hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06135.1
Complex Portal: CPX-22117
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SH3RF3 | E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4) | 5 | UniProt NCBI |
| ZNF395 | Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) | 5 | UniProt NCBI |
| ANKRD34A | Ankyrin repeat domain-containing protein 34A | 3 | UniProt NCBI |
| AKT1S1 | Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate) | 5 | UniProt NCBI |
| YWHAG | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | 5 | UniProt NCBI |
| FOXO3 | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9614399 | 0.00170100530318 | 0.333333333333 | YWHAG FOXO3 | Regulation of localization of FOXO transcription factors |
| REAC:R-HSA-5674400 | 0.00771351163082 | 0.333333333333 | FOXO3 AKT1S1 | Constitutive Signaling by AKT1 E17K in Cancer |
| KEGG:04213 | 0.0103053165388 | 0.333333333333 | FOXO3 AKT1S1 | Longevity regulating pathway - multiple species |
| KEGG:04211 | 0.0232178892038 | 0.333333333333 | FOXO3 AKT1S1 | Longevity regulating pathway |
| KEGG:04152 | 0.045081780015 | 0.333333333333 | FOXO3 AKT1S1 | AMPK signaling pathway |
| REAC:R-HSA-9614085 | 0.0452196184553 | 0.333333333333 | YWHAG FOXO3 | FOXO-mediated transcription |
| CORUM:6730 | 0.0499436884912 | 0.166666666667 | YWHAG | 14-3-3 gamma-CXCR2 complex, unstimulated |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| YWHAG | FOXO3 | 0.991 | 0.444 | bioplex3_HEK293 bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| YWHAG | ZNF395 | 0.973 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| YWHAG | AKT1S1 | 0.971 | 0.188 | bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only | |
| YWHAG | SH3RF3 | 0.961 | 0.258 | bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only | |
| YWHAG | ANKRD34A | 0.952 | bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only | ||
| AKT1S1 | ANKRD34A | 0.481 | bioplex3_WMM boldt boldt_WMM WMM_only | ||
| ANKRD34A | FOXO3 | 0.47 | bioplex3_WMM boldt boldt_WMM WMM_only | ||
| SH3RF3 | ANKRD34A | 0.47 | bioplex3_WMM boldt boldt_WMM WMM_only | ||
| SH3RF3 | FOXO3 | 0.447 | 0.098 | bioplex3_WMM boldt boldt_WMM WMM_only | |
| AKT1S1 | SH3RF3 | 0.437 | 0.15 | bioplex3_WMM boldt boldt_WMM WMM_only | |
| AKT1S1 | FOXO3 | 0.436 | 0.126 | bioplex3_WMM boldt boldt_WMM WMM_only | |
| ZNF395 | FOXO3 | 0.247 | bioplex3_WMM WMM_only | ||
| AKT1S1 | ZNF395 | 0.247 | bioplex3_WMM WMM_only | ||
| ZNF395 | ANKRD34A | 0.079 | bioplex3_WMM WMM_only | ||
| SH3RF3 | ZNF395 | 0.079 | bioplex3_WMM WMM_only |
Related Complexes