hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06005.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RCAN1 | Calcipressin-1 (Adapt78) (Down syndrome critical region protein 1) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1) | 5 | UniProt NCBI |
| PPP3R1 | Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) | 5 | UniProt NCBI |
| PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) | 5 | UniProt NCBI |
| GSK3A | Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1) | 5 | UniProt NCBI |
| TNS4 | Tensin-4 (C-terminal tensin-like protein) | 5 | UniProt NCBI |
| PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform) | 5 | UniProt NCBI |
| NFATC4 | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | 5 | UniProt NCBI |
| PPP3CA | Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) | 5 | UniProt NCBI |
| RCAN3 | Calcipressin-3 (Down syndrome candidate region 1-like protein 2) (Myocyte-enriched calcineurin-interacting protein 3) (MCIP3) (Regulator of calcineurin 3) | 5 | UniProt NCBI |
| RCAN2 | Calcipressin-2 (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin-interacting protein 2) (MCIP2) (Regulator of calcineurin 2) (Thyroid hormone-responsive protein ZAKI-4) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0019722 | 6.28268351258e-09 | 0.777777777778 | NFATC4 PPP3CC RCAN3 PPP3CA PPP3R1 RCAN2 RCAN1 | calcium-mediated signaling |
| GO:0008597 | 1.65724193228e-08 | 0.444444444444 | RCAN2 RCAN3 RCAN1 PPP3R1 | calcium-dependent protein serine/threonine phosphatase regulator activity |
| WP:WP3414 | 1.42712411928e-07 | 0.444444444444 | PPP3CC PPP3CA PPP3R1 NFATC4 | Initiation of transcription and translation elongation at the HIV 1 LTR |
| KEGG:04921 | 1.95589290429e-07 | 0.555555555556 | PPP3CC NFATC4 PPP3CA RCAN1 PPP3R1 | Oxytocin signaling pathway |
| GO:0033173 | 2.67554228815e-07 | 0.555555555556 | PPP3CC NFATC4 PPP3CA RCAN1 PPP3R1 | calcineurin-NFAT signaling cascade |
| GO:0097720 | 3.13612595242e-07 | 0.555555555556 | PPP3CC NFATC4 PPP3CA RCAN1 PPP3R1 | calcineurin-mediated signaling |
| KEGG:05167 | 1.16061325618e-06 | 0.555555555556 | PPP3CC NFATC4 PPP3CA RCAN1 PPP3R1 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04625 | 6.63847013525e-06 | 0.444444444444 | PPP3CC PPP3CA PPP3R1 NFATC4 | C-type lectin receptor signaling pathway |
| WP:WP428 | 2.40528165897e-05 | 0.444444444444 | PPP3CC PPP3CA PPP3R1 NFATC4 | Wnt signaling |
| CORUM:6023 | 2.73623797451e-05 | 0.222222222222 | PPP3R1 PPP3CA | Calcineurin |
| CORUM:2266 | 2.73623797451e-05 | 0.222222222222 | RCAN1 PPP3CA | PPP3CA-PPP3CA-RCAN1 complex |
| KEGG:04022 | 3.14265099225e-05 | 0.444444444444 | PPP3CC PPP3CA PPP3R1 NFATC4 | cGMP-PKG signaling pathway |
| REAC:R-HSA-180024 | 4.3395124826e-05 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | DARPP-32 events |
| KEGG:04218 | 4.95048641646e-05 | 0.444444444444 | PPP3CC PPP3CA PPP3R1 NFATC4 | Cellular senescence |
| KEGG:04310 | 6.52476976687e-05 | 0.444444444444 | PPP3CC PPP3CA PPP3R1 NFATC4 | Wnt signaling pathway |
| KEGG:04360 | 7.24873862122e-05 | 0.444444444444 | PPP3CC PPP3CA PPP3R1 NFATC4 | Axon guidance |
| GO:0070884 | 7.82064017367e-05 | 0.444444444444 | PPP3CC PPP3CA RCAN1 PPP3R1 | regulation of calcineurin-NFAT signaling cascade |
| GO:0005955 | 8.06911104389e-05 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | calcineurin complex |
| GO:1905949 | 8.06911104389e-05 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | negative regulation of calcium ion import across plasma membrane |
| CORUM:6374 | 8.20609246787e-05 | 0.222222222222 | PPP3R1 PPP3CA | Calcineurin-FKBP12 complex |
| GO:0106056 | 9.02134234826e-05 | 0.444444444444 | PPP3CC PPP3CA RCAN1 PPP3R1 | regulation of calcineurin-mediated signaling |
| KEGG:04020 | 0.000112702611079 | 0.444444444444 | PPP3CC PPP3CA PPP3R1 NFATC4 | Calcium signaling pathway |
| KEGG:04924 | 0.000139257471054 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Renin secretion |
| GO:1905665 | 0.000161332517231 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | positive regulation of calcium ion import across plasma membrane |
| KEGG:04370 | 0.000167515848143 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | VEGF signaling pathway |
| KEGG:05163 | 0.000174673170833 | 0.444444444444 | PPP3CC PPP3CA PPP3R1 NFATC4 | Human cytomegalovirus infection |
| KEGG:05170 | 0.00017832070469 | 0.444444444444 | PPP3CC PPP3CA PPP3R1 NFATC4 | Human immunodeficiency virus 1 infection |
| WP:WP1541 | 0.000192683082104 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Energy metabolism |
