hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06042.1

Complex Portal: CPX-12075

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
TSEN54	tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54)	5	UniProt NCBI
TSEN15	tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15)	5	UniProt NCBI
PHLDA2	Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein) (p17-Beckwith-Wiedemann region 1 C) (p17-BWR1C)	5	UniProt NCBI
CLP1	Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polyadenylation factor Clp1) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1)	5	UniProt NCBI
PCF11	Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11)	5	UniProt NCBI
TSEN2	tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2)	5	UniProt NCBI
TSEN34	tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5283	3.94764526792e-16	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	tRNA splicing endonuclease
HP:0006850	2.34060903825e-10	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Hypoplasia of the ventral pons
HP:0012765	2.34060903825e-10	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Widened cerebellar subarachnoid space
HP:0200049	1.09192536551e-09	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Upper limb hypertonia
REAC:R-HSA-6784531	2.53511612092e-09	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	tRNA processing in the nucleus
HP:0003558	5.14511127683e-09	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Viral infection-induced rhabdomyolysis
CORUM:5284	7.02338504734e-09	0.428571428571	TSEN2 TSEN54 CLP1	RNA endonuclease (SEN2deltaEx8, SEN54, CLP1)
HP:0031162	7.71639876729e-09	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Impaired oropharyngeal swallow response
HP:0002268	3.70705924678e-08	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Paroxysmal dystonia
REAC:R-HSA-72306	5.18598397867e-08	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	tRNA processing
HP:0000253	9.2227741024e-08	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Progressive microcephaly
HP:0011171	9.31603571786e-08	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Simple febrile seizure
GO:0006388	3.03561565333e-07	0.571428571429	TSEN2 TSEN54 TSEN34 CLP1	tRNA splicing, via endonucleolytic cleavage and ligation
GO:0000394	4.5526752727e-07	0.571428571429	TSEN2 TSEN54 TSEN34 CLP1	RNA splicing, via endonucleolytic cleavage and ligation
HP:0006895	6.3569022244e-07	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Lower limb hypertonia
HP:0003201	1.27650452211e-06	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Rhabdomyolysis
HP:0012704	1.27650452211e-06	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Widened subarachnoid space
HP:0200136	1.27650452211e-06	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Oral-pharyngeal dysphagia
HP:0002509	1.41369677422e-06	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Limb hypertonia
HP:0025190	1.41810497204e-06	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Bilateral tonic-clonic seizure with generalized onset
HP:0100704	1.46474928031e-06	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Cerebral visual impairment
HP:0006989	1.57115503045e-06	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Dysplastic corpus callosum
HP:0009062	1.73625399626e-06	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Infantile axial hypotonia
GO:0000379	3.36420143768e-06	0.428571428571	TSEN54 TSEN34 TSEN2	tRNA-type intron splice site recognition and cleavage
GO:0000214	3.36420143768e-06	0.428571428571	TSEN2 TSEN54 CLP1	tRNA-intron endonuclease complex
HP:0005484	4.42100566012e-06	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Secondary microcephaly
HP:0007598	5.27912158282e-06	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Bilateral single transverse palmar creases
REAC:R-HSA-8953854	1.34047597764e-05	0.857142857143	TSEN2 TSEN34 TSEN54 TSEN15 PCF11 CLP1	Metabolism of RNA
HP:0012703	1.97903117197e-05	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Abnormal subarachnoid space morphology
HP:0002365	2.1995820962e-05	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Hypoplasia of the brainstem
HP:0012110	2.1995820962e-05	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Hypoplasia of the pons
HP:0007362	2.1995820962e-05	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Aplasia/Hypoplasia of the brainstem
HP:0002363	2.24663431244e-05	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Abnormal brainstem morphology
HP:0011471	3.42729351137e-05	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Gastrostomy tube feeding in infancy
HP:0008936	4.53172919886e-05	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Axial hypotonia
HP:0007361	5.55187626829e-05	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Abnormal pons morphology
HP:0001266	7.06007150711e-05	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Choreoathetosis
HP:0032894	0.00010595640629	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Seizure precipitated by febrile infection
HP:0032892	0.00010595640629	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Infection-related seizure
HP:0002373	0.00010595640629	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Febrile seizure (within the age range of 3 months to 6 years)
HP:0002536	0.000116724462246	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Abnormal cortical gyration
HP:0002123	0.000134461885723	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Generalized myoclonic seizure
HP:0002033	0.000148288378179	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Poor suck
HP:0012469	0.0001846657007	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Infantile spasms
HP:0002305	0.000276962997845	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Athetosis
HP:0002079	0.000298806874348	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Hypoplasia of the corpus callosum
HP:0002350	0.000300541855379	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Cerebellar cyst
HP:0002269	0.000324869105967	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Abnormality of neuronal migration
HP:0002020	0.000400264630257	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Gastroesophageal reflux
HP:0032677	0.000463647652621	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Generalized-onset motor seizure
HP:0000340	0.000474946842546	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Sloping forehead
HP:0011097	0.000547117486089	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Epileptic spasm
HP:0008947	0.000627174236895	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Infantile muscular hypotonia
HP:0033454	0.000670330232701	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Tube feeding
HP:0000954	0.000700306583593	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Single transverse palmar crease
HP:0010576	0.00074713218725	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Intracranial cystic lesion
HP:0030724	0.000779621016095	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Central nervous system cyst
HP:0011344	0.000813152365598	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Severe global developmental delay
HP:0002104	0.00110009942968	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Apnea
HP:0002072	0.00118794299453	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Chorea
HP:0009127	0.001272976415	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Abnormality of the musculature of the limbs
HP:0032794	0.0013049791219	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Myoclonic seizure
HP:0010490	0.00143040270982	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Abnormality of the palmar creases
HP:0001018	0.00156459889415	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Abnormal palmar dermatoglyphics
CORUM:1141	0.00159705726664	0.285714285714	CLP1 PCF11	CF IIAm complex (Cleavage factor IIAm complex)
HP:0002438	0.00179854424952	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Cerebellar malformation
HP:0001446	0.00182951922376	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Abnormality of the musculature of the upper limbs
HP:0007308	0.00249743559672	0.285714285714	TSEN54 TSEN2	Extrapyramidal dyskinesia
HP:0001320	0.00253658569138	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Cerebellar vermis hypoplasia
HP:0003487	0.00261704338105	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Babinski sign
HP:0031828	0.00261704338105	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Abnormal superficial reflex
HP:0002119	0.00333685801703	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Ventriculomegaly
HP:0007477	0.00337996576976	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Abnormal dermatoglyphics
HP:0007370	0.00351193913333	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Aplasia/Hypoplasia of the corpus callosum
HP:0006817	0.00358121595245	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Aplasia/Hypoplasia of the cerebellar vermis
HP:0002538	0.00388394682689	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Abnormal cerebral cortex morphology
HP:0002197	0.00423865852921	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Generalized-onset seizure
GO:0008033	0.00582419192488	0.571428571429	TSEN2 TSEN54 TSEN34 CLP1	tRNA processing
HP:0033725	0.00588607227615	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Thin corpus callosum
HP:0025270	0.00628050156579	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Abnormal esophagus physiology
HP:0002334	0.00643050545945	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Abnormal cerebellar vermis morphology
REAC:R-HSA-77595	0.0064914715634	0.285714285714	CLP1 PCF11	Processing of Intronless Pre-mRNAs
HP:0002069	0.00708969145237	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Bilateral tonic-clonic seizure
HP:0001257	0.00797447991426	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Spasticity
HP:0040211	0.00836238378055	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Abnormal skin morphology of the palm
HP:0001273	0.00857848314082	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Abnormal corpus callosum morphology
HP:0001270	0.00972222521101	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Motor delay
GO:0000213	0.00983221512175	0.285714285714	TSEN2 TSEN34	tRNA-intron endonuclease activity
HP:0002118	0.0101883810368	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Abnormal cerebral ventricle morphology
HP:0020219	0.0122824922986	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Motor seizure
HP:0007256	0.0129372325986	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Abnormal pyramidal sign
REAC:R-HSA-75067	0.0133002920771	0.285714285714	CLP1 PCF11	Processing of Capped Intronless Pre-mRNA
GO:1902555	0.0150353457168	0.428571428571	TSEN2 TSEN54 CLP1	endoribonuclease complex
HP:0001321	0.016606844302	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Cerebellar hypoplasia
HP:0000505	0.0185906818607	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Visual impairment
HP:0002360	0.0186188605393	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Sleep abnormality
HP:0100871	0.0189709720562	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Abnormal palm morphology
HP:0002500	0.0196649485966	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Abnormal cerebral white matter morphology
GO:1905348	0.0218744047191	0.428571428571	TSEN2 TSEN54 CLP1	endonuclease complex
HP:0001276	0.0236432482893	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Hypertonia
HP:0002015	0.0240113377476	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Dysphagia
HP:0011968	0.0244625952771	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Feeding difficulties
HP:0001332	0.0255228404391	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Dystonia
HP:0011356	0.0259673377146	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Regional abnormality of skin
HP:0000290	0.0271846378781	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Abnormality of the forehead
HP:0012719	0.0275736169282	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Functional abnormality of the gastrointestinal tract
HP:0010993	0.0284983301401	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Abnormal cerebral subcortex morphology
HP:0007360	0.0292411387003	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Aplasia/Hypoplasia of the cerebellum
HP:0002493	0.0295849322776	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Upper motor neuron dysfunction
HP:0031826	0.0317102836244	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Abnormal reflex
HP:0007663	0.0341603212271	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Reduced visual acuity
GO:0006399	0.0361823866547	0.571428571429	TSEN2 TSEN54 TSEN34 CLP1	tRNA metabolic process
HP:0008872	0.0390575540075	0.571428571429	TSEN2 TSEN54 TSEN34 TSEN15	Feeding difficulties in infancy
KEGG:03015	0.0411825364664	0.285714285714	CLP1 PCF11	mRNA surveillance pathway
HP:0000504	0.0419888091067	0.714285714286	TSEN2 TSEN54 CLP1 TSEN34 TSEN15	Abnormality of vision

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
TSEN15	TSEN34	1.0	0.22		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction
TSEN15	TSEN2	0.999	0.084	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLP1	TSEN2	0.999	0.166		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN2	TSEN34	0.999	0.108		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN2	TSEN54	0.999	0.116	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLP1	TSEN54	0.999	0.124	structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
TSEN15	CLP1	0.998	0.07		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLP1	TSEN34	0.998	0.12		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
CLP1	PCF11	0.997	0.27	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction
TSEN15	TSEN54	0.994	0.098	structurally_consistent (Q8NCE0)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TSEN34	TSEN54	0.971	0.156		bioplex_WMM bioplex3_WMM WMM_only
PHLDA2	CLP1	0.952	0.062		hein_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
TSEN15	PCF11	0.796	0.05		bioplex3_WMM youn_WMM WMM_only
PCF11	TSEN54	0.287	0.134	mutually_exclusive (Q92989)	bioplex3_WMM WMM_only
PCF11	TSEN34	0.215	0.056		bioplex3_WMM youn_WMM WMM_only
PCF11	TSEN2	0.209	0.09		bioplex3_WMM WMM_only
PHLDA2	PCF11	0.135	0.058		bioplex3_WMM WMM_only
PHLDA2	TSEN2	0.122	0.062		bioplex3_WMM WMM_only
TSEN15	PHLDA2	0.086	0.08		bioplex3_WMM WMM_only
PHLDA2	TSEN54	0.069	0.08		bioplex3_WMM WMM_only
PHLDA2	TSEN34	0.063	0.064		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
TSEN54	huMAP3_04582.1 huMAP3_06042.1 huMAP3_07243.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
TSEN15	huMAP3_02940.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14576.1 huMAP3_14586.1 huMAP3_14839.1 huMAP3_15245.1
PHLDA2	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_11956.1 huMAP3_13483.1 huMAP3_13693.1 huMAP3_14586.1 huMAP3_14839.1 huMAP3_14984.1
CLP1	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_14586.1 huMAP3_14839.1
PCF11	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_12111.1 huMAP3_13730.1 huMAP3_14483.1 huMAP3_14586.1
TSEN2	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
TSEN34	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06042.1

Complex Portal: CPX-12075