hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06085.1
Complex Portal: CPX-17118
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF4A1 | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | 5 | UniProt NCBI |
| EIF4G1 | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | 5 | UniProt NCBI |
| EIF4A2 | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | 5 | UniProt NCBI |
| EIF4G3 | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | 5 | UniProt NCBI |
| IBA57 | Putative transferase CAF17, mitochondrial (EC 2.1.-.-) (Iron-sulfur cluster assembly factor homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4566 | 1.67040316852e-08 | 0.8 | EIF4A2 EIF4A1 EIF4G3 EIF4G1 | Translation inhibitors in chronically activated PDGFRA cells |
| WP:WP107 | 3.49326554308e-08 | 0.8 | EIF4A2 EIF4A1 EIF4G3 EIF4G1 | Translation factors |
| GO:0016281 | 9.40213012535e-08 | 0.8 | EIF4A2 EIF4A1 EIF4G3 EIF4G1 | eukaryotic translation initiation factor 4F complex |
| GO:0034518 | 2.39287617466e-07 | 0.8 | EIF4A2 EIF4A1 EIF4G3 EIF4G1 | RNA cap binding complex |
| REAC:R-HSA-1169408 | 3.06812697185e-07 | 0.8 | EIF4A2 EIF4A1 EIF4G3 EIF4G1 | ISG15 antiviral mechanism |
| REAC:R-HSA-1169410 | 4.37814665439e-07 | 0.8 | EIF4A2 EIF4A1 EIF4G3 EIF4G1 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-429947 | 6.30285051125e-06 | 0.6 | EIF4A2 EIF4A1 EIF4G1 | Deadenylation of mRNA |
| REAC:R-HSA-913531 | 1.59752917105e-05 | 0.8 | EIF4A2 EIF4A1 EIF4G3 EIF4G1 | Interferon Signaling |
| GO:0003743 | 1.78207144985e-05 | 0.8 | EIF4A2 EIF4A1 EIF4G3 EIF4G1 | translation initiation factor activity |
| REAC:R-HSA-429914 | 8.14372399533e-05 | 0.6 | EIF4A2 EIF4A1 EIF4G1 | Deadenylation-dependent mRNA decay |
| CORUM:5253 | 8.18785830799e-05 | 0.4 | EIF4A1 EIF4G1 | MNK1-eIF4F complex |
| REAC:R-HSA-72649 | 0.000100871107769 | 0.6 | EIF4A2 EIF4A1 EIF4G1 | Translation initiation complex formation |
| REAC:R-HSA-72702 | 0.000100871107769 | 0.6 | EIF4A2 EIF4A1 EIF4G1 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72662 | 0.000106169184171 | 0.6 | EIF4A2 EIF4A1 EIF4G1 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| GO:0008135 | 0.000120193677971 | 0.8 | EIF4A2 EIF4A1 EIF4G3 EIF4G1 | translation factor activity, RNA binding |
| GO:0090079 | 0.000265205672168 | 0.8 | EIF4A2 EIF4A1 EIF4G3 EIF4G1 | translation regulator activity, nucleic acid binding |
| GO:0006413 | 0.000625424261446 | 0.8 | EIF4A2 EIF4A1 EIF4G3 EIF4G1 | translational initiation |
| REAC:R-HSA-156827 | 0.000666150226357 | 0.6 | EIF4A2 EIF4A1 EIF4G1 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-72706 | 0.00068458375391 | 0.6 | EIF4A2 EIF4A1 EIF4G1 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| GO:0045182 | 0.000755130188848 | 0.8 | EIF4A2 EIF4A1 EIF4G3 EIF4G1 | translation regulator activity |
| REAC:R-HSA-72613 | 0.000823183245594 | 0.6 | EIF4A2 EIF4A1 EIF4G1 | Eukaryotic Translation Initiation |
| REAC:R-HSA-72737 | 0.000823183245594 | 0.6 | EIF4A2 EIF4A1 EIF4G1 | Cap-dependent Translation Initiation |
| REAC:R-HSA-1280215 | 0.00234382138907 | 0.8 | EIF4A2 EIF4A1 EIF4G3 EIF4G1 | Cytokine Signaling in Immune system |
| KEGG:05416 | 0.00645863473927 | 0.4 | EIF4G1 EIF4G3 | Viral myocarditis |
| GO:0002183 | 0.00744248347584 | 0.6 | EIF4A2 EIF4A1 EIF4G1 | cytoplasmic translational initiation |
| REAC:R-HSA-72766 | 0.0119387407373 | 0.6 | EIF4A2 EIF4A1 EIF4G1 | Translation |
| WP:WP4549 | 0.0347437372246 | 0.4 | EIF4A1 EIF4G1 | Fragile X syndrome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EIF4A1 | EIF4A2 | 0.997 | 0.392 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction treiber_WMM | |
| EIF4G1 | EIF4A1 | 0.993 |
structurally_consistent (dimer)
|
hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM | |
| EIF4A1 | EIF4G3 | 0.986 | 0.152 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| EIF4A1 | IBA57 | 0.974 | 0.038 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| EIF4G1 | EIF4A2 | 0.934 |
structurally_consistent (dimer)
|
youn () bioplex_WMM bioplex3_WMM fraction treiber_WMM | |
| EIF4G1 | EIF4G3 | 0.786 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | ||
| EIF4A2 | EIF4G3 | 0.773 | 0.068 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| EIF4G3 | IBA57 | 0.119 | 0.024 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| EIF4A2 | IBA57 | 0.105 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| EIF4G1 | IBA57 | 0.081 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes