDX39A ZC3H11A	RNA Polymerase II Transcription Termination
REAC:R-HSA-159236	3.9023921419e-07	0.8	DDX39B THOC2 DDX39A ZC3H11A	Transport of Mature mRNA derived from an Intron-Containing Transcript
REAC:R-HSA-72202	6.39162420915e-07	0.8	DDX39B THOC2 DDX39A ZC3H11A	Transport of Mature Transcript to Cytoplasm
GO:0006406	9.44983107329e-05	0.8	DDX39B THOC2 DDX39A ZC3H11A	mRNA export from nucleus
REAC:R-HSA-72203	9.66841881558e-05	0.8	DDX39B THOC2 DDX39A ZC3H11A	Processing of Capped Intron-Containing Pre-mRNA
GO:0051028	0.000134846916955	0.8	DDX39B THOC2 DDX39A ZC3H11A	mRNA transport
GO:0000346	0.000158467845213	0.6	THOC2 DDX39B ZC3H11A	transcription export complex
GO:0006405	0.000265205672168	0.8	DDX39B THOC2 DDX39A ZC3H11A	RNA export from nucleus
CORUM:770	0.000286457379015	0.4	THOC2 DDX39B	TREX complex
GO:0050657	0.000675117158035	0.8	DDX39B THOC2 DDX39A ZC3H11A	nucleic acid transport
GO:0050658	0.000675117158035	0.8	DDX39B THOC2 DDX39A ZC3H11A	RNA transport
GO:0051236	0.000755130188848	0.8	DDX39B THOC2 DDX39A ZC3H11A	establishment of RNA localization
CORUM:351	0.0011586928604	0.6	THOC2 SPEN DDX39B	Spliceosome
GO:0006403	0.00200179443266	0.8	DDX39B THOC2 DDX39A ZC3H11A	RNA localization
GO:0051168	0.00211972422452	0.8	DDX39B THOC2 DDX39A ZC3H11A	nuclear export
GO:0015931	0.00257382782381	0.8	DDX39B THOC2 DDX39A ZC3H11A	nucleobase-containing compound transport
REAC:R-HSA-8953854	0.00371793814615	0.8	DDX39B THOC2 DDX39A ZC3H11A	Metabolism of RNA
REAC:R-HSA-9706574	0.00900400267976	0.4	SPEN DDX39B	RHOBTB GTPase Cycle
HPA:0630053	0.0120291616551	0.8	DDX39B THOC2 SPEN ZC3H11A	cervix; glandular cells[High]
HPA:0380513	0.0139358135714	0.8	DDX39B THOC2 SPEN ZC3H11A	placenta; decidual cells[High]
GO:0051169	0.0180995584082	0.8	DDX39B THOC2 DDX39A ZC3H11A	nuclear transport
GO:0006913	0.0180995584082	0.8	DDX39B THOC2 DDX39A ZC3H11A	nucleocytoplasmic transport
KEGG:03013	0.0226459969921	0.4	THOC2 DDX39B	Nucleocytoplasmic transport
HPA:0301363	0.02767916363	0.6	THOC2 SPEN DDX39B	lung; alveolar cells type I[High]
REAC:R-HSA-73857	0.0284318585439	0.8	DDX39B THOC2 DDX39A ZC3H11A	RNA Polymerase II Transcription
KEGG:03040	0.0346393491085	0.4	THOC2 DDX39B	Spliceosome
HPA:0490693	0.0465736551749	0.6	THOC2 SPEN DDX39B	smooth muscle; smooth muscle cells[High]
REAC:R-HSA-74160	0.046583533294	0.8	DDX39B THOC2 DDX39A ZC3H11A	Gene expression (Transcription)

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
THOC2	DDX39B	0.999	0.458	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM
ZC3H11A	THOC2	0.998	0.486	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM
DDX39A	DDX39B	0.998	0.446	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM
ZC3H11A	DDX39A	0.996	0.184	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction
ZC3H11A	DDX39B	0.996	0.308	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM
DDX39A	THOC2	0.989	0.174	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction treiber_WMM
ZC3H11A	SPEN	0.967	0.226	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
DDX39B	SPEN	0.275	0.142	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
THOC2	SPEN	0.21	0.242	hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
DDX39A	SPEN	0.008	0.052	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only

Related Complexes

Genename	Complexes
DDX39A	huMAP3_01665.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_05995.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09225.1 huMAP3_09226.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
THOC2	huMAP3_01665.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_05696.1 huMAP3_05995.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09225.1 huMAP3_09226.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
ZC3H11A	huMAP3_01665.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_05696.1 huMAP3_05846.1 huMAP3_05995.1 huMAP3_08302.1 huMAP3_08820.1 huMAP3_09101.1 huMAP3_09156.1 huMAP3_09226.1 huMAP3_09552.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10564.1 huMAP3_10789.1
SPEN	huMAP3_02019.1 huMAP3_03970.1 huMAP3_05696.1 huMAP3_05995.1 huMAP3_07848.1 huMAP3_08302.1 huMAP3_08486.1 huMAP3_08820.1 huMAP3_09041.1 huMAP3_09156.1 huMAP3_09532.1 huMAP3_09587.1 huMAP3_09943.1 huMAP3_10021.1 huMAP3_10524.1
DDX39B	huMAP3_01665.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_05846.1 huMAP3_05995.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09225.1 huMAP3_09226.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05995.1