hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06017.1
Complex Portal: CPX-15691
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MYH9 | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | 5 | UniProt NCBI |
| SYNPO | Synaptopodin | 5 | UniProt NCBI |
| MYH10 | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | 5 | UniProt NCBI |
| JMY | Junction-mediating and -regulatory protein | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04530 | 0.000149305865271 | 0.75 | MYH9 SYNPO MYH10 | Tight junction |
| WP:WP4758 | 0.00169541860832 | 0.5 | MYH9 SYNPO | Nephrotic syndrome |
| REAC:R-HSA-416572 | 0.00175047124894 | 0.5 | MYH9 MYH10 | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-5625900 | 0.00175047124894 | 0.5 | MYH9 MYH10 | RHO GTPases activate CIT |
| REAC:R-HSA-5627117 | 0.00175047124894 | 0.5 | MYH9 MYH10 | RHO GTPases Activate ROCKs |
| REAC:R-HSA-5627123 | 0.00194479046925 | 0.5 | MYH9 MYH10 | RHO GTPases activate PAKs |
| REAC:R-HSA-400685 | 0.00258893271292 | 0.5 | MYH9 MYH10 | Sema4D in semaphorin signaling |
| REAC:R-HSA-3928663 | 0.00332479301982 | 0.5 | MYH9 MYH10 | EPHA-mediated growth cone collapse |
| WP:WP2572 | 0.00480287938686 | 0.5 | MYH9 SYNPO | Primary focal segmental glomerulosclerosis FSGS |
| GO:0097513 | 0.00842684400117 | 0.5 | MYH9 MYH10 | myosin II filament |
| GO:0001725 | 0.00951168180783 | 0.75 | MYH9 SYNPO MYH10 | stress fiber |
| GO:0097517 | 0.00951168180783 | 0.75 | MYH9 SYNPO MYH10 | contractile actin filament bundle |
| KEGG:04270 | 0.0113396114984 | 0.5 | MYH9 MYH10 | Vascular smooth muscle contraction |
| GO:0032432 | 0.0124631389739 | 0.75 | MYH9 SYNPO MYH10 | actin filament bundle |
| GO:0042641 | 0.0131184183431 | 0.75 | MYH9 SYNPO MYH10 | actomyosin |
| REAC:R-HSA-373755 | 0.0174510452107 | 0.5 | MYH9 MYH10 | Semaphorin interactions |
| KEGG:04814 | 0.0322340970049 | 0.5 | MYH9 MYH10 | Motor proteins |
| REAC:R-HSA-5625740 | 0.0329793636325 | 0.5 | MYH9 MYH10 | RHO GTPases activate PKNs |
| KEGG:05130 | 0.0334335704012 | 0.5 | MYH9 MYH10 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-2682334 | 0.0338007536087 | 0.5 | MYH9 MYH10 | EPH-Ephrin signaling |
| KEGG:04810 | 0.0466115978004 | 0.5 | MYH9 MYH10 | Regulation of actin cytoskeleton |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MYH9 | JMY | 0.982 | 0.222 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| MYH9 | MYH10 | 0.973 | 0.507 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM treiber_WMM | |
| JMY | MYH10 | 0.973 | 0.072 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MYH9 | SYNPO | 0.969 | hein_WMM hein () | ||
| SYNPO | MYH10 | 0.15 | hein_WMM hein () | ||
| SYNPO | JMY | 0.063 | hein_WMM WMM_only |
Related Complexes