hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06133.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UQCRC1 | Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) | 5 | UniProt NCBI |
| MT-CYB | Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit) | 5 | UniProt NCBI |
| UQCRB | Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) | 5 | UniProt NCBI |
| UQCRQ | Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4921 | 3.52698537821e-08 | 1.0 | UQCRC1 MT-CYB UQCRQ | Mitochondrial complex III assembly |
| KEGG:04260 | 3.11554307054e-06 | 1.0 | UQCRC1 MT-CYB UQCRQ | Cardiac muscle contraction |
| WP:WP111 | 1.17898981996e-05 | 1.0 | UQCRC1 MT-CYB UQCRQ | Electron transport chain OXPHOS system in mitochondria |
| KEGG:00190 | 1.54230874605e-05 | 1.0 | UQCRC1 MT-CYB UQCRQ | Oxidative phosphorylation |
| GO:0006122 | 1.58598067776e-05 | 1.0 | UQCRC1 MT-CYB UQCRQ | mitochondrial electron transport, ubiquinol to cytochrome c |
| GO:0005750 | 2.11464090368e-05 | 1.0 | UQCRC1 MT-CYB UQCRQ | mitochondrial respiratory chain complex III |
| GO:0045275 | 2.11464090368e-05 | 1.0 | UQCRC1 MT-CYB UQCRQ | respiratory chain complex III |
| KEGG:04932 | 2.28801742777e-05 | 1.0 | UQCRC1 MT-CYB UQCRQ | Non-alcoholic fatty liver disease |
| WP:WP4396 | 3.24963255001e-05 | 1.0 | UQCRC1 MT-CYB UQCRQ | Nonalcoholic fatty liver disease |
| KEGG:05415 | 5.16258651055e-05 | 1.0 | UQCRC1 MT-CYB UQCRQ | Diabetic cardiomyopathy |
| KEGG:05208 | 7.07004693439e-05 | 1.0 | UQCRC1 MT-CYB UQCRQ | Chemical carcinogenesis - reactive oxygen species |
| REAC:R-HSA-611105 | 7.31860792369e-05 | 1.0 | UQCRC1 MT-CYB UQCRQ | Respiratory electron transport |
| KEGG:04714 | 7.39136996301e-05 | 1.0 | UQCRC1 MT-CYB UQCRQ | Thermogenesis |
| KEGG:05012 | 0.00011589966492 | 1.0 | UQCRC1 MT-CYB UQCRQ | Parkinson disease |
| KEGG:05020 | 0.000126475690353 | 1.0 | UQCRC1 MT-CYB UQCRQ | Prion disease |
| REAC:R-HSA-163200 | 0.000134372084608 | 1.0 | UQCRC1 MT-CYB UQCRQ | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:05016 | 0.000171368189864 | 1.0 | UQCRC1 MT-CYB UQCRQ | Huntington disease |
| KEGG:05014 | 0.00029339200738 | 1.0 | UQCRC1 MT-CYB UQCRQ | Amyotrophic lateral sclerosis |
| KEGG:05010 | 0.000339187774081 | 1.0 | UQCRC1 MT-CYB UQCRQ | Alzheimer disease |
| GO:0070069 | 0.000351222630093 | 1.0 | UQCRC1 MT-CYB UQCRQ | cytochrome complex |
| REAC:R-HSA-1428517 | 0.000368729542429 | 1.0 | UQCRC1 MT-CYB UQCRQ | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:05022 | 0.000613327564103 | 1.0 | UQCRC1 MT-CYB UQCRQ | Pathways of neurodegeneration - multiple diseases |
| GO:0019646 | 0.00675723888767 | 1.0 | UQCRC1 MT-CYB UQCRQ | aerobic electron transport chain |
| GO:0098803 | 0.00760107672828 | 1.0 | UQCRC1 MT-CYB UQCRQ | respiratory chain complex |
| GO:0008121 | 0.00842684400117 | 0.666666666667 | UQCRC1 MT-CYB | ubiquinol-cytochrome-c reductase activity |
| GO:0042773 | 0.00851239083773 | 1.0 | UQCRC1 MT-CYB UQCRQ | ATP synthesis coupled electron transport |
| GO:0042775 | 0.00851239083773 | 1.0 | UQCRC1 MT-CYB UQCRQ | mitochondrial ATP synthesis coupled electron transport |
| GO:0070469 | 0.00949377645712 | 1.0 | UQCRC1 MT-CYB UQCRQ | respirasome |
| GO:0005746 | 0.00949377645712 | 1.0 | UQCRC1 MT-CYB UQCRQ | mitochondrial respirasome |
| GO:0022904 | 0.0116771431902 | 1.0 | UQCRC1 MT-CYB UQCRQ | respiratory electron transport chain |
| GO:0016679 | 0.0140440992017 | 0.666666666667 | UQCRC1 MT-CYB | oxidoreductase activity, acting on diphenols and related substances as donors |
| GO:0022900 | 0.0150763323228 | 1.0 | UQCRC1 MT-CYB UQCRQ | electron transport chain |
| HP:0003200 | 0.0167410266547 | 0.666666666667 | UQCRQ MT-CYB | Ragged-red muscle fibers |
| KEGG:01100 | 0.0189521995452 | 1.0 | UQCRC1 MT-CYB UQCRQ | Metabolic pathways |
| HP:0001271 | 0.0194392651505 | 0.666666666667 | UQCRC1 MT-CYB | Polyneuropathy |
| GO:1990204 | 0.0219076797621 | 1.0 | UQCRC1 MT-CYB UQCRQ | oxidoreductase complex |
| GO:0006119 | 0.025655976884 | 1.0 | UQCRC1 MT-CYB UQCRQ | oxidative phosphorylation |
| GO:0098800 | 0.0498541011049 | 1.0 | UQCRC1 MT-CYB UQCRQ | inner mitochondrial membrane protein complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| UQCRB | UQCRC1 | 0.999 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | |
| UQCRQ | UQCRC1 | 0.998 | 0.962 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| UQCRB | UQCRQ | 0.996 | 0.992 |
structurally_consistent (P22695)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| MT-CYB | UQCRQ | 0.995 | 0.77 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| MT-CYB | UQCRB | 0.981 | 0.814 |
structurally_consistent (Q9H7Z7)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MT-CYB | UQCRC1 | 0.944 | 0.762 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes