hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06061.1
Complex Portal: CPX-19020
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MCMBP | Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) | 5 | UniProt NCBI |
| MCM2 | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | 5 | UniProt NCBI |
| MCM6 | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | 5 | UniProt NCBI |
| MCM7 | DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) | 5 | UniProt NCBI |
| MCM4 | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2792 | 3.41752350426e-06 | 0.666666666667 | MCM2 MCM6 | MCM2-MCM4-MCM6-MCM7 complex |
| CORUM:1452 | 3.41752350426e-06 | 0.666666666667 | MCM2 MCM6 | MCM2-MCM6-MCM7 complex |
| CORUM:387 | 3.41752350426e-06 | 0.666666666667 | MCM2 MCM6 | MCM complex |
| GO:0042555 | 1.58598067776e-05 | 1.0 | MCM2 MCMBP MCM6 | MCM complex |
| CORUM:5611 | 0.000187886616059 | 0.666666666667 | MCM2 MCM6 | Emerin complex 24 |
| REAC:R-HSA-176974 | 0.000449812862905 | 0.666666666667 | MCM2 MCM6 | Unwinding of DNA |
| KEGG:03030 | 0.000480177590636 | 0.666666666667 | MCM2 MCM6 | DNA replication |
| WP:WP466 | 0.000973512535349 | 0.666666666667 | MCM2 MCM6 | DNA replication |
| WP:WP45 | 0.00227715198732 | 0.666666666667 | MCM2 MCM6 | G1 to S cell cycle control |
| REAC:R-HSA-69190 | 0.0033773260227 | 0.666666666667 | MCM2 MCM6 | DNA strand elongation |
| REAC:R-HSA-68962 | 0.00359505378021 | 0.666666666667 | MCM2 MCM6 | Activation of the pre-replicative complex |
| REAC:R-HSA-176187 | 0.00428896488724 | 0.666666666667 | MCM2 MCM6 | Activation of ATR in response to replication stress |
| HPA:0030433 | 0.00655950129524 | 0.666666666667 | MCM2 MCM6 | appendix; germinal center cells[High] |
| WP:WP179 | 0.00751610583681 | 0.666666666667 | MCM2 MCM6 | Cell cycle |
| KEGG:04110 | 0.00858640718729 | 0.666666666667 | MCM2 MCM6 | Cell cycle |
| REAC:R-HSA-68949 | 0.0164154902665 | 0.666666666667 | MCM2 MCM6 | Orc1 removal from chromatin |
| WP:WP4352 | 0.0243888015773 | 0.666666666667 | MCM2 MCM6 | Ciliary landscape |
| CORUM:2791 | 0.0249718442456 | 0.333333333333 | MCM6 | MCM4-MCM6-MCM7 complex |
| REAC:R-HSA-69052 | 0.0271982878007 | 0.666666666667 | MCM2 MCM6 | Switching of origins to a post-replicative state |
| HPA:0030432 | 0.0366451526634 | 0.666666666667 | MCM2 MCM6 | appendix; germinal center cells[>=Medium] |
| GO:0006261 | 0.0439566559847 | 1.0 | MCM2 MCMBP MCM6 | DNA-templated DNA replication |
| REAC:R-HSA-69239 | 0.0476168581556 | 0.666666666667 | MCM2 MCM6 | Synthesis of DNA |
| CORUM:6261 | 0.0499402709677 | 0.333333333333 | MCM2 | Histone-2-Histone-4-ASF1-MCM2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MCM6 | MCM4 | 1.0 | 0.986 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM boldt hein () Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM2 | MCM6 | 1.0 | 0.992 |
mutually_exclusive (Q9BTE3)
|
hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| MCM2 | MCM4 | 1.0 | 0.992 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM | |
| MCM4 | MCM7 | 1.0 | 0.988 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM6 | MCM7 | 0.999 | 0.974 |
mutually_exclusive (Q9BTE3)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM2 | MCM7 | 0.999 | 0.98 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM | |
| MCMBP | MCM6 | 0.998 | 0.304 |
mixed_interface
|
hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction treiber_WMM |
| MCMBP | MCM7 | 0.996 | 0.396 |
mutually_exclusive (P33991)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM Malo gupta_WMM fraction treiber_WMM |
| MCMBP | MCM2 | 0.987 | 0.207047619048 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM treiber_WMM WMM_only |
| MCMBP | MCM4 | 0.98 | 0.436 |
mutually_exclusive (Q14566)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM |
Related Complexes