hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06113.1
Complex Portal: CPX-20024
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KCNA10 | Potassium voltage-gated channel subfamily A member 10 (Voltage-gated potassium channel subunit Kv1.8) | 5 | UniProt NCBI |
| CAV3 | Caveolin-3 (M-caveolin) | 5 | UniProt NCBI |
| REEP1 | Receptor expression-enhancing protein 1 (Spastic paraplegia 31 protein) | 5 | UniProt NCBI |
| REEP2 | Receptor expression-enhancing protein 2 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001761 | 0.0123391078674 | 0.75 | REEP2 CAV3 REEP1 | Pes cavus |
| HP:0030237 | 0.0273256954732 | 0.5 | CAV3 REEP1 | Hand muscle weakness |
| HP:0009130 | 0.03008608933 | 0.5 | CAV3 REEP1 | Hand muscle atrophy |
| HP:0003474 | 0.0326734499101 | 0.75 | REEP2 CAV3 REEP1 | Somatic sensory dysfunction |
| HP:0007149 | 0.0424493051949 | 0.5 | CAV3 REEP1 | Distal upper limb amyotrophy |
| CORUM:422 | 0.049938562206 | 0.25 | CAV3 | Beta-dystroglycan-caveolin-3 complex |
| CORUM:6430 | 0.049938562206 | 0.25 | REEP1 | ATL2-SPG31 complex |
| CORUM:6431 | 0.049938562206 | 0.25 | REEP1 | ATL3-SPG31 complex |
| CORUM:6534 | 0.049938562206 | 0.25 | REEP1 | SPG31-SPG33 omplex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CAV3 | REEP2 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| REEP1 | CAV3 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KCNA10 | REEP1 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| REEP1 | REEP2 | 0.984 | 0.12 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes