hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06153.1

Complex Portal: CPX-24395

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
LUZP1	Leucine zipper protein 1	5	UniProt NCBI
TPM3	Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)	5	UniProt NCBI
CROCC	Rootletin (Ciliary rootlet coiled-coil protein)	5	UniProt NCBI
TPM1	Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)	5	UniProt NCBI
TPM4	Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)	5	UniProt NCBI
TPM2	Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005862	3.94689465137e-10	0.666666666667	TPM2 TPM3 TPM4 TPM1	muscle thin filament tropomyosin
WP:WP383	2.9549276464e-08	0.666666666667	TPM2 TPM3 TPM4 TPM1	Striated muscle contraction pathway
REAC:R-HSA-390522	5.91891333952e-08	0.666666666667	TPM2 TPM3 TPM4 TPM1	Striated Muscle Contraction
REAC:R-HSA-445355	9.54895294338e-08	0.666666666667	TPM2 TPM3 TPM4 TPM1	Smooth Muscle Contraction
KEGG:04260	4.17220190946e-07	0.666666666667	TPM2 TPM3 TPM4 TPM1	Cardiac muscle contraction
KEGG:05414	5.20074832828e-07	0.666666666667	TPM2 TPM3 TPM4 TPM1	Dilated cardiomyopathy
KEGG:05410	5.20074832828e-07	0.666666666667	TPM2 TPM3 TPM4 TPM1	Hypertrophic cardiomyopathy
GO:0005865	9.38024124582e-07	0.666666666667	TPM2 TPM3 TPM4 TPM1	striated muscle thin filament
GO:0036379	1.90892139407e-06	0.666666666667	TPM2 TPM3 TPM4 TPM1	myofilament
KEGG:04261	3.20371655146e-06	0.666666666667	TPM2 TPM3 TPM4 TPM1	Adrenergic signaling in cardiomyocytes
KEGG:04814	1.11014436202e-05	0.666666666667	TPM2 TPM3 TPM4 TPM1	Motor proteins
REAC:R-HSA-397014	2.89308744209e-05	0.666666666667	TPM2 TPM3 TPM4 TPM1	Muscle contraction
GO:0005884	0.00109222246905	0.666666666667	TPM2 TPM3 TPM4 TPM1	actin filament
HP:0003198	0.00145544132918	0.666666666667	LUZP1 TPM3 TPM2 TPM1	Myopathy
HP:0001654	0.00213126730767	0.666666666667	LUZP1 TPM3 TPM2 TPM1	Abnormal heart valve morphology
GO:0030017	0.00251106274586	0.666666666667	TPM2 TPM3 TPM4 TPM1	sarcomere
HP:0007110	0.00302198579101	0.333333333333	TPM2 TPM3	Central hypoventilation
GO:0015629	0.00322461566408	0.833333333333	TPM2 TPM1 TPM3 TPM4 CROCC	actin cytoskeleton
HP:0004878	0.00388470114881	0.333333333333	TPM2 TPM3	Intercostal muscle weakness
GO:0030016	0.00428601543329	0.666666666667	TPM2 TPM3 TPM4 TPM1	myofibril
HP:0012727	0.00485475790375	0.5	LUZP1 TPM3 TPM2	Thoracic aortic aneurysm
HP:0002068	0.00485499013014	0.333333333333	TPM2 TPM3	Neuromuscular dysphagia
GO:0043292	0.0054625416235	0.666666666667	TPM2 TPM3 TPM4 TPM1	contractile fiber
HP:0012416	0.00711805296098	0.333333333333	TPM2 TPM3	Hypercapnia
HP:0500164	0.00711805296098	0.333333333333	TPM2 TPM3	Abnormal blood carbon dioxide level
HP:0001648	0.00711805296098	0.333333333333	TPM2 TPM3	Cor pulmonale
HP:0003798	0.00981070246055	0.333333333333	TPM2 TPM3	Nemaline bodies
HPA:0440343	0.0109458365702	0.666666666667	TPM2 TPM3 TPM4 TPM1	skeletal muscle; myocytes[High]
GO:0008307	0.0125202207278	0.5	TPM2 TPM1 TPM4	structural constituent of muscle
HP:0004942	0.0126844263563	0.5	LUZP1 TPM3 TPM2	Aortic aneurysm
GO:0051015	0.0127111069184	0.666666666667	TPM2 TPM3 TPM4 TPM1	actin filament binding
HP:0001638	0.0133234346179	0.666666666667	LUZP1 TPM3 TPM2 TPM1	Cardiomyopathy
HPA:0570793	0.014092620358	0.666666666667	TPM2 TPM3 TPM4 TPM1	testis; round or early spermatids[High]
HP:0009055	0.0146541203169	0.333333333333	TPM2 TPM3	Generalized limb muscle atrophy
HP:0001644	0.0150022431813	0.5	LUZP1 TPM3 TPM1	Dilated cardiomyopathy
REAC:R-HSA-9013424	0.0152705482636	0.333333333333	TPM3 TPM4	RHOV GTPase cycle
HP:0001637	0.0159919169368	0.666666666667	LUZP1 TPM3 TPM2 TPM1	Abnormal myocardium morphology
HP:0011807	0.0164828756284	0.333333333333	TPM2 TPM3	Type 1 muscle fiber atrophy
HP:0006673	0.0164828756284	0.333333333333	TPM2 TPM3	Reduced systolic function
HP:0006705	0.0182726158894	0.5	TPM2 TPM3 TPM1	Abnormal atrioventricular valve morphology
HP:0030200	0.0184186741717	0.333333333333	TPM2 TPM3	Fatiguable weakness of proximal limb muscles
HP:0009004	0.020461457105	0.333333333333	TPM2 TPM3	Hypoplasia of the musculature
GO:0006936	0.0249855480901	0.666666666667	TPM2 TPM3 TPM4 TPM1	muscle contraction
HP:0002617	0.0288997454362	0.5	LUZP1 TPM3 TPM2	Vascular dilatation
HP:0011703	0.0297012565438	0.333333333333	TPM2 TPM3	Sinus tachycardia
REAC:R-HSA-9700206	0.0313533174732	0.333333333333	TPM3 TPM4	Signaling by ALK in cancer
REAC:R-HSA-9725370	0.0313533174732	0.333333333333	TPM3 TPM4	Signaling by ALK fusions and activated point mutants
HPA:0031323	0.0321651383484	0.333333333333	TPM3 TPM1	appendix; enterocytes - Microvilli[High]
HP:0001989	0.0322780794397	0.333333333333	TPM2 TPM3	Fetal akinesia sequence
HP:0002792	0.0322780794397	0.333333333333	TPM2 TPM3	Reduced vital capacity
HP:0100303	0.0322780794397	0.333333333333	TPM2 TPM3	Muscle fiber cytoplasmatic inclusion bodies
HPA:0131323	0.0360051909791	0.333333333333	TPM3 TPM1	colon; enterocytes - Microvilli[High]
HP:0012785	0.0405591774535	0.5	LUZP1 TPM3 TPM2	Flexion contracture of finger
HP:0034681	0.0411521790966	0.5	LUZP1 TPM3 TPM2	Finger joint contracture
HP:0001533	0.0436511011886	0.333333333333	TPM2 TPM3	Slender build
GO:0003012	0.0460543825493	0.666666666667	TPM2 TPM3 TPM4 TPM1	muscle system process
HPA:0401323	0.0465379666742	0.333333333333	TPM3 TPM1	rectum; enterocytes - Microvilli[High]
GO:0097517	0.0473097913612	0.5	TPM3 TPM4 TPM1	contractile actin filament bundle
GO:0001725	0.0473097913612	0.5	TPM3 TPM4 TPM1	stress fiber

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
TPM1	TPM4	1.0		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
TPM3	TPM4	0.999	0.158	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only
TPM1	TPM3	0.997		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM
TPM4	TPM2	0.997	0.146	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
TPM1	TPM2	0.997		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
CROCC	TPM1	0.997		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TPM3	TPM2	0.994	0.15	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
LUZP1	TPM4	0.99	0.034	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
LUZP1	TPM3	0.989	0.064	hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only
LUZP1	TPM2	0.979	0.086	hein_WMM bioplex3_WMM WMM_only boldt_WMM
TPM1	LUZP1	0.959		hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only
CROCC	TPM3	0.948	0.058	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CROCC	TPM2	0.815	0.101411764706	bioplex_WMM bioplex3_WMM WMM_only
CROCC	TPM4	0.779	0.034	bioplex_WMM bioplex3_WMM WMM_only
CROCC	LUZP1	0.413	0.068	bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
LUZP1	huMAP3_05977.1 huMAP3_06153.1
TPM3	huMAP3_06153.1 huMAP3_07595.1 huMAP3_08088.1 huMAP3_09542.1
CROCC	huMAP3_01231.1 huMAP3_04813.1 huMAP3_06153.1 huMAP3_07954.1 huMAP3_08088.1 huMAP3_13271.1 huMAP3_14032.1
TPM1	huMAP3_01231.1 huMAP3_06153.1 huMAP3_08088.1 huMAP3_08205.1 huMAP3_09542.1
TPM4	huMAP3_06153.1 huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1
TPM2	huMAP3_06153.1 huMAP3_06763.1 huMAP3_09121.1 huMAP3_13838.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06153.1

Complex Portal: CPX-24395