hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06084.1
Complex Portal: CPX-14808
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RABGGTB | Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta) | 5 | UniProt NCBI |
| RABGGTA | Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha) | 5 | UniProt NCBI |
| RAB17 | Ras-related protein Rab-17 | 5 | UniProt NCBI |
| CHM | Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein) | 5 | UniProt NCBI |
| RAB7B | Ras-related protein Rab-7b | 5 | UniProt NCBI |
| CHML | Rab proteins geranylgeranyltransferase component A 2 (Choroideremia-like protein) (Rab escort protein 2) (REP-2) | 5 | UniProt NCBI |
| RAB9B | Ras-related protein Rab-9B (Rab-9-like protein) (Rab-9L) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8873719 | 8.35760052252e-13 | 1.0 | RABGGTA RABGGTB CHM RAB7B RAB9B RAB17 | RAB geranylgeranylation |
| GO:0004663 | 1.92240082153e-06 | 0.5 | RABGGTB RABGGTA CHM | Rab geranylgeranyltransferase activity |
| REAC:R-HSA-6803205 | 2.01823692347e-06 | 0.5 | RABGGTB RABGGTA CHM | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain |
| GO:0005968 | 7.68841921772e-06 | 0.5 | RABGGTB RABGGTA CHM | Rab-protein geranylgeranyltransferase complex |
| CORUM:6956 | 1.70876175213e-05 | 0.333333333333 | CHM RABGGTA | REP-RGGT-Rab complex |
| GO:0004661 | 1.92180881975e-05 | 0.5 | RABGGTB RABGGTA CHM | protein geranylgeranyltransferase activity |
| GO:0008318 | 3.84302573496e-05 | 0.5 | RABGGTB RABGGTA CHM | protein prenyltransferase activity |
| REAC:R-HSA-5633008 | 5.93019629716e-05 | 0.5 | RABGGTB RABGGTA CHM | TP53 Regulates Transcription of Cell Death Genes |
| REAC:R-HSA-597592 | 6.52262870964e-05 | 1.0 | RABGGTA RABGGTB CHM RAB7B RAB9B RAB17 | Post-translational protein modification |
| GO:0018344 | 6.72425931667e-05 | 0.5 | RABGGTB RABGGTA CHM | protein geranylgeranylation |
| GO:0097354 | 0.000316805542726 | 0.5 | RABGGTB RABGGTA CHM | prenylation |
| GO:0018342 | 0.000316805542726 | 0.5 | RABGGTB RABGGTA CHM | protein prenylation |
| REAC:R-HSA-392499 | 0.000464689660191 | 1.0 | RABGGTA RABGGTB CHM RAB7B RAB9B RAB17 | Metabolism of proteins |
| REAC:R-HSA-8876198 | 0.000595799814657 | 0.5 | CHM RAB7B RAB9B | RAB GEFs exchange GTP for GDP on RABs |
| GO:0004659 | 0.0010743908712 | 0.5 | RABGGTB RABGGTA CHM | prenyltransferase activity |
| REAC:R-HSA-9007101 | 0.00141970658079 | 0.5 | CHM RAB7B RAB9B | Rab regulation of trafficking |
| REAC:R-HSA-3700989 | 0.0427993747798 | 0.5 | RABGGTB RABGGTA CHM | Transcriptional Regulation by TP53 |
| GO:0016765 | 0.0446883661999 | 0.5 | RABGGTB RABGGTA CHM | transferase activity, transferring alkyl or aryl (other than methyl) groups |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RABGGTB | RABGGTA | 1.0 | 0.182 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction |
| RABGGTA | RAB7B | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RABGGTB | RAB7B | 0.996 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RABGGTA | RAB9B | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RABGGTA | CHML | 0.995 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RABGGTB | CHML | 0.995 | 0.076 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RABGGTA | CHM | 0.994 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CHM | CHML | 0.991 | 0.116 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| RABGGTB | CHM | 0.988 | 0.136 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAB7B | CHML | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RAB7B | CHM | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CHM | RAB9B | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RAB17 | CHM | 0.955 | 0.162 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RAB17 | CHML | 0.95 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RABGGTB | RAB9B | 0.775 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CHML | RAB9B | 0.685 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RAB17 | RABGGTB | 0.344 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes