hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06040.1

Complex Portal: CPX-19398

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
RNF2	E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)	5	UniProt NCBI
CBX8	Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)	5	UniProt NCBI
BCOR	BCL-6 corepressor (BCoR)	5	UniProt NCBI
YAF2	YY1-associated factor 2	5	UniProt NCBI
RING1	E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)	5	UniProt NCBI
KDM2B	Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B)	5	UniProt NCBI
PCGF3	Polycomb group RING finger protein 3 (RING finger protein 3A)	5	UniProt NCBI
CBX4	E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)	5	UniProt NCBI
BCORL1	BCL-6 corepressor-like protein 1 (BCoR-L1) (BCoR-like protein 1)	5	UniProt NCBI
FBRS	Probable fibrosin-1	2	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:03083	7.74318099223e-22	1.0	FBRS KDM2B RNF2 RING1 BCOR CBX4 CBX8 PCGF3 BCORL1 YAF2	Polycomb repressive complex
CORUM:1178	2.82054434053e-10	0.4	RNF2 KDM2B BCOR RING1	BCOR complex
CORUM:116	2.6558767977e-09	0.4	CBX4 RNF2 CBX8 RING1	Polycomb repressive complex 1 (PRC1, hPRC-H)
CORUM:115	2.6558767977e-09	0.4	CBX4 RNF2 CBX8 RING1	Polycomb repressive complex 1 (PRC1, hPRC-H)
GO:0031519	4.03935480232e-09	0.6	CBX4 RNF2 RING1 CBX8 PCGF3 KDM2B	PcG protein complex
REAC:R-HSA-8939243	4.09612895943e-09	0.5	CBX4 RNF2 CBX8 RING1 YAF2	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
GO:0000152	5.43304786034e-09	0.6	CBX4 RNF2 RING1 CBX8 PCGF3 BCOR	nuclear ubiquitin ligase complex
GO:0035102	9.88040022132e-09	0.5	CBX4 RNF2 PCGF3 CBX8 RING1	PRC1 complex
REAC:R-HSA-4655427	3.63057874925e-08	0.4	CBX4 RNF2 CBX8 RING1	SUMOylation of DNA methylation proteins
REAC:R-HSA-3899300	1.94851007479e-06	0.4	CBX4 RNF2 CBX8 RING1	SUMOylation of transcription cofactors
REAC:R-HSA-4570464	3.25232382974e-06	0.4	CBX4 RNF2 CBX8 RING1	SUMOylation of RNA binding proteins
CORUM:1194	3.69251717673e-06	0.3	RNF2 YAF2 RING1	E2F-6 complex
REAC:R-HSA-8943724	1.0362148401e-05	0.4	CBX4 RNF2 CBX8 RING1	Regulation of PTEN gene transcription
REAC:R-HSA-4551638	1.88504115072e-05	0.4	CBX4 RNF2 CBX8 RING1	SUMOylation of chromatin organization proteins
REAC:R-HSA-3108214	2.53712544894e-05	0.4	CBX4 RNF2 CBX8 RING1	SUMOylation of DNA damage response and repair proteins
REAC:R-HSA-8878171	3.43347437563e-05	0.5	CBX4 RNF2 CBX8 RING1 YAF2	Transcriptional regulation by RUNX1
CORUM:929	9.96450861922e-05	0.3	RNF2 CBX8 RING1	CEN complex
WP:WP4553	0.0001114513301	0.3	RNF2 BCOR KDM2B	FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma
REAC:R-HSA-2559580	0.000133163090441	0.4	CBX4 RNF2 CBX8 RING1	Oxidative Stress Induced Senescence
CORUM:1462	0.000184411585051	0.2	RNF2 RING1	hPRC1L complex
CORUM:5513	0.000184411585051	0.2	RING1 CBX4	RING1-Polycomb repressive complex
GO:0045892	0.000295220752062	0.8	KDM2B RNF2 RING1 BCOR CBX4 CBX8 BCORL1 YAF2	negative regulation of DNA-templated transcription
GO:1902679	0.000323360226327	0.8	KDM2B RNF2 RING1 BCOR CBX4 CBX8 BCORL1 YAF2	negative regulation of RNA biosynthetic process
REAC:R-HSA-8953750	0.000329743401167	0.3	RNF2 YAF2 RING1	Transcriptional Regulation by E2F6
REAC:R-HSA-6807070	0.00033831399581	0.4	CBX4 RNF2 CBX8 RING1	PTEN Regulation
GO:0000151	0.000442167221848	0.6	CBX4 RNF2 RING1 CBX8 PCGF3 BCOR	ubiquitin ligase complex
GO:0010558	0.000558202093732	0.9	KDM2B RNF2 RING1 BCOR CBX4 CBX8 PCGF3 BCORL1 YAF2	negative regulation of macromolecule biosynthetic process
REAC:R-HSA-3108232	0.000634112853678	0.4	CBX4 RNF2 CBX8 RING1	SUMO E3 ligases SUMOylate target proteins
GO:0031327	0.000681844520425	0.9	KDM2B RNF2 RING1 BCOR CBX4 CBX8 PCGF3 BCORL1 YAF2	negative regulation of cellular biosynthetic process
GO:0051253	0.000701634643935	0.8	KDM2B RNF2 RING1 BCOR CBX4 CBX8 BCORL1 YAF2	negative regulation of RNA metabolic process
REAC:R-HSA-2990846	0.000717932593717	0.4	CBX4 RNF2 CBX8 RING1	SUMOylation
GO:0009890	0.000718388187591	0.9	KDM2B RNF2 RING1 BCOR CBX4 CBX8 PCGF3 BCORL1 YAF2	negative regulation of biosynthetic process
REAC:R-HSA-2559583	0.0009525163043	0.4	CBX4 RNF2 CBX8 RING1	Cellular Senescence
GO:0045934	0.0015512419831	0.8	KDM2B RNF2 RING1 BCOR CBX4 CBX8 BCORL1 YAF2	negative regulation of nucleobase-containing compound metabolic process
REAC:R-HSA-1257604	0.00281396441165	0.4	CBX4 RNF2 CBX8 RING1	PIP3 activates AKT signaling
GO:0031324	0.00341514712729	0.9	KDM2B RNF2 RING1 BCOR CBX4 CBX8 PCGF3 BCORL1 YAF2	negative regulation of cellular metabolic process
GO:0010605	0.00403907974849	0.9	KDM2B RNF2 RING1 BCOR CBX4 CBX8 PCGF3 BCORL1 YAF2	negative regulation of macromolecule metabolic process
REAC:R-HSA-9006925	0.0049187431515	0.4	CBX4 RNF2 CBX8 RING1	Intracellular signaling by second messengers
GO:0009892	0.0080804186046	0.9	KDM2B RNF2 RING1 BCOR CBX4 CBX8 PCGF3 BCORL1 YAF2	negative regulation of metabolic process
GO:0006355	0.0260722421898	0.9	KDM2B RNF2 RING1 BCOR CBX4 CBX8 PCGF3 BCORL1 YAF2	regulation of DNA-templated transcription
GO:2001141	0.0275042486783	0.9	KDM2B RNF2 RING1 BCOR CBX4 CBX8 PCGF3 BCORL1 YAF2	regulation of RNA biosynthetic process
GO:0051172	0.0278057216294	0.8	KDM2B RNF2 RING1 BCOR CBX4 CBX8 BCORL1 YAF2	negative regulation of nitrogen compound metabolic process
HP:0000577	0.0284132342749	0.3	RNF2 BCOR BCORL1	Exotropia
GO:0006351	0.0396319173816	0.9	KDM2B RNF2 RING1 BCOR CBX4 CBX8 PCGF3 BCORL1 YAF2	DNA-templated transcription
HP:0020049	0.0408686292444	0.3	RNF2 BCOR BCORL1	Exodeviation
GO:0032774	0.0435543173798	0.9	KDM2B RNF2 RING1 BCOR CBX4 CBX8 PCGF3 BCORL1 YAF2	RNA biosynthetic process
GO:0000122	0.0497136062027	0.6	CBX4 RNF2 BCOR CBX8 BCORL1 KDM2B	negative regulation of transcription by RNA polymerase II

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
YAF2	RNF2	1.0	0.124		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
YAF2	RING1	1.0	0.112		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
RING1	FBRS	1.0	0.07		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () boldt_WMM
YAF2	FBRS	1.0	0.19		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
YAF2	PCGF3	0.999	0.12	structurally_consistent (Q86SE9) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RNF2	FBRS	0.999	0.1		hein_WMM bioplex_WMM bioplex3_WMM boldt hein () gupta_WMM boldt_WMM
CBX4	RING1	0.999	0.328		hein_WMM bioplex_WMM bioplex3_WMM hein ()
RNF2	CBX4	0.999	0.316		hein_WMM bioplex_WMM bioplex3_WMM hein ()
CBX8	CBX4	0.999	0.536		hein_WMM bioplex_WMM bioplex3_WMM hein ()
RING1	PCGF3	0.998	0.08		bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only
CBX8	RING1	0.998	0.248		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
RNF2	CBX8	0.998	0.228		hein_WMM bioplex_WMM bioplex3_WMM hein ()
RNF2	RING1	0.998	0.174		hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM
PCGF3	FBRS	0.998	0.144		bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
