hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06010.1

Complex Portal: CPX-17538

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
VPS37B	Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B)	5	UniProt NCBI
MVB12B	Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B)	5	UniProt NCBI
PDCD6IP	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)	5	UniProt NCBI
TSG101	Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)	5	UniProt NCBI
VPS28	Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28)	5	UniProt NCBI
UMAD1	UBAP1-MVB12-associated (UMA)-domain containing protein 1 (RPA3 antisense RNA 1) (RPA3 opposite strand)	2	UniProt NCBI
MVB12A	Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-162588	2.96622887934e-14	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	Budding and maturation of HIV virion
REAC:R-HSA-174495	1.46579079198e-12	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	Synthesis And Processing Of GAG, GAGPOL Polyproteins
REAC:R-HSA-174490	1.46579079198e-12	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	Membrane binding and targetting of GAG proteins
GO:0046755	2.61043832372e-12	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	viral budding
REAC:R-HSA-175474	3.19735900054e-12	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	Assembly Of The HIV Virion
GO:0036258	1.90309081662e-11	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	multivesicular body assembly
GO:0036257	2.34212799259e-11	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	multivesicular body organization
GO:0019068	2.34212799259e-11	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	virion assembly
GO:0000813	4.76240601112e-11	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	ESCRT I complex
REAC:R-HSA-917729	1.04147201904e-10	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	Endosomal Sorting Complex Required For Transport (ESCRT)
REAC:R-HSA-9615710	1.47137351502e-10	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	Late endosomal microautophagy
REAC:R-HSA-162599	5.93960172288e-10	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	Late Phase of HIV Life Cycle
GO:0043328	8.24918622139e-10	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
REAC:R-HSA-162587	1.01829084014e-09	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	HIV Life Cycle
GO:0039702	2.92667108476e-09	0.714285714286	TSG101 MVB12A VPS28 VPS37B PDCD6IP	viral budding via host ESCRT complex
GO:0032511	4.96990184286e-09	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	late endosome to vacuole transport via multivesicular body sorting pathway
KEGG:04144	5.27021627566e-09	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	Endocytosis
CORUM:1863	7.02338504734e-09	0.428571428571	TSG101 VPS37B VPS28	TSG101-VPS37B-VPS28 complex
GO:0007032	8.36385778743e-09	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	endosome organization
GO:0036452	1.00235603606e-08	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	ESCRT complex
REAC:R-HSA-162906	1.49698341815e-08	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	HIV Infection
GO:0045324	3.20336217802e-08	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	late endosome to vacuole transport
GO:0043162	4.47351531807e-08	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
REAC:R-HSA-9610379	5.18598397867e-08	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	HCMV Late Events
GO:0032509	5.24421182e-08	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	endosome transport via multivesicular body sorting pathway
GO:0071985	1.23927893001e-07	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	multivesicular body sorting pathway
GO:0090148	1.41123968224e-07	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	membrane fission
REAC:R-HSA-9612973	3.11939748367e-07	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	Autophagy
REAC:R-HSA-9609646	3.23287246817e-07	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	HCMV Infection
GO:0072666	5.39667862976e-07	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	establishment of protein localization to vacuole
GO:0019058	2.91752491674e-06	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	viral life cycle
GO:0072665	3.23760764817e-06	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	protein localization to vacuole
WP:WP4932	5.45894923866e-06	0.571428571429	TSG101 MVB12A VPS37B VPS28	7q11 23 copy number variation syndrome
REAC:R-HSA-9824446	1.57909646269e-05	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	Viral Infection Pathways
GO:0016050	1.65028399687e-05	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	vesicle organization
GO:0016032	2.98493789243e-05	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	viral process
REAC:R-HSA-5663205	5.40997884825e-05	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	Infectious disease
GO:0007034	5.76456118541e-05	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	vacuolar transport
CORUM:1192	6.1565588648e-05	0.285714285714	TSG101 VPS28	ESCRT-I complex
GO:0010256	0.000235784853066	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	endomembrane system organization
REAC:R-HSA-199991	0.000347098893962	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	Membrane Trafficking
REAC:R-HSA-5653656	0.000454173249089	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	Vesicle-mediated transport
GO:0061024	0.00110144128138	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	membrane organization
GO:0016197	0.00127236559123	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	endosomal transport
REAC:R-HSA-1643685	0.00135096746548	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	Disease
GO:0051603	0.00164290635638	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	proteolysis involved in protein catabolic process
GO:0016236	0.00223322150095	0.714285714286	TSG101 MVB12A VPS28 VPS37B PDCD6IP	macroautophagy
GO:0005768	0.00428640519627	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	endosome
GO:0070925	0.00523002441577	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	organelle assembly
GO:0072594	0.00659052366687	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	establishment of protein localization to organelle
GO:0030163	0.00675102177284	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	protein catabolic process
GO:0010008	0.00688674327254	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	endosome membrane
HPA:0550053	0.00742299915125	0.857142857143	VPS37B VPS28 PDCD6IP UMAD1 TSG101 MVB12A	stomach 2; glandular cells[High]
HPA:0540053	0.0076630153656	0.857142857143	VPS37B VPS28 PDCD6IP UMAD1 TSG101 MVB12A	stomach 1; glandular cells[High]
GO:0019075	0.00983221512175	0.285714285714	MVB12B MVB12A	virus maturation
KEGG:03250	0.0161758146638	0.285714285714	TSG101 PDCD6IP	Viral life cycle - HIV-1
HPA:0220053	0.0189814837133	0.857142857143	VPS37B VPS28 PDCD6IP UMAD1 TSG101 MVB12A	gallbladder; glandular cells[High]
GO:0061919	0.0261282499937	0.714285714286	TSG101 MVB12A VPS28 VPS37B PDCD6IP	process utilizing autophagic mechanism
GO:0006914	0.0261282499937	0.714285714286	TSG101 MVB12A VPS28 VPS37B PDCD6IP	autophagy
GO:1903772	0.0294899169624	0.285714285714	TSG101 VPS37B	regulation of viral budding via host ESCRT complex
GO:1903774	0.0294899169624	0.285714285714	TSG101 VPS37B	positive regulation of viral budding via host ESCRT complex
GO:0006886	0.0391846142903	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	intracellular protein transport
GO:0006511	0.0416503840831	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	ubiquitin-dependent protein catabolic process
GO:0009057	0.0443331067039	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	macromolecule catabolic process
GO:0019941	0.0451283589106	0.714285714286	MVB12B MVB12A VPS28 VPS37B TSG101	modification-dependent protein catabolic process
GO:0006508	0.045863009993	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	proteolysis
GO:1901565	0.0463826050405	0.857142857143	VPS37B VPS28 PDCD6IP MVB12B TSG101 MVB12A	organonitrogen compound catabolic process

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
MVB12A	VPS28	1.0	0.308	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction
TSG101	MVB12A	1.0	0.366		hein_WMM bioplex_WMM bioplex3_WMM hein () Malo fraction
VPS37B	TSG101	1.0	0.252		hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo fraction
VPS37B	VPS28	1.0	0.534		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 fraction
TSG101	VPS28	1.0	0.912		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction
MVB12B	VPS28	0.999	0.094		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PDCD6IP	MVB12A	0.997	0.118		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
VPS37B	MVB12A	0.997	0.268		hein_WMM bioplex_WMM bioplex3_WMM Malo fraction
UMAD1	VPS28	0.996	0.172		hein_WMM bioplex3_HEK293 bioplex3_WMM hein ()
TSG101	UMAD1	0.988	0.154		hein_WMM bioplex3_WMM WMM_only
PDCD6IP	TSG101	0.982	0.246666666667		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
UMAD1	MVB12A	0.981	0.054		hein_WMM bioplex3_WMM WMM_only
MVB12B	MVB12A	0.972	0.052		bioplex_WMM bioplex3_WMM WMM_only
PDCD6IP	UMAD1	0.963	0.096		hein_WMM bioplex3_WMM WMM_only
MVB12B	VPS37B	0.948	0.126		bioplex_WMM bioplex3_WMM fraction
VPS37B	UMAD1	0.844	0.062		hein_WMM bioplex3_WMM WMM_only
MVB12B	TSG101	0.839	0.072		bioplex_WMM bioplex3_WMM fraction
MVB12B	PDCD6IP	0.696	0.046		bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
PDCD6IP	VPS28	0.193	0.124		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
MVB12B	UMAD1	0.089	0.166		bioplex3_WMM WMM_only
VPS37B	PDCD6IP	0.01	0.11		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only

Related Complexes

Genename	Complexes
VPS37B	huMAP3_01514.1 huMAP3_06010.1 huMAP3_07951.1 huMAP3_09572.1 huMAP3_12917.1 huMAP3_13805.1
MVB12B	huMAP3_00501.1 huMAP3_04792.1 huMAP3_06010.1 huMAP3_06241.1 huMAP3_06316.1 huMAP3_07951.1 huMAP3_08364.1 huMAP3_09572.1 huMAP3_10226.1 huMAP3_12917.1 huMAP3_13805.1
PDCD6IP	huMAP3_01514.1 huMAP3_03988.1 huMAP3_06010.1 huMAP3_06089.1 huMAP3_06564.1 huMAP3_07951.1 huMAP3_08679.1 huMAP3_09572.1 huMAP3_10053.1 huMAP3_12409.1 huMAP3_12917.1 huMAP3_13805.1
TSG101	huMAP3_01514.1 huMAP3_06010.1 huMAP3_07951.1 huMAP3_08679.1 huMAP3_09572.1 huMAP3_10053.1 huMAP3_12917.1 huMAP3_13805.1
VPS28	huMAP3_04792.1 huMAP3_06010.1 huMAP3_06533.1 huMAP3_07951.1 huMAP3_09572.1 huMAP3_12917.1 huMAP3_13805.1
UMAD1	huMAP3_01514.1 huMAP3_03988.1 huMAP3_06010.1 huMAP3_06564.1 huMAP3_07951.1 huMAP3_08679.1 huMAP3_09572.1 huMAP3_10053.1 huMAP3_12917.1 huMAP3_13805.1
MVB12A	huMAP3_01514.1 huMAP3_06010.1 huMAP3_07951.1 huMAP3_09572.1 huMAP3_12917.1 huMAP3_13805.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06010.1

Complex Portal: CPX-17538