hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06081.1

Complex Portal: CPX-11908

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
NCBP1	Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit)	5	UniProt NCBI
RALY	RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog)	5	UniProt NCBI
SRSF7	Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)	5	UniProt NCBI
HNRNPC	Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2)	5	UniProt NCBI
SRRT	Serrate RNA effector molecule homolog (Arsenite-resistance protein 2)	5	UniProt NCBI
RBBP6	E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis)	5	UniProt NCBI
TRA2A	Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A)	5	UniProt NCBI
SRSF10	Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)	5	UniProt NCBI
CLK1	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)	5	UniProt NCBI
YTHDC1	YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B)	5	UniProt NCBI
SRSF8	Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)	5	UniProt NCBI
MKRN1	E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1)	5	UniProt NCBI
PAIP2B	Polyadenylate-binding protein-interacting protein 2B (PABP-interacting protein 2B) (PAIP-2B) (Poly(A)-binding protein-interacting protein 2B)	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:03040	3.24263017368e-08	0.461538461538	SRSF8 SRSF7 TRA2A NCBP1 SRSF10 HNRNPC	Spliceosome
GO:0008380	1.15027946668e-07	0.692307692308	CLK1 SRSF8 SRSF10 TRA2A NCBP1 RALY YTHDC1 SRSF7 HNRNPC	RNA splicing
GO:0000377	6.44968893562e-07	0.615384615385	SRSF8 SRSF10 TRA2A NCBP1 RALY YTHDC1 SRSF7 HNRNPC	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000398	6.44968893562e-07	0.615384615385	SRSF8 SRSF10 TRA2A NCBP1 RALY YTHDC1 SRSF7 HNRNPC	mRNA splicing, via spliceosome
GO:0000375	7.27024868359e-07	0.615384615385	SRSF8 SRSF10 TRA2A NCBP1 RALY YTHDC1 SRSF7 HNRNPC	RNA splicing, via transesterification reactions
GO:0006396	1.85434597893e-06	0.769230769231	CLK1 SRRT SRSF8 SRSF7 TRA2A NCBP1 RALY YTHDC1 SRSF10 HNRNPC	RNA processing
REAC:R-HSA-72163	2.71764559734e-06	0.461538461538	SRSF8 SRRT SRSF7 NCBP1 SRSF10 HNRNPC	mRNA Splicing - Major Pathway
REAC:R-HSA-72172	3.33614987035e-06	0.461538461538	SRSF8 SRRT SRSF7 NCBP1 SRSF10 HNRNPC	mRNA Splicing
GO:0006397	4.08456997774e-06	0.615384615385	SRSF8 SRSF10 TRA2A NCBP1 RALY YTHDC1 SRSF7 HNRNPC	mRNA processing
WP:WP411	5.31998449901e-06	0.384615384615	CLK1 SRSF7 SRSF10 NCBP1 HNRNPC	mRNA processing
REAC:R-HSA-72203	1.72629232146e-05	0.461538461538	SRSF8 SRRT SRSF7 NCBP1 SRSF10 HNRNPC	Processing of Capped Intron-Containing Pre-mRNA
GO:0003723	1.95437085603e-05	0.846153846154	SRSF8 SRRT MKRN1 SRSF7 NCBP1 TRA2A RALY YTHDC1 SRSF10 HNRNPC RBBP6	RNA binding
GO:0043484	0.000108334258294	0.461538461538	CLK1 SRSF7 NCBP1 TRA2A YTHDC1 SRSF10	regulation of RNA splicing
GO:0016071	0.000220647308078	0.615384615385	SRSF8 SRSF10 TRA2A NCBP1 RALY YTHDC1 SRSF7 HNRNPC	mRNA metabolic process
GO:0048024	0.000345072856334	0.384615384615	YTHDC1 SRSF7 SRSF10 NCBP1 TRA2A	regulation of mRNA splicing, via spliceosome
GO:0050684	0.00106897234109	0.384615384615	YTHDC1 SRSF7 SRSF10 NCBP1 TRA2A	regulation of mRNA processing
GO:0003676	0.0010837611433	0.923076923077	SRSF8 SRRT MKRN1 SRSF7 NCBP1 TRA2A RALY PAIP2B YTHDC1 SRSF10 HNRNPC RBBP6	nucleic acid binding
GO:1903311	0.00140036727675	0.461538461538	SRSF7 TRA2A NCBP1 YTHDC1 SRSF10 HNRNPC	regulation of mRNA metabolic process
REAC:R-HSA-8953854	0.00363395798839	0.461538461538	SRSF8 SRRT SRSF7 NCBP1 SRSF10 HNRNPC	Metabolism of RNA
HPA:0301363	0.00533001832475	0.384615384615	YTHDC1 RALY HNRNPC SRRT SRSF7	lung; alveolar cells type I[High]
HPA:0570763	0.00542831522909	0.461538461538	SRSF8 SRRT NCBP1 RALY YTHDC1 HNRNPC	testis; pachytene spermatocytes[High]
HPA:0570782	0.00559990541878	0.538461538462	SRSF8 SRRT SRSF7 NCBP1 RALY YTHDC1 HNRNPC	testis; preleptotene spermatocytes[>=Medium]
HPA:0570793	0.00605954874231	0.461538461538	SRSF8 SRRT SRSF7 NCBP1 RALY HNRNPC	testis; round or early spermatids[High]
CORUM:351	0.0120868682889	0.230769230769	SRSF7 NCBP1 SRRT	Spliceosome
GO:0097159	0.0132706050996	0.923076923077	SRSF8 SRRT MKRN1 SRSF7 NCBP1 TRA2A RALY PAIP2B YTHDC1 SRSF10 HNRNPC RBBP6	organic cyclic compound binding
HPA:0301361	0.018218259457	0.461538461538	SRRT SRSF7 NCBP1 RALY YTHDC1 HNRNPC	lung; alveolar cells type I[>=Low]
HPA:0620223	0.020871317771	0.461538461538	SRSF8 SRRT NCBP1 RALY YTHDC1 HNRNPC	vagina; squamous epithelial cells[High]
HPA:0570792	0.0216590513977	0.538461538462	SRSF8 SRRT SRSF7 NCBP1 RALY YTHDC1 HNRNPC	testis; round or early spermatids[>=Medium]
HPA:0570812	0.0235247451851	0.615384615385	CLK1 SRRT SRSF8 SRSF7 NCBP1 RALY YTHDC1 HNRNPC	testis; spermatogonia cells[>=Medium]
HPA:0570783	0.023903892457	0.384615384615	SRSF8 RALY SRRT NCBP1 HNRNPC	testis; preleptotene spermatocytes[High]
HPA:0570781	0.026312492515	0.538461538462	SRSF8 SRRT SRSF7 NCBP1 RALY YTHDC1 HNRNPC	testis; preleptotene spermatocytes[>=Low]
HPA:0100122	0.0457029796537	0.615384615385	CLK1 SRRT SRSF8 SRSF7 NCBP1 RALY YTHDC1 HNRNPC	cerebral cortex; glial cells[>=Medium]
REAC:R-HSA-9013422	0.0499595654642	0.153846153846	HNRNPC RBBP6	RHOBTB1 GTPase cycle

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
TRA2A	SRSF7	0.999	0.78	mutually_exclusive (O00422)
SRSF10	SRSF7	0.997
TRA2A	SRSF10	0.997		mutually_exclusive (O00422)
HNRNPC	RALY	0.997	0.196
HNRNPC	PAIP2B	0.997
RBBP6	YTHDC1	0.997	0.254
SRRT	YTHDC1	0.996	0.324
TRA2A	NCBP1	0.996	0.18
NCBP1	PAIP2B	0.996
SRRT	NCBP1	0.996	0.65
SRRT	RBBP6	0.994	0.398
TRA2A	MKRN1	0.993	0.068
CLK1	SRSF7	0.993	0.354
MKRN1	PAIP2B	0.992
TRA2A	CLK1	0.992	0.128
NCBP1	YTHDC1	0.989	0.118
PAIP2B	SRSF7	0.988
RBBP6	SRSF7	0.987	0.358
SRSF10	RALY	0.987		mutually_exclusive (P61326)
SRSF10	YTHDC1	0.987
SRRT	SRSF10	0.984		mutually_exclusive (P52298)
HNRNPC	SRSF7	0.984	0.768
TRA2A	YTHDC1	0.983	0.408
RBBP6	CLK1	0.981	0.138
RALY	SRSF7	0.981	0.434	mutually_exclusive (P61326)
NCBP1	HNRNPC	0.98	0.883951219512
TRA2A	SRSF8	0.979	0.518	mutually_exclusive (O00422)
SRSF10	MKRN1	0.978
NCBP1	RALY	0.977	0.092
RALY	PAIP2B	0.977
SRSF8	RALY	0.976	0.178	mutually_exclusive (P61326)
MKRN1	HNRNPC	0.975	0.2115
SRSF10	PAIP2B	0.975
TRA2A	HNRNPC	0.975	0.724
SRSF8	CLK1	0.974	0.076
NCBP1	SRSF7	0.974	0.368
TRA2A	PAIP2B	0.97
HNRNPC	YTHDC1	0.969	0.324
TRA2A	SRRT	0.969	0.606
TRA2A	RBBP6	0.967	0.122
TRA2A	RALY	0.966	0.216
SRSF8	SRSF7	0.959	0.33775
SRSF8	RBBP6	0.957	0.288
NCBP1	MKRN1	0.951	0.13
CLK1	YTHDC1	0.946	0.134
SRRT	CLK1	0.943	0.234
MKRN1	RALY	0.941	0.122
NCBP1	RBBP6	0.938	0.414
SRSF10	NCBP1	0.935
SRSF10	CLK1	0.935
SRSF8	YTHDC1	0.934	0.17
SRSF10	HNRNPC	0.927
MKRN1	SRSF7	0.927	0.158
YTHDC1	SRSF7	0.923	0.494
MKRN1	SRSF8	0.92	0.112
RALY	YTHDC1	0.918	0.094
SRRT	SRSF8	0.917	0.236
PAIP2B	YTHDC1	0.914
SRSF8	HNRNPC	0.911	0.104457142857
SRRT	SRSF7	0.904	0.772
SRSF10	RBBP6	0.899
CLK1	RALY	0.897	0.194
HNRNPC	RBBP6	0.88	0.464
NCBP1	SRSF8	0.875	0.7008
SRSF8	PAIP2B	0.863
SRRT	HNRNPC	0.853	0.744
SRSF10	SRSF8	0.779
NCBP1	CLK1	0.707	0.41
MKRN1	YTHDC1	0.693	0.084
SRRT	RALY	0.673	0.35
RBBP6	RALY	0.55	0.052
HNRNPC	CLK1	0.49	0.132
SRRT	MKRN1	0.468	0.134
SRRT	PAIP2B	0.419
MKRN1	RBBP6	0.317	0.06
MKRN1	CLK1	0.208	0.092
RBBP6	PAIP2B	0.138

Related Complexes

Genename	Complexes
NCBP1	huMAP3_00714.1 huMAP3_03195.1 huMAP3_03962.1 huMAP3_05745.1 huMAP3_05874.1 huMAP3_06081.1 huMAP3_06391.1 huMAP3_06975.1 huMAP3_07267.1 huMAP3_07661.1 huMAP3_07724.1 huMAP3_07910.1 huMAP3_07973.1 huMAP3_08614.1 huMAP3_09490.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_10114.1 huMAP3_10564.1 huMAP3_11047.1 huMAP3_11073.1
RALY	huMAP3_04705.1 huMAP3_05931.1 huMAP3_06081.1 huMAP3_06093.1 huMAP3_06671.1 huMAP3_07115.1 huMAP3_07225.1 huMAP3_07581.1 huMAP3_08027.1 huMAP3_09223.1 huMAP3_09556.1 huMAP3_09654.1 huMAP3_10625.1 huMAP3_10659.1 huMAP3_11073.1
SRSF7	huMAP3_06081.1 huMAP3_06097.1 huMAP3_06391.1 huMAP3_07267.1 huMAP3_08467.1 huMAP3_08486.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_11073.1
HNRNPC	huMAP3_03195.1 huMAP3_04555.1 huMAP3_05586.1 huMAP3_06006.1 huMAP3_06081.1 huMAP3_06975.1 huMAP3_07115.1 huMAP3_07671.1 huMAP3_08038.1 huMAP3_10625.1
SRRT	huMAP3_00299.1 huMAP3_05378.1 huMAP3_06081.1 huMAP3_06391.1 huMAP3_07267.1 huMAP3_08044.1 huMAP3_08566.1 huMAP3_09490.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_11073.1
RBBP6	huMAP3_03369.1 huMAP3_05341.1 huMAP3_06081.1 huMAP3_06391.1 huMAP3_07155.1 huMAP3_08044.1 huMAP3_08467.1 huMAP3_09279.1 huMAP3_09490.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09636.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_11073.1
TRA2A	huMAP3_00197.1 huMAP3_02367.1 huMAP3_03452.1 huMAP3_04705.1 huMAP3_05807.1 huMAP3_06081.1 huMAP3_06391.1 huMAP3_06589.1 huMAP3_07267.1 huMAP3_07910.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_10564.1 huMAP3_11073.1
SRSF10	huMAP3_00489.1 huMAP3_04780.1 huMAP3_06081.1 huMAP3_06097.1 huMAP3_06391.1 huMAP3_07267.1 huMAP3_07848.1 huMAP3_08467.1 huMAP3_08486.1 huMAP3_09532.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_11073.1
CLK1	huMAP3_03369.1 huMAP3_04705.1 huMAP3_05341.1 huMAP3_06081.1 huMAP3_06846.1 huMAP3_07724.1 huMAP3_08467.1 huMAP3_08486.1 huMAP3_09279.1 huMAP3_09490.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09943.1 huMAP3_11073.1
YTHDC1	huMAP3_05378.1 huMAP3_06081.1 huMAP3_06523.1 huMAP3_06975.1 huMAP3_07291.1 huMAP3_07724.1 huMAP3_08486.1 huMAP3_08824.1 huMAP3_09490.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_10564.1 huMAP3_11073.1
SRSF8	huMAP3_02311.1 huMAP3_06081.1 huMAP3_06846.1 huMAP3_07910.1 huMAP3_08087.1 huMAP3_08486.1 huMAP3_09279.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09636.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_11073.1
MKRN1	huMAP3_00714.1 huMAP3_03962.1 huMAP3_05745.1 huMAP3_05874.1 huMAP3_06081.1 huMAP3_06391.1 huMAP3_06975.1 huMAP3_07267.1 huMAP3_07661.1 huMAP3_07973.1 huMAP3_08087.1 huMAP3_08105.1 huMAP3_08467.1 huMAP3_08486.1 huMAP3_09186.1 huMAP3_09532.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_10114.1 huMAP3_10564.1 huMAP3_11047.1 huMAP3_11073.1
PAIP2B	huMAP3_05104.1 huMAP3_05745.1 huMAP3_06081.1 huMAP3_06196.1 huMAP3_06975.1 huMAP3_07115.1 huMAP3_09362.1 huMAP3_09376.1 huMAP3_09786.1 huMAP3_10114.1 huMAP3_10625.1 huMAP3_11032.1 huMAP3_11073.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06081.1

Complex Portal: CPX-11908