RNF2	PCGF3	0.997	0.096		bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only
BCORL1	RING1	0.997	0.066		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
YAF2	BCOR	0.996	0.158		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein ()
KDM2B	YAF2	0.995	0.126		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
BCORL1	BCOR	0.994	0.196		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
KDM2B	BCOR	0.993	0.254		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM
CBX8	BCOR	0.992	0.28		hein_WMM bioplex3_WMM youn_WMM WMM_only
CBX8	FBRS	0.992	0.134		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
RNF2	BCOR	0.99	0.172		hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM
KDM2B	RING1	0.985	0.142		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
BCOR	RING1	0.982	0.166		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM
BCORL1	YAF2	0.982	0.098		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
KDM2B	RNF2	0.979	0.15		hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM
KDM2B	BCORL1	0.967	0.18		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
BCORL1	RNF2	0.952	0.11		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
CBX4	FBRS	0.945	0.156		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
BCOR	FBRS	0.941	0.194		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
KDM2B	FBRS	0.937	0.092		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
BCOR	CBX4	0.905	0.266		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
YAF2	CBX8	0.845	0.078		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
BCORL1	FBRS	0.755	0.156		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
YAF2	CBX4	0.679	0.254		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
BCORL1	CBX4	0.425	0.166		bioplex_WMM bioplex3_WMM WMM_only
KDM2B	PCGF3	0.291	0.13		bioplex_WMM bioplex3_WMM WMM_only
BCOR	PCGF3	0.254	0.16		bioplex_WMM bioplex3_WMM WMM_only
BCORL1	CBX8	0.222	0.172		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
BCORL1	PCGF3	0.209	0.14		bioplex_WMM bioplex3_WMM WMM_only
KDM2B	CBX8	0.063	0.14		hein_WMM bioplex3_WMM youn_WMM WMM_only
KDM2B	CBX4	0.036	0.278		hein_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
RNF2	huMAP3_02464.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_14051.1
CBX8	huMAP3_02464.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09551.1 huMAP3_10162.1 huMAP3_14051.1
BCOR	huMAP3_02464.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_14051.1
YAF2	huMAP3_01807.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_14051.1
RING1	huMAP3_04542.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_14051.1
KDM2B	huMAP3_00161.1 huMAP3_00839.1 huMAP3_04542.1 huMAP3_05528.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09623.1 huMAP3_09719.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_14051.1 huMAP3_14622.1
PCGF3	huMAP3_04542.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_11527.1 huMAP3_11826.1 huMAP3_14051.1
CBX4	huMAP3_02464.1 huMAP3_06040.1 huMAP3_07970.1 huMAP3_09551.1 huMAP3_10162.1 huMAP3_12540.1 huMAP3_14051.1 huMAP3_14179.1
BCORL1	huMAP3_01807.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_13766.1 huMAP3_14051.1
FBRS	huMAP3_04542.1 huMAP3_06040.1 huMAP3_08622.1 huMAP3_09756.1 huMAP3_10162.1 huMAP3_11527.1 huMAP3_11826.1 huMAP3_14051.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06040.1

Complex Portal: CPX-19398