hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06136.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TIMELESS | Protein timeless homolog (hTIM) | 5 | UniProt NCBI |
| MCM3 | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | 5 | UniProt NCBI |
| GINS1 | DNA replication complex GINS protein PSF1 (GINS complex subunit 1) | 5 | UniProt NCBI |
| CLSPN | Claspin (hClaspin) | 5 | UniProt NCBI |
| GINS2 | DNA replication complex GINS protein PSF2 (GINS complex subunit 2) | 5 | UniProt NCBI |
| GINS3 | DNA replication complex GINS protein PSF3 (GINS complex subunit 3) | 5 | UniProt NCBI |
| GINS4 | DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed] | 5 | UniProt NCBI |
| TIPIN | TIMELESS-interacting protein | 5 | UniProt NCBI |
| CDC45 | Cell division control protein 45 homolog (PORC-PI-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-176974 | 1.69738107152e-12 | 0.625 | GINS4 GINS2 CDC45 GINS1 GINS3 | Unwinding of DNA |
| CORUM:678 | 3.36110250117e-12 | 0.5 | GINS4 GINS2 GINS1 GINS3 | GINS complex |
| GO:0071162 | 2.32722490539e-10 | 0.625 | GINS4 GINS2 CDC45 GINS1 GINS3 | CMG complex |
| GO:0031261 | 3.98884551806e-10 | 0.625 | GINS4 GINS2 CDC45 GINS1 GINS3 | DNA replication preinitiation complex |
| REAC:R-HSA-69190 | 4.30104656022e-10 | 0.625 | GINS4 GINS2 CDC45 GINS1 GINS3 | DNA strand elongation |
| GO:0000811 | 1.84188417064e-09 | 0.5 | GINS4 GINS2 GINS1 GINS3 | GINS complex |
| GO:0006261 | 2.65721538163e-09 | 0.875 | GINS1 CDC45 TIPIN GINS2 TIMELESS GINS3 GINS4 | DNA-templated DNA replication |
| GO:0006268 | 1.02328314981e-08 | 0.625 | GINS4 GINS2 CDC45 GINS1 GINS3 | DNA unwinding involved in DNA replication |
| GO:0000228 | 1.14204846201e-08 | 0.875 | GINS1 CDC45 TIPIN GINS2 TIMELESS GINS3 GINS4 | nuclear chromosome |
| GO:0006260 | 5.34396095629e-08 | 0.875 | GINS1 CDC45 TIPIN GINS2 TIMELESS GINS3 GINS4 | DNA replication |
| REAC:R-HSA-69239 | 3.84295665702e-07 | 0.625 | GINS4 GINS2 CDC45 GINS1 GINS3 | Synthesis of DNA |
| GO:0032508 | 6.11859846001e-07 | 0.625 | GINS4 GINS2 CDC45 GINS1 GINS3 | DNA duplex unwinding |
| GO:0032392 | 1.4351743773e-06 | 0.625 | GINS4 GINS2 CDC45 GINS1 GINS3 | DNA geometric change |
| REAC:R-HSA-69242 | 1.66077446895e-06 | 0.625 | GINS4 GINS2 CDC45 GINS1 GINS3 | S Phase |
| REAC:R-HSA-69306 | 2.61423596025e-06 | 0.625 | GINS4 GINS2 CDC45 GINS1 GINS3 | DNA Replication |
| GO:0071103 | 2.72810863015e-06 | 0.625 | GINS4 GINS2 CDC45 GINS1 GINS3 | DNA conformation change |
| GO:0000076 | 5.61890325943e-06 | 0.5 | CLSPN CDC45 TIMELESS TIPIN | DNA replication checkpoint signaling |
| REAC:R-HSA-1640170 | 4.06216370762e-05 | 0.75 | GINS2 CLSPN CDC45 GINS1 GINS3 GINS4 | Cell Cycle |
| GO:0033260 | 7.48923430326e-05 | 0.5 | GINS3 CDC45 GINS1 TIPIN | nuclear DNA replication |
| GO:0044786 | 0.000120770447162 | 0.5 | GINS3 CDC45 GINS1 TIPIN | cell cycle DNA replication |
| GO:0006259 | 0.000396845715691 | 0.875 | GINS1 CDC45 TIPIN GINS2 TIMELESS GINS3 GINS4 | DNA metabolic process |
| REAC:R-HSA-69278 | 0.000645311785686 | 0.625 | GINS4 GINS2 CDC45 GINS1 GINS3 | Cell Cycle, Mitotic |
| GO:0000727 | 0.000886327111509 | 0.375 | GINS2 GINS4 CDC45 | double-strand break repair via break-induced replication |
| GO:1902969 | 0.00153551162834 | 0.375 | GINS3 GINS1 CDC45 | mitotic DNA replication |
| REAC:R-HSA-5693607 | 0.00263138488572 | 0.375 | CLSPN TIMELESS TIPIN | Processing of DNA double-strand break ends |
| GO:0032993 | 0.00320293753229 | 0.875 | GINS1 CDC45 TIPIN GINS2 TIMELESS GINS3 GINS4 | protein-DNA complex |
| GO:0140513 | 0.00521846176444 | 0.875 | GINS1 CDC45 TIPIN GINS2 TIMELESS GINS3 GINS4 | nuclear protein-containing complex |
| REAC:R-HSA-5693567 | 0.00672088844441 | 0.375 | CLSPN TIMELESS TIPIN | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.00775010993696 | 0.375 | CLSPN TIMELESS TIPIN | Homology Directed Repair |
| GO:0031570 | 0.012426913615 | 0.5 | CLSPN CDC45 TIMELESS TIPIN | DNA integrity checkpoint signaling |
| REAC:R-HSA-5693532 | 0.0141950226766 | 0.375 | CLSPN TIMELESS TIPIN | DNA Double-Strand Break Repair |
| GO:0006974 | 0.0177166948638 | 0.75 | GINS2 CLSPN TIPIN CDC45 GINS4 TIMELESS | DNA damage response |
| GO:0005694 | 0.0263739534621 | 0.875 | GINS1 CDC45 TIPIN GINS2 TIMELESS GINS3 GINS4 | chromosome |
| REAC:R-HSA-176187 | 0.0348192347107 | 0.25 | CLSPN CDC45 | Activation of ATR in response to replication stress |
| GO:0043111 | 0.0393180950424 | 0.25 | TIMELESS TIPIN | replication fork arrest |
| GO:0031298 | 0.0393180950424 | 0.25 | TIMELESS TIPIN | replication fork protection complex |
| GO:0000724 | 0.0445000722229 | 0.5 | GINS2 CDC45 TIMELESS GINS4 | double-strand break repair via homologous recombination |
| GO:0000725 | 0.0491838271735 | 0.5 | GINS2 CDC45 TIMELESS GINS4 | recombinational repair |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GINS2 | GINS4 | 1.0 | 0.93 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| GINS3 | GINS1 | 1.0 | 0.93 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction |
| TIPIN | TIMELESS | 1.0 | 0.216 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| GINS2 | GINS1 | 1.0 | 0.838 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction |
| GINS2 | GINS3 | 1.0 | 0.908 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction |
| GINS4 | GINS1 | 1.0 | 0.836 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| GINS4 | GINS3 | 1.0 | 0.922 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM Malo fraction |
| GINS4 | TIMELESS | 0.998 | 0.204 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| GINS4 | TIPIN | 0.997 | 0.09 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| CLSPN | GINS4 | 0.996 | 0.12 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| TIPIN | GINS3 | 0.996 | 0.084 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () |
| CLSPN | TIMELESS | 0.995 | 0.124 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| TIMELESS | CDC45 | 0.995 | 0.416 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| GINS3 | TIMELESS | 0.995 | 0.158 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| MCM3 | GINS4 | 0.994 | 0.256 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM fraction |
| MCM3 | GINS3 | 0.993 | 0.646 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| MCM3 | TIPIN | 0.992 | 0.236 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () |
| CLSPN | TIPIN | 0.988 | 0.22 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| GINS3 | CDC45 | 0.984 | 0.474 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MCM3 | TIMELESS | 0.979 | 0.342 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () |
| CLSPN | GINS3 | 0.978 | 0.154 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| GINS1 | CDC45 | 0.976 | 0.316 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| MCM3 | CLSPN | 0.965 | 0.384 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| GINS2 | TIMELESS | 0.952 | 0.092 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| GINS4 | CDC45 | 0.91 | 0.198 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| GINS1 | TIMELESS | 0.908 | 0.128 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| TIPIN | GINS1 | 0.896 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MCM3 | GINS2 | 0.879 | 0.302 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| GINS2 | CDC45 | 0.857 | 0.124 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| MCM3 | GINS1 | 0.841 | 0.404 | bioplex_WMM bioplex3_WMM youn_WMM fraction |
| MCM3 | CDC45 | 0.754 | 0.354 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
| GINS2 | TIPIN | 0.699 | 0.098 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CLSPN | CDC45 | 0.694 | 0.22 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| TIPIN | CDC45 | 0.594 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CLSPN | GINS1 | 0.568 | 0.074 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| GINS2 | CLSPN | 0.401 | 0.078 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes