hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06126.1
Complex Portal: CPX-20562
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLC15A4 | Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1) | 5 | UniProt NCBI |
| SLC12A7 | Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) | 5 | UniProt NCBI |
| LGALS9 | Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21) | 5 | UniProt NCBI |
| ATP2B4 | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | 5 | UniProt NCBI |
| ATG9A | Autophagy-related protein 9A (APG9-like 1) (mATG9) | 5 | UniProt NCBI |
| SLC4A7 | Sodium bicarbonate cotransporter 3 (Electroneutral Na/HCO(3) cotransporter) (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7) | 5 | UniProt NCBI |
| LGALS9C | Galectin-9C (Gal-9C) (Galectin-9-like protein B) | 5 | UniProt NCBI |
| SLC30A1 | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | 5 | UniProt NCBI |
| LGALS9B | Galectin-9B (Gal-9B) (Galectin-9-like protein A) | 4 | UniProt NCBI |
| CLCN3 | H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3) | 5 | UniProt NCBI |
| ABCC4 | ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016936 | 1.15344049292e-05 | 0.3 | LGALS9B LGALS9 LGALS9C | galactoside binding |
| REAC:R-HSA-382551 | 0.000102437559649 | 0.6 | SLC15A4 CLCN3 SLC30A1 SLC4A7 ABCC4 SLC12A7 | Transport of small molecules |
| GO:2000562 | 0.00040312426486 | 0.3 | LGALS9B LGALS9 LGALS9C | negative regulation of CD4-positive, alpha-beta T cell proliferation |
| GO:0022804 | 0.000405404266491 | 0.6 | SLC15A4 CLCN3 SLC30A1 SLC4A7 ABCC4 SLC12A7 | active transmembrane transporter activity |
| REAC:R-HSA-425407 | 0.000666714736577 | 0.4 | SLC30A1 SLC15A4 SLC12A7 SLC4A7 | SLC-mediated transmembrane transport |
| GO:0046642 | 0.000966803032193 | 0.3 | LGALS9B LGALS9 LGALS9C | negative regulation of alpha-beta T cell proliferation |
| GO:0015291 | 0.00101275824992 | 0.5 | SLC30A1 SLC15A4 CLCN3 SLC12A7 SLC4A7 | secondary active transmembrane transporter activity |
| GO:0035739 | 0.00138065085968 | 0.3 | LGALS9B LGALS9 LGALS9C | CD4-positive, alpha-beta T cell proliferation |
| GO:2000561 | 0.00138065085968 | 0.3 | LGALS9B LGALS9 LGALS9C | regulation of CD4-positive, alpha-beta T cell proliferation |
| REAC:R-HSA-425393 | 0.00227120807117 | 0.3 | SLC15A4 SLC12A7 SLC4A7 | Transport of inorganic cations/anions and amino acids/oligopeptides |
| GO:0015318 | 0.00448683467166 | 0.6 | SLC15A4 CLCN3 SLC30A1 SLC4A7 ABCC4 SLC12A7 | inorganic molecular entity transmembrane transporter activity |
| GO:0005215 | 0.00598661173167 | 0.7 | SLC15A4 CLCN3 SLC30A1 ABCC4 SLC4A7 ATG9A SLC12A7 | transporter activity |
| GO:2000515 | 0.0111127441894 | 0.3 | LGALS9B LGALS9 LGALS9C | negative regulation of CD4-positive, alpha-beta T cell activation |
| GO:0046633 | 0.0202810995064 | 0.3 | LGALS9B LGALS9 LGALS9C | alpha-beta T cell proliferation |
| GO:0046640 | 0.0202810995064 | 0.3 | LGALS9B LGALS9 LGALS9C | regulation of alpha-beta T cell proliferation |
| GO:0032689 | 0.0231700664584 | 0.3 | LGALS9B LGALS9 LGALS9C | negative regulation of type II interferon production |
| GO:0046636 | 0.0263201547963 | 0.3 | LGALS9B LGALS9 LGALS9C | negative regulation of alpha-beta T cell activation |
| WP:WP3945 | 0.0404201860118 | 0.2 | LGALS9C ABCC4 | TYROBP causal network in microglia |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| LGALS9 | LGALS9B | 1.0 | ||
| LGALS9 | LGALS9C | 1.0 |
mutually_exclusive (Q7Z3C6)
|
|
| LGALS9 | SLC4A7 | 0.998 | 0.182 | |
| LGALS9 | SLC12A7 | 0.998 | 0.068 | |
| ATG9A | LGALS9 | 0.998 | 0.164 |
structurally_consistent (dimer)
|
| SLC30A1 | LGALS9B | 0.996 | ||
| LGALS9C | SLC12A7 | 0.996 | ||
| LGALS9 | ATP2B4 | 0.996 | 0.29 | |
| LGALS9B | ABCC4 | 0.994 | ||
| LGALS9B | SLC12A7 | 0.993 | ||
| ATP2B4 | LGALS9C | 0.993 | ||
| LGALS9 | CLCN3 | 0.992 | 0.08 | |
| LGALS9 | ABCC4 | 0.99 | 0.236 | |
| SLC30A1 | LGALS9 | 0.985 | 0.246 | |
| LGALS9B | CLCN3 | 0.984 | ||
| ATP2B4 | LGALS9B | 0.983 | ||
| ATG9A | LGALS9B | 0.98 | ||
| SLC4A7 | LGALS9B | 0.978 | ||
| ATG9A | ATP2B4 | 0.977 | 0.120035714286 | |
| SLC15A4 | LGALS9 | 0.976 | 0.094 | |
| LGALS9C | ABCC4 | 0.97 | ||
| SLC30A1 | SLC12A7 | 0.965 | 0.074 | |
| ATP2B4 | SLC12A7 | 0.961 | 0.036 | |
| ATG9A | SLC4A7 | 0.959 | 0.11 | |
| ATG9A | SLC12A7 | 0.954 | 0.042 | |
| SLC30A1 | ABCC4 | 0.952 | 0.092 | |
| ATP2B4 | ABCC4 | 0.952 | 0.068 | |
| SLC15A4 | SLC12A7 | 0.943 | 0.078 | |
| SLC30A1 | CLCN3 | 0.941 | 0.114 | |
| CLCN3 | ABCC4 | 0.935 | 0.054 | |
| SLC12A7 | ABCC4 | 0.93 | 0.112 | |
| SLC4A7 | ABCC4 | 0.929 | 0.074 | |
| ATP2B4 | CLCN3 | 0.921 | 0.13 | |
| SLC15A4 | ATG9A | 0.92 | 0.164 | |
| ATG9A | LGALS9C | 0.915 |
structurally_consistent (dimer)
|
|
| ATP2B4 | SLC4A7 | 0.914 | 0.08 | |
| ATG9A | CLCN3 | 0.911 | 0.14 | |
| CLCN3 | SLC12A7 | 0.911 | 0.078 | |
| SLC4A7 | LGALS9C | 0.91 | ||
| SLC30A1 | ATG9A | 0.909 | 0.118 | |
| SLC15A4 | ABCC4 | 0.903 | 0.064 | |
| SLC30A1 | SLC4A7 | 0.902 | 0.112 | |
| SLC30A1 | ATP2B4 | 0.889 | 0.06 | |
| SLC4A7 | CLCN3 | 0.879 | 0.048 | |
| SLC4A7 | SLC12A7 | 0.864 | 0.076 | |
| SLC15A4 | ATP2B4 | 0.863 | 0.066 | |
| SLC15A4 | SLC4A7 | 0.832 | 0.048 | |
| ATG9A | ABCC4 | 0.829 | 0.046 | |
| SLC30A1 | SLC15A4 | 0.81 | 0.068 | |
| SLC15A4 | CLCN3 | 0.427 | 0.152 | |
| SLC15A4 | LGALS9B | 0.334 |
Related Complexes