hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06077.1

Complex Portal: CPX-10880

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
HOOK2	Protein Hook homolog 2 (h-hook2) (hHK2)	5	UniProt NCBI
XPO4	Exportin-4 (Exp4)	5	UniProt NCBI
TNPO2	Transportin-2 (Karyopherin beta-2b)	5	UniProt NCBI
PEX19	Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein)	5	UniProt NCBI
KNTC1	Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod)	5	UniProt NCBI
BTNL9	Butyrophilin-like protein 9	5	UniProt NCBI
XPO5	Exportin-5 (Exp5) (Ran-binding protein 21)	5	UniProt NCBI
XPO7	Exportin-7 (Exp7) (Ran-binding protein 16)	5	UniProt NCBI
GSDME	Gasdermin-E (Inversely correlated with estrogen receptor expression 1) (ICERE-1) (Non-syndromic hearing impairment protein 5) [Cleaved into: Gasdermin-E, N-terminal (GSDME-NT); Gasdermin-E, C-terminal (GSDME-CT)]	5	UniProt NCBI
RANBP6	Ran-binding protein 6 (RanBP6)	3	UniProt NCBI
TNPO3	Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR)	5	UniProt NCBI
FAM114A2	Protein FAM114A2	4	UniProt NCBI
GBF1	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1)	5	UniProt NCBI
BTAF1	TATA-binding protein-associated factor 172 (EC 3.6.4.-) (ATP-dependent helicase BTAF1) (B-TFIID transcription factor-associated 170 kDa subunit) (TAF(II)170) (TBP-associated factor 172) (TAF-172)	5	UniProt NCBI
SPN	Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)]	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0140142	3.2548660699e-09	0.428571428571	TNPO2 XPO4 XPO5 TNPO3 RANBP6 XPO7	nucleocytoplasmic carrier activity
GO:0140104	1.87342744182e-08	0.5	PEX19 TNPO2 XPO4 XPO5 TNPO3 RANBP6 XPO7	molecular carrier activity
KEGG:03013	1.51174652056e-06	0.357142857143	XPO7 TNPO2 XPO4 TNPO3 XPO5	Nucleocytoplasmic transport
GO:0051649	0.00201328626738	0.714285714286	PEX19 KNTC1 TNPO2 XPO5 XPO4 GBF1 TNPO3 RANBP6 XPO7 HOOK2	establishment of localization in cell
GO:0006913	0.00260339897536	0.428571428571	TNPO2 XPO4 XPO5 TNPO3 RANBP6 XPO7	nucleocytoplasmic transport
GO:0051169	0.00260339897536	0.428571428571	TNPO2 XPO4 XPO5 TNPO3 RANBP6 XPO7	nuclear transport
GO:0046907	0.00457145021632	0.642857142857	PEX19 HOOK2 TNPO2 XPO5 XPO4 GBF1 TNPO3 RANBP6 XPO7	intracellular transport
GO:0005049	0.00574694403184	0.214285714286	XPO7 XPO4 XPO5	nuclear export signal receptor activity
GO:0006886	0.00595184011417	0.5	PEX19 TNPO2 XPO4 XPO5 TNPO3 RANBP6 XPO7	intracellular protein transport
GO:0008104	0.010813658332	0.714285714286	PEX19 KNTC1 TNPO2 XPO5 XPO4 GBF1 TNPO3 RANBP6 XPO7 HOOK2	protein localization
GO:0070727	0.0110668467805	0.714285714286	PEX19 KNTC1 TNPO2 XPO5 XPO4 GBF1 TNPO3 RANBP6 XPO7 HOOK2	cellular macromolecule localization
GO:0061608	0.0194497700986	0.214285714286	TNPO2 TNPO3 RANBP6	nuclear import signal receptor activity

