hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06008.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LPIN1 | Phosphatidate phosphatase LPIN1 (EC 3.1.3.4) (Lipin-1) | 5 | UniProt NCBI |
| LPIN3 | Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) | 5 | UniProt NCBI |
| LPIN2 | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5275 | 5.27109902677e-08 | 1.0 | LPIN2 LPIN1 LPIN3 | Ether lipid biosynthesis |
| WP:WP5101 | 6.32531883213e-08 | 1.0 | LPIN2 LPIN1 LPIN3 | Congenital generalized lipodystrophy |
| REAC:R-HSA-1483213 | 7.69893532894e-08 | 1.0 | LPIN2 LPIN1 LPIN3 | Synthesis of PE |
| REAC:R-HSA-75109 | 1.02652471053e-07 | 1.0 | LPIN2 LPIN1 LPIN3 | Triglyceride biosynthesis |
| REAC:R-HSA-4419969 | 1.33448212368e-07 | 1.0 | LPIN2 LPIN1 LPIN3 | Depolymerization of the Nuclear Lamina |
| REAC:R-HSA-1483191 | 8.26352391973e-07 | 1.0 | LPIN2 LPIN1 LPIN3 | Synthesis of PC |
| KEGG:00561 | 1.22375439253e-06 | 1.0 | LPIN2 LPIN1 LPIN3 | Glycerolipid metabolism |
| REAC:R-HSA-8979227 | 2.31434662009e-06 | 1.0 | LPIN2 LPIN1 LPIN3 | Triglyceride metabolism |
| KEGG:00564 | 4.13101996102e-06 | 1.0 | LPIN2 LPIN1 LPIN3 | Glycerophospholipid metabolism |
| REAC:R-HSA-2980766 | 7.56595371871e-06 | 1.0 | LPIN2 LPIN1 LPIN3 | Nuclear Envelope Breakdown |
| WP:WP236 | 1.5385795446e-05 | 1.0 | LPIN2 LPIN1 LPIN3 | Adipogenesis |
| KEGG:04936 | 1.62006150102e-05 | 1.0 | LPIN2 LPIN1 LPIN3 | Alcoholic liver disease |
| GO:0008195 | 2.11464090368e-05 | 1.0 | LPIN2 LPIN1 LPIN3 | phosphatidate phosphatase activity |
| KEGG:04150 | 2.7655198514e-05 | 1.0 | LPIN2 LPIN1 LPIN3 | mTOR signaling pathway |
| GO:0042577 | 5.38272230028e-05 | 1.0 | LPIN2 LPIN1 LPIN3 | lipid phosphatase activity |
| REAC:R-HSA-1483206 | 8.74692373796e-05 | 1.0 | LPIN2 LPIN1 LPIN3 | Glycerophospholipid biosynthesis |
| REAC:R-HSA-68875 | 0.000137759616152 | 1.0 | LPIN2 LPIN1 LPIN3 | Mitotic Prophase |
| WP:WP2533 | 0.000397139561296 | 0.666666666667 | LPIN1 LPIN2 | Glycerophospholipid biosynthetic pathway |
| REAC:R-HSA-1483257 | 0.000416769032473 | 1.0 | LPIN2 LPIN1 LPIN3 | Phospholipid metabolism |
| GO:0019432 | 0.000524430944113 | 1.0 | LPIN2 LPIN1 LPIN3 | triglyceride biosynthetic process |
| GO:0046463 | 0.000810868666521 | 1.0 | LPIN2 LPIN1 LPIN3 | acylglycerol biosynthetic process |
| GO:0046460 | 0.000810868666521 | 1.0 | LPIN2 LPIN1 LPIN3 | neutral lipid biosynthetic process |
| REAC:R-HSA-68886 | 0.00447254250064 | 1.0 | LPIN2 LPIN1 LPIN3 | M Phase |
| GO:0006641 | 0.00460463056777 | 1.0 | LPIN2 LPIN1 LPIN3 | triglyceride metabolic process |
| GO:0009062 | 0.00731242824493 | 1.0 | LPIN2 LPIN1 LPIN3 | fatty acid catabolic process |
| GO:0072329 | 0.0101882437539 | 1.0 | LPIN2 LPIN1 LPIN3 | monocarboxylic acid catabolic process |
| REAC:R-HSA-69278 | 0.0112530904983 | 1.0 | LPIN2 LPIN1 LPIN3 | Cell Cycle, Mitotic |
| GO:0006639 | 0.0112921824257 | 1.0 | LPIN2 LPIN1 LPIN3 | acylglycerol metabolic process |
| GO:0006638 | 0.0112921824257 | 1.0 | LPIN2 LPIN1 LPIN3 | neutral lipid metabolic process |
| REAC:R-HSA-556833 | 0.0177385429708 | 1.0 | LPIN2 LPIN1 LPIN3 | Metabolism of lipids |
| KEGG:01100 | 0.0189521995452 | 1.0 | LPIN2 LPIN1 LPIN3 | Metabolic pathways |
| REAC:R-HSA-1640170 | 0.0209648611427 | 1.0 | LPIN2 LPIN1 LPIN3 | Cell Cycle |
| GO:0032869 | 0.0360123345897 | 1.0 | LPIN2 LPIN1 LPIN3 | cellular response to insulin stimulus |
| GO:0032868 | 0.0449053607901 | 1.0 | LPIN2 LPIN1 LPIN3 | response to insulin |
| CORUM:6090 | 0.0499402709677 | 0.333333333333 | LPIN1 | Seipin-lipin1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LPIN2 | LPIN3 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LPIN3 | LPIN1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | |
| LPIN2 | LPIN1 | 0.991 | 0.144 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes