hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06138.1
Complex Portal: CPX-25570
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIGT | GPI transamidase component PIG-T (Phosphatidylinositol-glycan biosynthesis class T protein) | 5 | UniProt NCBI |
| POMGNT2 | Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2) (EC 2.4.1.312) (Extracellular O-linked N-acetylglucosamine transferase-like) (Glycosyltransferase-like domain-containing protein 2) | 5 | UniProt NCBI |
| B3GNT3 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 (EC 2.4.1.149) (Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) (EC 2.4.1.146) (Beta-1,3-galactosyltransferase 8) (Beta-1,3-GalTase 8) (Beta3Gal-T8) (Beta3GalT8) (b3Gal-T8) (Beta-3-Gx-T8) (Core 1 extending beta-1,3-N-acetylglucosaminyltransferase) (Core1-beta3GlcNAcT) (Transmembrane protein 3) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3) (BGnT-3) (Beta-1,3-Gn-T3) (Beta-1,3-N-acetylglucosaminyltransferase 3) (Beta3Gn-T3) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8) | 5 | UniProt NCBI |
| ARSG | Arylsulfatase G (ASG) (EC 3.1.6.1) (N-sulfoglucosamine-3-sulfatase) (EC 3.1.6.15) | 5 | UniProt NCBI |
| PIGK | GPI-anchor transamidase (GPI transamidase) (EC 3.-.-.-) (GPI8 homolog) (hGPI8) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K) | 5 | UniProt NCBI |
| DGCR2 | Integral membrane protein DGCR2/IDD | 5 | UniProt NCBI |
| ADAM15 | Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:994 | 0.000205125012531 | 0.285714285714 | PIGT PIGK | GAA1-GPI8-PIGT-PIG-PIGS complex |
| REAC:R-HSA-162791 | 0.000799384186586 | 0.285714285714 | PIGT PIGK | Attachment of GPI anchor to uPAR |
| KEGG:00563 | 0.00214596338191 | 0.285714285714 | PIGT PIGK | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis |
| HP:0003282 | 0.00598974417902 | 0.285714285714 | PIGT PIGK | Low alkaline phosphatase |
| REAC:R-HSA-597592 | 0.0148745508598 | 0.714285714286 | B3GNT3 PIGK PIGT ARSG POMGNT2 | Post-translational protein modification |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PIGK | PIGT | 0.999 | 0.984 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| PIGT | ADAM15 | 0.969 | 0.132 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PIGK | B3GNT3 | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ARSG | ADAM15 | 0.965 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PIGK | DGCR2 | 0.959 | 0.11 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| PIGT | DGCR2 | 0.959 | 0.158 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| PIGK | POMGNT2 | 0.958 | 0.09 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| PIGT | B3GNT3 | 0.958 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PIGT | POMGNT2 | 0.956 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| ARSG | DGCR2 | 0.956 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| POMGNT2 | ADAM15 | 0.955 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| DGCR2 | ADAM15 | 0.953 | 0.084 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| POMGNT2 | DGCR2 | 0.952 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only | |
| PIGK | ADAM15 | 0.908 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only | |
| B3GNT3 | ADAM15 | 0.846 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| POMGNT2 | ARSG | 0.469 | bioplex3_WMM WMM_only | ||
| B3GNT3 | DGCR2 | 0.243 | bioplex3_HEK293 bioplex () bioplex3_WMM | ||
| PIGT | ARSG | 0.176 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| POMGNT2 | B3GNT3 | 0.132 | bioplex3_WMM WMM_only | ||
| PIGK | ARSG | 0.128 | bioplex3_HEK293 bioplex () bioplex3_WMM | ||
| B3GNT3 | ARSG | 0.077 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| PIGT | huMAP3_06138.1 huMAP3_06775.1 huMAP3_09327.1 |
| POMGNT2 | huMAP3_06138.1 huMAP3_06449.1 huMAP3_09327.1 huMAP3_10706.1 |
| B3GNT3 | huMAP3_06138.1 huMAP3_10787.1 |
| ARSG | huMAP3_06138.1 huMAP3_07250.1 huMAP3_11122.1 |
| PIGK | huMAP3_01184.1 huMAP3_04873.1 huMAP3_06138.1 huMAP3_10360.1 |
| DGCR2 | huMAP3_06138.1 huMAP3_09398.1 |
| ADAM15 | huMAP3_06138.1 huMAP3_09327.1 |