Edges

Protein 1	Protein 2	Score	ProteomeHD
BTNL9	PEX19	0.994
BTNL9	GSDME	0.992
BTAF1	BTNL9	0.991
XPO4	XPO7	0.988	0.52
XPO4	PEX19	0.986	0.166
PEX19	RANBP6	0.983	0.028
BTNL9	TNPO3	0.978
XPO4	HOOK2	0.976
FAM114A2	KNTC1	0.976	0.028
XPO4	SPN	0.975	0.094
XPO4	KNTC1	0.974	0.148333333333
KNTC1	TNPO2	0.974	0.054
HOOK2	BTNL9	0.973
BTNL9	TNPO2	0.973
XPO4	BTNL9	0.972
FAM114A2	XPO4	0.971	0.058
XPO4	GBF1	0.97	0.152
SPN	PEX19	0.969	0.034
BTNL9	XPO7	0.968
XPO4	GSDME	0.968	0.034
XPO5	XPO4	0.963	0.254
KNTC1	XPO7	0.963	0.176
BTAF1	RANBP6	0.962	0.074
PEX19	TNPO2	0.962	0.052
XPO4	TNPO2	0.962	0.06
BTAF1	KNTC1	0.961	0.094
PEX19	GBF1	0.961	0.13
KNTC1	GSDME	0.961	0.114
TNPO2	GSDME	0.961	0.05
XPO4	RANBP6	0.958	0.038
SPN	TNPO2	0.956	0.07
BTAF1	XPO4	0.954	0.198
GBF1	TNPO2	0.954	0.098
HOOK2	PEX19	0.947
GBF1	GSDME	0.945	0.078
BTAF1	GBF1	0.941	0.354
BTAF1	TNPO2	0.935	0.09
XPO7	TNPO3	0.932	0.21
TNPO3	GSDME	0.929	0.046
TNPO2	TNPO3	0.928	0.124
BTAF1	XPO7	0.926	0.058
PEX19	TNPO3	0.922	0.126
BTAF1	GSDME	0.921	0.094
FAM114A2	BTNL9	0.919
FAM114A2	GSDME	0.904	0.056
XPO4	TNPO3	0.9	0.134
BTAF1	PEX19	0.894	0.132
GBF1	TNPO3	0.881	0.324
HOOK2	RANBP6	0.881
XPO5	KNTC1	0.876	0.11
GBF1	XPO7	0.873	0.092
XPO5	XPO7	0.869	0.18
HOOK2	TNPO2	0.859
XPO7	TNPO2	0.847	0.348
XPO5	TNPO3	0.836	0.214
HOOK2	GBF1	0.833
BTNL9	RANBP6	0.823
SPN	GBF1	0.821	0.05
FAM114A2	PEX19	0.813	0.096
RANBP6	TNPO2	0.793	0.122
BTAF1	HOOK2	0.777
HOOK2	GSDME	0.769
KNTC1	GBF1	0.749	0.192
PEX19	GSDME	0.741	0.068
KNTC1	TNPO3	0.724	0.156
FAM114A2	TNPO2	0.706	0.042
RANBP6	TNPO3	0.692	0.072
FAM114A2	TNPO3	0.69	0.064
XPO7	GSDME	0.671	0.022
HOOK2	KNTC1	0.666
XPO5	GBF1	0.665	0.176
BTAF1	XPO5	0.651	0.224
FAM114A2	XPO7	0.636	0.05
BTAF1	TNPO3	0.621	0.102
HOOK2	XPO7	0.562
RANBP6	GSDME	0.56	0.036
XPO5	TNPO2	0.544	0.102
FAM114A2	BTAF1	0.531	0.05
FAM114A2	HOOK2	0.513
KNTC1	RANBP6	0.437	0.032
KNTC1	BTNL9	0.4
GBF1	RANBP6	0.337	0.084
HOOK2	TNPO3	0.329
XPO7	RANBP6	0.321	0.094
PEX19	XPO7	0.289	0.06
KNTC1	PEX19	0.25	0.072
FAM114A2	GBF1	0.217	0.114
XPO5	BTNL9	0.133
XPO5	GSDME	0.13	0.024
FAM114A2	RANBP6	0.125	0.038
XPO5	PEX19	0.124	0.094
XPO5	HOOK2	0.118
BTNL9	GBF1	0.073
XPO5	RANBP6	0.032	0.044
FAM114A2	XPO5	0.028	0.05
XPO5	SPN	0.027	0.046
SPN	RANBP6	0.024	0.046
BTAF1	SPN	0.022	0.106

Related Complexes

Genename	Complexes
HOOK2	huMAP3_02351.1 huMAP3_03807.1 huMAP3_06077.1 huMAP3_08298.1 huMAP3_08927.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_09132.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11065.1 huMAP3_11232.1
XPO4	huMAP3_02351.1 huMAP3_03807.1 huMAP3_05832.1 huMAP3_06077.1 huMAP3_08298.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1
TNPO2	huMAP3_05832.1 huMAP3_06077.1 huMAP3_08177.1 huMAP3_09053.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1
PEX19	huMAP3_03078.1 huMAP3_03358.1 huMAP3_03744.1 huMAP3_06077.1 huMAP3_06590.1 huMAP3_07862.1 huMAP3_08424.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1
KNTC1	huMAP3_02351.1 huMAP3_03807.1 huMAP3_06077.1 huMAP3_08298.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1 huMAP3_13274.1
BTNL9	huMAP3_02479.1 huMAP3_03148.1 huMAP3_05984.1 huMAP3_06077.1 huMAP3_08288.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10858.1 huMAP3_11232.1
XPO5	huMAP3_01355.1 huMAP3_01859.1 huMAP3_04713.1 huMAP3_05832.1 huMAP3_06077.1 huMAP3_07395.1 huMAP3_08298.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1
XPO7	huMAP3_03807.1 huMAP3_05750.1 huMAP3_05832.1 huMAP3_06077.1 huMAP3_08298.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1 huMAP3_12744.1
GSDME	huMAP3_06077.1 huMAP3_08298.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1 huMAP3_13274.1
RANBP6	huMAP3_03807.1 huMAP3_04469.1 huMAP3_06077.1 huMAP3_07201.1 huMAP3_08298.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10911.1 huMAP3_11232.1
TNPO3	huMAP3_05832.1 huMAP3_06077.1 huMAP3_08298.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1
FAM114A2	huMAP3_01094.1 huMAP3_03807.1 huMAP3_05623.1 huMAP3_06077.1 huMAP3_08298.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_10287.1 huMAP3_10448.1 huMAP3_11232.1
GBF1	huMAP3_03078.1 huMAP3_05665.1 huMAP3_06077.1 huMAP3_06788.1 huMAP3_08298.1 huMAP3_08301.1 huMAP3_09114.1 huMAP3_09399.1 huMAP3_10036.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1
BTAF1	huMAP3_01352.1 huMAP3_06077.1 huMAP3_07539.1 huMAP3_08298.1 huMAP3_08847.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_09862.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11067.1 huMAP3_11232.1
SPN	huMAP3_02351.1 huMAP3_02659.1 huMAP3_03078.1 huMAP3_06077.1 huMAP3_08298.1 huMAP3_08370.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_09338.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06077.1

Complex Portal: CPX-10880