hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06014.1
Complex Portal: CPX-20100
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| COL4A5 | Collagen alpha-5(IV) chain | 5 | UniProt NCBI |
| COL17A1 | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | 5 | UniProt NCBI |
| COL4A1 | Collagen alpha-1(IV) chain [Cleaved into: Arresten] | 5 | UniProt NCBI |
| COL4A4 | Collagen alpha-4(IV) chain | 5 | UniProt NCBI |
| COL6A3 | Collagen alpha-3(VI) chain | 5 | UniProt NCBI |
| LAIR2 | Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) (CD antigen CD306) | 4 | UniProt NCBI |
| CCBE1 | Collagen and calcium-binding EGF domain-containing protein 1 (Full of fluid protein homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8948216 | 1.26352756558e-05 | 0.6 | COL4A1 COL17A1 COL4A4 | Collagen chain trimerization |
| KEGG:04974 | 4.85636233593e-05 | 0.6 | COL4A1 COL17A1 COL4A4 | Protein digestion and absorption |
| REAC:R-HSA-2022090 | 5.03751582702e-05 | 0.6 | COL4A1 COL17A1 COL4A4 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-1442490 | 5.72260849506e-05 | 0.6 | COL4A1 COL17A1 COL4A4 | Collagen degradation |
| REAC:R-HSA-1650814 | 6.86227830674e-05 | 0.6 | COL4A1 COL17A1 COL4A4 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-1474290 | 0.00018480745401 | 0.6 | COL4A1 COL17A1 COL4A4 | Collagen formation |
| REAC:R-HSA-1474228 | 0.000578912790256 | 0.6 | COL4A1 COL17A1 COL4A4 | Degradation of the extracellular matrix |
| REAC:R-HSA-2214320 | 0.0011839189519 | 0.4 | COL4A1 COL4A4 | Anchoring fibril formation |
| REAC:R-HSA-2243919 | 0.0018206657072 | 0.4 | COL4A1 COL4A4 | Crosslinking of collagen fibrils |
| GO:0030020 | 0.00350285844735 | 0.6 | COL4A1 COL17A1 COL4A4 | extracellular matrix structural constituent conferring tensile strength |
| REAC:R-HSA-3000157 | 0.00531742996423 | 0.4 | COL4A1 COL4A4 | Laminin interactions |
| REAC:R-HSA-419037 | 0.00531742996423 | 0.4 | COL4A1 COL4A4 | NCAM1 interactions |
| REAC:R-HSA-1474244 | 0.00594422623006 | 0.6 | COL4A1 COL17A1 COL4A4 | Extracellular matrix organization |
| KEGG:04512 | 0.00996128881886 | 0.4 | COL4A1 COL4A4 | ECM-receptor interaction |
| REAC:R-HSA-375165 | 0.0130168285242 | 0.4 | COL4A1 COL4A4 | NCAM signaling for neurite out-growth |
| KEGG:05222 | 0.0164241113683 | 0.4 | COL4A1 COL4A4 | Small cell lung cancer |
| KEGG:05146 | 0.0164241113683 | 0.4 | COL4A1 COL4A4 | Amoebiasis |
| KEGG:04933 | 0.0168082536599 | 0.4 | COL4A1 COL4A4 | AGE-RAGE signaling pathway in diabetic complications |
| REAC:R-HSA-3000171 | 0.0170393864121 | 0.4 | COL4A1 COL4A4 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-186797 | 0.0170393864121 | 0.4 | COL4A1 COL4A4 | Signaling by PDGF |
| WP:WP4658 | 0.0227605362571 | 0.4 | COL4A1 COL4A4 | Small cell lung cancer |
| REAC:R-HSA-3000178 | 0.0249357389386 | 0.4 | COL4A1 COL4A4 | ECM proteoglycans |
| KEGG:04926 | 0.0258857078716 | 0.4 | COL4A1 COL4A4 | Relaxin signaling pathway |
| REAC:R-HSA-216083 | 0.0294410858888 | 0.4 | COL4A1 COL4A4 | Integrin cell surface interactions |
| HP:0002215 | 0.0316815705386 | 0.4 | COL17A1 CCBE1 | Sparse axillary hair |
| HP:0000622 | 0.0425110382594 | 0.4 | COL4A1 COL17A1 | Blurred vision |
| HP:0200020 | 0.0425110382594 | 0.4 | COL17A1 COL4A4 | Corneal erosion |
| HP:0100134 | 0.0448666137641 | 0.4 | COL17A1 CCBE1 | Abnormality of the axillary hair |
| GO:0005587 | 0.0468008499735 | 0.4 | COL4A1 COL4A4 | collagen type IV trimer |
| WP:WP4239 | 0.0499562127809 | 0.4 | COL4A1 COL4A4 | Epithelial to mesenchymal transition in colorectal cancer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LAIR2 | COL4A1 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COL4A4 | LAIR2 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LAIR2 | COL4A5 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COL6A3 | LAIR2 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COL17A1 | LAIR2 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LAIR2 | CCBE1 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| COL4A5 | COL4A1 | 0.98 | bioplex_WMM bioplex3_WMM WMM_only | ||
| COL6A3 | COL4A1 | 0.904 | 0.626 | bioplex3_WMM WMM_only | |
| COL17A1 | COL4A1 | 0.904 | bioplex3_WMM WMM_only | ||
| COL6A3 | COL4A5 | 0.902 | bioplex3_WMM WMM_only | ||
| COL17A1 | COL6A3 | 0.902 | bioplex3_WMM WMM_only | ||
| COL17A1 | COL4A5 | 0.902 | bioplex3_WMM WMM_only | ||
| COL4A4 | COL6A3 | 0.902 | bioplex3_WMM WMM_only | ||
| COL17A1 | COL4A4 | 0.902 | bioplex3_WMM WMM_only | ||
| COL4A4 | COL4A1 | 0.796 | bioplex3_WMM WMM_only | ||
| COL4A4 | COL4A5 | 0.656 | bioplex3_WMM WMM_only | ||
| COL4A4 | CCBE1 | 0.415 | bioplex3_WMM WMM_only | ||
| COL17A1 | CCBE1 | 0.214 | bioplex3_WMM WMM_only | ||
| COL6A3 | CCBE1 | 0.214 | bioplex3_WMM WMM_only | ||
| CCBE1 | COL4A5 | 0.131 | bioplex3_WMM WMM_only | ||
| CCBE1 | COL4A1 | 0.113 | bioplex3_WMM WMM_only |
Related Complexes