| KEGG:05166 | 0.000197414294846 | 0.444444444444 | PPP3CC PPP3CA PPP3R1 NFATC4 | Human T-cell leukemia virus 1 infection |
| KEGG:04720 | 0.000199338247144 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Long-term potentiation |
| KEGG:05031 | 0.000234931480144 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Amphetamine addiction |
| GO:1905664 | 0.000282244947588 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | regulation of calcium ion import across plasma membrane |
| GO:0004723 | 0.000282244947588 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | calcium-dependent protein serine/threonine phosphatase activity |
| KEGG:04662 | 0.000401022621003 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | B cell receptor signaling pathway |
| KEGG:04658 | 0.000517754441228 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Th1 and Th2 cell differentiation |
| KEGG:05235 | 0.0006550037849 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:04724 | 0.000679986209508 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Glutamatergic synapse |
| WP:WP1544 | 0.000756407268783 | 0.333333333333 | PPP3CA RCAN1 NFATC4 | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04659 | 0.000933696873544 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Th17 cell differentiation |
| GO:0090281 | 0.000966803032193 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | negative regulation of calcium ion import |
| KEGG:04922 | 0.000997456829385 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Glucagon signaling pathway |
| GO:0050848 | 0.00111503328238 | 0.444444444444 | PPP3CC PPP3CA RCAN1 PPP3R1 | regulation of calcium-mediated signaling |
| GO:0090280 | 0.00132894467527 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | positive regulation of calcium ion import |
| KEGG:04660 | 0.00139992564029 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | T cell receptor signaling pathway |
| KEGG:04114 | 0.00144106213769 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Oocyte meiosis |
| KEGG:04650 | 0.0016587265878 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Natural killer cell mediated cytotoxicity |
| KEGG:04728 | 0.0016587265878 | 0.333333333333 | PPP3CC GSK3A PPP3CA | Dopaminergic synapse |
| REAC:R-HSA-2025928 | 0.00167485737707 | 0.222222222222 | PPP3R1 PPP3CA | Calcineurin activates NFAT |
| GO:0019888 | 0.00182029811799 | 0.444444444444 | RCAN2 RCAN3 RCAN1 PPP3R1 | protein phosphatase regulator activity |
| KEGG:04380 | 0.00194722583522 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Osteoclast differentiation |
| REAC:R-HSA-111885 | 0.00284454699146 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Opioid Signalling |
| REAC:R-HSA-5607763 | 0.00286935042585 | 0.222222222222 | PPP3R1 PPP3CA | CLEC7A (Dectin-1) induces NFAT activation |
| GO:0019208 | 0.00334782846127 | 0.444444444444 | RCAN2 RCAN3 RCAN1 PPP3R1 | phosphatase regulator activity |
| KEGG:05152 | 0.00396874980186 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Tuberculosis |
| GO:0034763 | 0.00417039795891 | 0.444444444444 | PPP3CC PPP3CA PPP3R1 GSK3A | negative regulation of transmembrane transport |
| WP:WP4482 | 0.00581046009857 | 0.222222222222 | PPP3R1 PPP3CA | Vitamin D in inflammatory diseases |
| WP:WP1528 | 0.00642003616322 | 0.222222222222 | NFATC4 PPP3CA | Physiological and pathological hypertrophy of the heart |
| GO:0106058 | 0.00655807506899 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | positive regulation of calcineurin-mediated signaling |
| GO:0070886 | 0.00655807506899 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | positive regulation of calcineurin-NFAT signaling cascade |
| WP:WP2583 | 0.0070597840293 | 0.222222222222 | GSK3A PPP3CA | T cell receptor and co stimulatory signaling |
| KEGG:05417 | 0.00738827422101 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Lipid and atherosclerosis |
| REAC:R-HSA-111447 | 0.00835291407054 | 0.222222222222 | PPP3CC PPP3R1 | Activation of BAD and translocation to mitochondria |
| REAC:R-HSA-2871809 | 0.0135859457713 | 0.222222222222 | PPP3R1 PPP3CA | FCERI mediated Ca+2 mobilization |
| GO:0090279 | 0.0142113571615 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | regulation of calcium ion import |
| WP:WP2447 | 0.016080037976 | 0.222222222222 | PPP3CC PPP3CA | Amyotrophic lateral sclerosis ALS |
| GO:0098703 | 0.0162365457737 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | calcium ion import across plasma membrane |
| GO:1902656 | 0.0162365457737 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | calcium ion import into cytosol |
| KEGG:04010 | 0.0179039523177 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | MAPK signaling pathway |
| KEGG:05020 | 0.0183401415324 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Prion disease |
| WP:WP382 | 0.0184784380745 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | MAPK signaling pathway |
| GO:0035556 | 0.0214945809649 | 0.888888888889 | NFATC4 PPP3CC RCAN3 PPP3CA PPP3R1 RCAN2 GSK3A RCAN1 | intracellular signal transduction |
| WP:WP2059 | 0.0278432079517 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 0.0278432079517 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Alzheimer 39 s disease |
| GO:1903170 | 0.029267276266 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | negative regulation of calcium ion transmembrane transport |
| REAC:R-HSA-114452 | 0.0344394959621 | 0.222222222222 | PPP3CC PPP3R1 | Activation of BH3-only proteins |
| REAC:R-HSA-418594 | 0.0381598158281 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | G alpha (i) signalling events |
| GO:0141124 | 0.0384238217679 | 0.777777777778 | NFATC4 PPP3CC RCAN3 PPP3CA PPP3R1 RCAN2 RCAN1 | intracellular signaling cassette |
| GO:0050850 | 0.0396911574974 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | positive regulation of calcium-mediated signaling |
| KEGG:05014 | 0.0415121242062 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Amyotrophic lateral sclerosis |
| KEGG:05010 | 0.0477532154512 | 0.333333333333 | PPP3CC PPP3R1 PPP3CA | Alzheimer disease |
| CORUM:517 | 0.0499842271994 | 0.111111111111 | PPP3CA | AKAP5-PRKAR2A-PPP3CA complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RCAN3 | PPP3R1 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PPP3CC | RCAN1 | 1.0 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PPP3CA | RCAN1 | 1.0 | 0.106 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RCAN1 | PPP3R1 | 1.0 | 0.114 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PPP3CB | RCAN1 | 1.0 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RCAN3 | PPP3CB | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PPP3CC | PPP3R1 | 0.999 | 0.028 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RCAN3 | PPP3CC | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GSK3A | RCAN1 | 0.999 | 0.184 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RCAN3 | PPP3CA | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GSK3A | PPP3CC | 0.997 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PPP3CA | PPP3R1 | 0.997 | 0.354 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PPP3CB | RCAN2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PPP3R1 | RCAN2 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PPP3CC | RCAN2 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TNS4 | PPP3R1 | 0.992 | 0.044 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| PPP3CA | RCAN2 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PPP3CB | TNS4 | 0.987 | 0.082 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| PPP3CC | PPP3CB | 0.986 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GSK3A | PPP3CB | 0.984 | 0.232 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| PPP3CC | TNS4 | 0.98 | 0.078 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| PPP3CC | NFATC4 | 0.974 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PPP3CA | TNS4 | 0.971 | 0.05 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| PPP3CA | PPP3CB | 0.968 | 0.558 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| GSK3A | PPP3CA | 0.967 | 0.142 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PPP3CC | PPP3CA | 0.933 | 0.034 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RCAN3 | RCAN1 | 0.925 | bioplex_WMM bioplex3_WMM WMM_only | |
| PPP3CB | PPP3R1 | 0.925 | 0.492 | bioplex_WMM bioplex3_WMM WMM_only |
| GSK3A | PPP3R1 | 0.871 | 0.148 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| RCAN3 | NFATC4 | 0.825 | bioplex_WMM bioplex3_WMM WMM_only | |
| NFATC4 | PPP3CA | 0.488 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| NFATC4 | PPP3R1 | 0.4 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only |
| NFATC4 | RCAN1 | 0.367 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only |
| NFATC4 | PPP3CB | 0.235 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only |
| GSK3A | NFATC4 | 0.202 | 0.166 | bioplex_WMM bioplex3_WMM WMM_only |
| GSK3A | RCAN2 | 0.167 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| RCAN3 | GSK3A | 0.115 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes