hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06121.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CCNB3 | G2/mitotic-specific cyclin-B3 | 5 | UniProt NCBI |
| CCND1 | G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) | 5 | UniProt NCBI |
| CCND3 | G1/S-specific cyclin-D3 | 5 | UniProt NCBI |
| CCND2 | G1/S-specific cyclin-D2 | 5 | UniProt NCBI |
| CCNO | Cyclin-O | 5 | UniProt NCBI |
| FGR | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | 5 | UniProt NCBI |
| CDKN1A | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1634 | 1.36501667663e-05 | 0.4 | CCND1 CDKN1A | CyclinD1-CDK4-p21 complex |
| CORUM:312 | 1.36501667663e-05 | 0.4 | CCND1 CDKN1A | Cell cycle kinase complex CDK4 |
| CORUM:311 | 1.36501667663e-05 | 0.4 | CCND1 CDKN1A | Cell cycle kinase complex CDK2 |
| GO:0016538 | 1.46952249556e-05 | 0.8 | CCNB3 CDKN1A CCND1 CCNO | cyclin-dependent protein serine/threonine kinase regulator activity |
| CORUM:313 | 4.09448956317e-05 | 0.4 | CCND1 CDKN1A | Cell cycle kinase complex CDK5 |
| GO:0000307 | 4.47449753489e-05 | 0.8 | CCNB3 CDKN1A CCND1 CCNO | cyclin-dependent protein kinase holoenzyme complex |
| WP:WP1530 | 5.24101251737e-05 | 0.6 | CCNB3 CCND1 CDKN1A | miRNA regulation of DNA damage response |
| WP:WP707 | 5.24101251737e-05 | 0.6 | CCNB3 CCND1 CDKN1A | DNA damage response |
| CORUM:310 | 8.18785830799e-05 | 0.4 | CCND1 CDKN1A | Cell cycle kinase complex CDC2 |
| KEGG:04068 | 0.00021603679603 | 0.6 | CCNB3 CCND1 CDKN1A | FoxO signaling pathway |
| WP:WP179 | 0.000302523176006 | 0.6 | CCNB3 CCND1 CDKN1A | Cell cycle |
| WP:WP4790 | 0.0003876755558 | 0.4 | CCND1 CDKN1A | FGF23 signaling in hypophosphatemic rickets and related disorders |
| KEGG:04218 | 0.000411831232455 | 0.6 | CCNB3 CCND1 CDKN1A | Cellular senescence |
| KEGG:04110 | 0.000516961308947 | 0.6 | CCNB3 CCND1 CDKN1A | Cell cycle |
| WP:WP1545 | 0.000534376000489 | 0.4 | CCND1 CDKN1A | miRNAs involved in DNA damage response |
| GO:1902554 | 0.00130803575944 | 0.8 | CCNB3 CDKN1A CCND1 CCNO | serine/threonine protein kinase complex |
| HP:0008261 | 0.00179436403841 | 0.4 | CCND1 CDKN1A | Pancreatic islet cell adenoma |
| REAC:R-HSA-9661069 | 0.00206313859056 | 0.4 | CCND1 CDKN1A | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) |
| REAC:R-HSA-9659787 | 0.00206313859056 | 0.4 | CCND1 CDKN1A | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects |
| GO:1902911 | 0.00218060317198 | 0.8 | CCNB3 CDKN1A CCND1 CCNO | protein kinase complex |
| WP:WP3981 | 0.00237924603132 | 0.4 | CCND1 CDKN1A | miRNA regulation of prostate cancer signaling pathways |
| KEGG:05216 | 0.00253895212354 | 0.4 | CCND1 CDKN1A | Thyroid cancer |
| KEGG:05219 | 0.0028504483789 | 0.4 | CCND1 CDKN1A | Bladder cancer |
| WP:WP2828 | 0.00348396083589 | 0.4 | CCND1 CDKN1A | Bladder cancer |
| HP:0030405 | 0.00422725674544 | 0.4 | CCND1 CDKN1A | Pancreatic endocrine tumor |
| GO:0019887 | 0.00480818953079 | 0.8 | CCNB3 CDKN1A CCND1 CCNO | protein kinase regulator activity |
| WP:WP3646 | 0.00503666229327 | 0.4 | CCND1 CDKN1A | Hepatitis C and hepatocellular carcinoma |
| WP:WP3611 | 0.00528162918062 | 0.4 | CCND1 CDKN1A | Photodynamic therapy induced AP 1 survival signaling |
| KEGG:05213 | 0.00598637208626 | 0.4 | CCND1 CDKN1A | Endometrial cancer |
| KEGG:05218 | 0.00852542753416 | 0.4 | CCND1 CDKN1A | Melanoma |
| GO:0019207 | 0.00893796193013 | 0.8 | CCNB3 CDKN1A CCND1 CCNO | kinase regulator activity |
| REAC:R-HSA-9687139 | 0.00900400267976 | 0.4 | CCND1 CDKN1A | Aberrant regulation of mitotic cell cycle due to RB1 defects |
| KEGG:04115 | 0.00908648748607 | 0.4 | CCND1 CDKN1A | p53 signaling pathway |
| WP:WP4155 | 0.00931707261303 | 0.4 | CCND1 CDKN1A | Endometrial cancer |
| REAC:R-HSA-9675126 | 0.0100756681589 | 0.4 | CCND1 CDKN1A | Diseases of mitotic cell cycle |
| KEGG:05223 | 0.0102617382696 | 0.4 | CCND1 CDKN1A | Non-small cell lung cancer |
| KEGG:05214 | 0.0102617382696 | 0.4 | CCND1 CDKN1A | Glioma |
| WP:WP4685 | 0.010328593539 | 0.4 | CCND1 CDKN1A | Melanoma |
| KEGG:05212 | 0.0115077320087 | 0.4 | CCND1 CDKN1A | Pancreatic cancer |
| WP:WP45 | 0.0117576408425 | 0.4 | CCND1 CDKN1A | G1 to S cell cycle control |
| KEGG:05220 | 0.012157220678 | 0.4 | CCND1 CDKN1A | Chronic myeloid leukemia |
| WP:WP4216 | 0.0128896073912 | 0.4 | CCND1 CDKN1A | Chromosomal and microsatellite instability in colorectal cancer |
| WP:WP4255 | 0.0128896073912 | 0.4 | CCND1 CDKN1A | Non small cell lung cancer |
| KEGG:05210 | 0.0135091080522 | 0.4 | CCND1 CDKN1A | Colorectal cancer |
| WP:WP4674 | 0.0140730862084 | 0.4 | CCND1 CDKN1A | Head and neck squamous cell carcinoma |
| KEGG:01522 | 0.0149314441262 | 0.4 | CCND1 CDKN1A | Endocrine resistance |
| REAC:R-HSA-69236 | 0.0156388304105 | 0.4 | CCND1 CDKN1A | G1 Phase |
| REAC:R-HSA-69231 | 0.0156388304105 | 0.4 | CCND1 CDKN1A | Cyclin D associated events in G1 |
| WP:WP5098 | 0.015731077008 | 0.4 | CCND1 CDKN1A | T cell activation SARS CoV 2 |
| KEGG:05222 | 0.0164241113683 | 0.4 | CCND1 CDKN1A | Small cell lung cancer |
| WP:WP2261 | 0.017034501082 | 0.4 | CCND1 CDKN1A | Glioblastoma signaling pathways |
| KEGG:05215 | 0.0179869923441 | 0.4 | CCND1 CDKN1A | Prostate cancer |
| WP:WP4263 | 0.0188521857166 | 0.4 | CCND1 CDKN1A | Pancreatic adenocarcinoma pathway |
| WP:WP673 | 0.0188521857166 | 0.4 | CCND1 CDKN1A | ErbB signaling pathway |
| HP:0002666 | 0.0207761643339 | 0.4 | CCND1 CDKN1A | Pheochromocytoma |
| WP:WP2446 | 0.0212523049113 | 0.4 | CCND1 CDKN1A | Retinoblastoma gene in cancer |
| HP:0006476 | 0.0224351839587 | 0.4 | CCND1 CDKN1A | Abnormality of the pancreatic islet cells |
| WP:WP4658 | 0.0227605362571 | 0.4 | CCND1 CDKN1A | Small cell lung cancer |
| HP:0012093 | 0.0241576577336 | 0.4 | CCND1 CDKN1A | Abnormality of endocrine pancreas physiology |
| REAC:R-HSA-187577 | 0.0266933781073 | 0.4 | CCND1 CDKN1A | SCF(Skp2)-mediated degradation of p27/p21 |
| WP:WP710 | 0.0293032373139 | 0.4 | CCND1 CDKN1A | DNA damage response only ATM dependent |
| GO:0061695 | 0.0306592465565 | 0.8 | CCNB3 CDKN1A CCND1 CCNO | transferase complex, transferring phosphorus-containing groups |
| KEGG:04921 | 0.03088329966 | 0.4 | CCND1 CDKN1A | Oxytocin signaling pathway |
| WP:WP4659 | 0.0316649111647 | 0.4 | CCND1 CDKN1A | Gastrin signaling pathway |
| KEGG:04934 | 0.0346393491085 | 0.4 | CCND1 CDKN1A | Cushing syndrome |
| KEGG:05224 | 0.035751387428 | 0.4 | CCND1 CDKN1A | Breast cancer |
| HP:0100634 | 0.0358235710582 | 0.4 | CCND1 CDKN1A | Neuroendocrine neoplasm |
| KEGG:04630 | 0.0380272112444 | 0.4 | CCND1 CDKN1A | JAK-STAT signaling pathway |
| KEGG:05160 | 0.0380272112444 | 0.4 | CCND1 CDKN1A | Hepatitis C |
| KEGG:05226 | 0.0380272112444 | 0.4 | CCND1 CDKN1A | Gastric cancer |
| WP:WP366 | 0.0406395857275 | 0.4 | CCND1 CDKN1A | TGF beta signaling pathway |
| WP:WP2877 | 0.0462612174005 | 0.4 | CCND1 CDKN1A | Vitamin D receptor pathway |
| KEGG:05206 | 0.0484667159694 | 0.4 | CCND1 CDKN1A | MicroRNAs in cancer |
| HP:0100631 | 0.0497672375822 | 0.4 | CCND1 CDKN1A | Neoplasm of the adrenal gland |
| CORUM:314 | 0.0498708842806 | 0.2 | CDKN1A | PCNA-p21 complex |
| CORUM:5287 | 0.0498708842806 | 0.2 | CCND1 | CCND1-CDK4 complex |
| CORUM:3084 | 0.0498708842806 | 0.2 | CCND1 | CCND1-CDK4 complex |
| REAC:R-HSA-69202 | 0.0499330761364 | 0.4 | CCND1 CDKN1A | Cyclin E associated events during G1/S transition |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CDKN1A | CCND3 | 0.999 | 0.218 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CCND2 | CDKN1A | 0.999 | 0.226 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CDKN1A | CCND1 | 0.998 | 0.2396 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CCNO | CDKN1A | 0.996 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CCNB3 | CDKN1A | 0.991 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FGR | CDKN1A | 0.981 | 0.138 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| CCND1 | CCND3 | 0.95 | 0.168 | hein_WMM bioplex3_WMM WMM_only |
| CCNO | CCNB3 | 0.902 | bioplex3_WMM WMM_only | |
| CCNO | FGR | 0.869 | bioplex3_WMM WMM_only | |
| FGR | CCNB3 | 0.869 | bioplex3_WMM WMM_only | |
| CCNO | CCND3 | 0.676 | bioplex3_WMM WMM_only | |
| FGR | CCND1 | 0.634 | bioplex3_WMM WMM_only | |
| FGR | CCND3 | 0.633 | bioplex3_WMM WMM_only | |
| CCNB3 | CCND3 | 0.622 | bioplex3_WMM WMM_only | |
| CCND2 | CCND3 | 0.594 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only |
| CCNB3 | CCND1 | 0.477 | bioplex3_WMM WMM_only | |
| CCNO | CCND1 | 0.455 | bioplex3_WMM WMM_only | |
| CCND2 | CCNO | 0.214 | bioplex3_WMM WMM_only | |
| CCND2 | CCND1 | 0.175 | 0.192 | bioplex3_WMM WMM_only |
| CCND2 | CCNB3 | 0.135 | bioplex3_WMM WMM_only | |
| CCND2 | FGR | 0.046 | 0.09 | bioplex3_WMM WMM_only |
Related Complexes