hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06102.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRRG1 | Transmembrane gamma-carboxyglutamic acid protein 1 (Proline-rich gamma-carboxyglutamic acid protein 1) (Proline-rich Gla protein 1) | 4 | UniProt NCBI |
| ARRDC1 | Arrestin domain-containing protein 1 (Alpha-arrestin 1) | 5 | UniProt NCBI |
| HECW1 | E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) | 5 | UniProt NCBI |
| HECW2 | E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2) | 5 | UniProt NCBI |
| NDFIP2 | NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413) | 5 | UniProt NCBI |
| ILDR1 | Immunoglobulin-like domain-containing receptor 1 (Angulin-2) | 5 | UniProt NCBI |
| FAIM2 | Protein lifeguard 2 (Fas apoptotic inhibitory molecule 2) (Neural membrane protein 35) (Transmembrane BAX inhibitor motif-containing protein 2) | 5 | UniProt NCBI |
| NEDD4 | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) | 5 | UniProt NCBI |
| ITCH | E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1253288 | 0.00223242997382 | 0.222222222222 | NEDD4 ITCH | Downregulation of ERBB4 signaling |
| GO:0016567 | 0.00730404922177 | 0.666666666667 | NEDD4 ARRDC1 HECW1 HECW2 ITCH NDFIP2 | protein ubiquitination |
| GO:0032446 | 0.0156608922208 | 0.666666666667 | NEDD4 ARRDC1 HECW1 HECW2 ITCH NDFIP2 | protein modification by small protein conjugation |
| GO:0070647 | 0.0280697756258 | 0.666666666667 | NEDD4 ARRDC1 HECW1 HECW2 ITCH NDFIP2 | protein modification by small protein conjugation or removal |
| GO:0048814 | 0.0396911574974 | 0.333333333333 | HECW2 HECW1 NEDD4 | regulation of dendrite morphogenesis |
| GO:0043687 | 0.0413349003112 | 0.666666666667 | NEDD4 ARRDC1 HECW1 HECW2 ITCH NDFIP2 | post-translational protein modification |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NEDD4 | ILDR1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ILDR1 | HECW2 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HECW1 | ILDR1 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NEDD4 | PRRG1 | 0.992 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NDFIP2 | ITCH | 0.991 | 0.064 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| HECW1 | PRRG1 | 0.99 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PRRG1 | HECW2 | 0.99 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NEDD4 | NDFIP2 | 0.989 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ARRDC1 | ITCH | 0.989 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NEDD4 | HECW2 | 0.985 | bioplex_WMM bioplex3_WMM WMM_only | |
| NEDD4 | ARRDC1 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NEDD4 | FAIM2 | 0.98 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HECW1 | HECW2 | 0.964 | 0.202 | bioplex_WMM bioplex3_WMM WMM_only |
| NEDD4 | HECW1 | 0.953 | bioplex_WMM bioplex3_WMM WMM_only | |
| NEDD4 | ITCH | 0.952 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| ILDR1 | ITCH | 0.95 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HECW2 | ITCH | 0.941 | 0.19 | bioplex_WMM bioplex3_WMM WMM_only |
| HECW1 | ITCH | 0.913 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only |
| ARRDC1 | HECW2 | 0.291 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PRRG1 | ITCH | 0.131 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ARRDC1 | PRRG1 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | |
| HECW2 | NDFIP2 | 0.106 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only |
| ARRDC1 | NDFIP2 | 0.079 | 0.13 | bioplex3_WMM WMM_only |
| PRRG1 | NDFIP2 | 0.067 | bioplex3_WMM WMM_only | |
| FAIM2 | ITCH | 0.012 | bioplex3_HCT116 WMM_only |
Related Complexes