hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06098.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MYL12B | Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1) | 5 | UniProt NCBI |
| MYL3 | Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb) | 5 | UniProt NCBI |
| MYL6 | Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) | 5 | UniProt NCBI |
| IQGAP1 | Ras GTPase-activating-like protein IQGAP1 (p195) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04814 | 0.000236813619879 | 0.75 | MYL6 MYL12B MYL3 | Motor proteins |
| REAC:R-HSA-397014 | 0.000767754055333 | 0.75 | MYL6 MYL12B MYL3 | Muscle contraction |
| REAC:R-HSA-416572 | 0.00175047124894 | 0.5 | MYL6 MYL12B | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-5627117 | 0.00175047124894 | 0.5 | MYL6 MYL12B | RHO GTPases Activate ROCKs |
| REAC:R-HSA-5625900 | 0.00175047124894 | 0.5 | MYL6 MYL12B | RHO GTPases activate CIT |
| REAC:R-HSA-5627123 | 0.00194479046925 | 0.5 | MYL6 MYL12B | RHO GTPases activate PAKs |
| REAC:R-HSA-400685 | 0.00258893271292 | 0.5 | MYL6 MYL12B | Sema4D in semaphorin signaling |
| REAC:R-HSA-3928663 | 0.00332479301982 | 0.5 | MYL6 MYL12B | EPHA-mediated growth cone collapse |
| REAC:R-HSA-195258 | 0.00591360366085 | 0.75 | MYL6 MYL12B IQGAP1 | RHO GTPase Effectors |
| REAC:R-HSA-445355 | 0.0068064250699 | 0.5 | MYL6 MYL12B | Smooth Muscle Contraction |
| KEGG:04520 | 0.00909742323246 | 0.5 | IQGAP1 MYL12B | Adherens junction |
| REAC:R-HSA-373755 | 0.0174510452107 | 0.5 | MYL6 MYL12B | Semaphorin interactions |
| WP:WP51 | 0.0205195911139 | 0.5 | IQGAP1 MYL3 | Regulation of actin cytoskeleton |
| GO:0015629 | 0.0215651548249 | 1.0 | MYL6 MYL12B IQGAP1 MYL3 | actin cytoskeleton |
| KEGG:04530 | 0.0237566589162 | 0.5 | MYL6 MYL12B | Tight junction |
| CORUM:6729 | 0.0249718442456 | 0.25 | IQGAP1 | IQGAP1-CXCR2 complex |
| CORUM:1844 | 0.0249718442456 | 0.25 | IQGAP1 | APC-IQGAP1 complex |
| REAC:R-HSA-5625740 | 0.0329793636325 | 0.5 | MYL6 MYL12B | RHO GTPases activate PKNs |
| REAC:R-HSA-2682334 | 0.0338007536087 | 0.5 | MYL6 MYL12B | EPH-Ephrin signaling |
| KEGG:04810 | 0.0466115978004 | 0.5 | IQGAP1 MYL12B | Regulation of actin cytoskeleton |
| CORUM:1845 | 0.049938562206 | 0.25 | IQGAP1 | APC-IQGAP1-CLIP-170 complex |
| CORUM:3008 | 0.049938562206 | 0.25 | IQGAP1 | 60S APC containing complex |
| CORUM:3011 | 0.049938562206 | 0.25 | IQGAP1 | APC-IQGAP1-Rac1 complex |
| CORUM:3012 | 0.049938562206 | 0.25 | IQGAP1 | APC-IQGAP1-Cdc42 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MYL6 | MYL12B | 0.993 | 0.146 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| MYL3 | IQGAP1 | 0.992 | 0.174 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| MYL6 | IQGAP1 | 0.991 | 0.252624 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| MYL12B | IQGAP1 | 0.984 | 0.544 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
| MYL6 | MYL3 | 0.975 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MYL12B | MYL3 | 0.869 | 0.676 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes