hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05995.1
Complex Portal: CPX-16160
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DDX39A | ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) | 5 | UniProt NCBI |
| THOC2 | THO complex subunit 2 (Tho2) (hTREX120) | 5 | UniProt NCBI |
| ZC3H11A | Zinc finger CCCH domain-containing protein 11A | 5 | UniProt NCBI |
| SPEN | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | 5 | UniProt NCBI |
| DDX39B | Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72187 | 1.4527589399e-07 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | mRNA 3'-end processing |
| REAC:R-HSA-73856 | 2.53618197426e-07 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | RNA Polymerase II Transcription Termination |
| REAC:R-HSA-159236 | 3.9023921419e-07 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-72202 | 6.39162420915e-07 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | Transport of Mature Transcript to Cytoplasm |
| GO:0006406 | 9.44983107329e-05 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | mRNA export from nucleus |
| REAC:R-HSA-72203 | 9.66841881558e-05 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0051028 | 0.000134846916955 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | mRNA transport |
| GO:0000346 | 0.000158467845213 | 0.6 | DDX39B THOC2 ZC3H11A | transcription export complex |
| GO:0006405 | 0.000265205672168 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | RNA export from nucleus |
| CORUM:770 | 0.000286457379015 | 0.4 | DDX39B THOC2 | TREX complex |
| GO:0050657 | 0.000675117158035 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | nucleic acid transport |
| GO:0050658 | 0.000675117158035 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | RNA transport |
| GO:0051236 | 0.000755130188848 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | establishment of RNA localization |
| CORUM:351 | 0.0011586928604 | 0.6 | DDX39B THOC2 SPEN | Spliceosome |
| GO:0006403 | 0.00200179443266 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | RNA localization |
| GO:0051168 | 0.00211972422452 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | nuclear export |
| GO:0015931 | 0.00257382782381 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | nucleobase-containing compound transport |
| REAC:R-HSA-8953854 | 0.00371793814615 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | Metabolism of RNA |
| REAC:R-HSA-9706574 | 0.00900400267976 | 0.4 | DDX39B SPEN | RHOBTB GTPase Cycle |
| HPA:0630053 | 0.0120291616551 | 0.8 | DDX39B SPEN THOC2 ZC3H11A | cervix; glandular cells[High] |
| HPA:0380513 | 0.0139358135714 | 0.8 | DDX39B SPEN THOC2 ZC3H11A | placenta; decidual cells[High] |
| GO:0051169 | 0.0180995584082 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | nuclear transport |
| GO:0006913 | 0.0180995584082 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | nucleocytoplasmic transport |
| KEGG:03013 | 0.0226459969921 | 0.4 | DDX39B THOC2 | Nucleocytoplasmic transport |
| HPA:0301363 | 0.02767916363 | 0.6 | DDX39B THOC2 SPEN | lung; alveolar cells type I[High] |
| REAC:R-HSA-73857 | 0.0284318585439 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | RNA Polymerase II Transcription |
| KEGG:03040 | 0.0346393491085 | 0.4 | DDX39B THOC2 | Spliceosome |
| HPA:0490693 | 0.0465736551749 | 0.6 | DDX39B THOC2 SPEN | smooth muscle; smooth muscle cells[High] |
| REAC:R-HSA-74160 | 0.046583533294 | 0.8 | DDX39B ZC3H11A DDX39A THOC2 | Gene expression (Transcription) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| THOC2 | DDX39B | 0.999 | 0.458 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| ZC3H11A | THOC2 | 0.998 | 0.486 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| DDX39A | DDX39B | 0.998 | 0.446 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| ZC3H11A | DDX39A | 0.996 | 0.184 |
mutually_exclusive (Q96J01)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| ZC3H11A | DDX39B | 0.996 | 0.308 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM | |
| DDX39A | THOC2 | 0.989 | 0.174 |
mutually_exclusive (Q96J01)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction treiber_WMM |
| ZC3H11A | SPEN | 0.967 | 0.226 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| DDX39B | SPEN | 0.275 | 0.142 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| THOC2 | SPEN | 0.21 | 0.242 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| DDX39A | SPEN | 0.008 | 0.052 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes