hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06179.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RRAS | Ras-related protein R-Ras (EC 3.6.5.-) (p23) | 5 | UniProt NCBI |
| RAP2C | Ras-related protein Rap-2c (EC 3.6.5.2) | 5 | UniProt NCBI |
| RAC3 | Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3) | 5 | UniProt NCBI |
| RAP1A | Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1) | 5 | UniProt NCBI |
| RRAS2 | Ras-related protein R-Ras2 (EC 3.6.5.-) (Ras-like protein TC21) (Teratocarcinoma oncogene) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4223 | 0.000179947709834 | 0.75 | RAC3 RAP1A RRAS2 | Ras signaling |
| KEGG:04024 | 0.000219642829889 | 0.75 | RAC3 RAP1A RRAS2 | cAMP signaling pathway |
| KEGG:04014 | 0.000347369255466 | 0.75 | RAC3 RAP1A RRAS2 | Ras signaling pathway |
| WP:WP382 | 0.000461288756706 | 0.75 | RAC3 RAP1A RRAS2 | MAPK signaling pathway |
| KEGG:04010 | 0.000800866642312 | 0.75 | RAC3 RAP1A RRAS2 | MAPK signaling pathway |
| GO:0005525 | 0.000993378785041 | 1.0 | RAC3 RAP2C RRAS2 RAP1A | GTP binding |
| GO:0032561 | 0.00156892706691 | 1.0 | RAC3 RAP2C RRAS2 RAP1A | guanyl ribonucleotide binding |
| GO:0019001 | 0.00160144369006 | 1.0 | RAC3 RAP2C RRAS2 RAP1A | guanyl nucleotide binding |
| GO:0003924 | 0.00366770658506 | 1.0 | RAC3 RAP2C RRAS2 RAP1A | GTPase activity |
| WP:WP185 | 0.00883615359641 | 0.5 | RAC3 RAP1A | Integrin mediated cell adhesion |
| KEGG:04520 | 0.00909742323246 | 0.5 | RAC3 RAP1A | Adherens junction |
| GO:0007264 | 0.0103222422745 | 1.0 | RAC3 RAP2C RRAS2 RAP1A | small GTPase-mediated signal transduction |
| GO:0019003 | 0.0152210712647 | 0.75 | RAP2C RRAS2 RAP1A | GDP binding |
| GO:0017111 | 0.0191409054275 | 1.0 | RAC3 RAP2C RRAS2 RAP1A | ribonucleoside triphosphate phosphatase activity |
| WP:WP51 | 0.0205195911139 | 0.5 | RAC3 RRAS2 | Regulation of actin cytoskeleton |
| KEGG:04062 | 0.0237566589162 | 0.5 | RAC3 RAP1A | Chemokine signaling pathway |
| KEGG:04530 | 0.0237566589162 | 0.5 | RAP2C RAP1A | Tight junction |
| GO:0016818 | 0.0305291540849 | 1.0 | RAC3 RAP2C RRAS2 RAP1A | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| GO:0016462 | 0.0305291540849 | 1.0 | RAC3 RAP2C RRAS2 RAP1A | pyrophosphatase activity |
| GO:0016817 | 0.0305291540849 | 1.0 | RAC3 RAP2C RRAS2 RAP1A | hydrolase activity, acting on acid anhydrides |
| GO:0035639 | 0.0326761482103 | 1.0 | RAC3 RAP2C RRAS2 RAP1A | purine ribonucleoside triphosphate binding |
| KEGG:04015 | 0.0338381888916 | 0.5 | RAC3 RAP1A | Rap1 signaling pathway |
| KEGG:04510 | 0.03673756538 | 0.5 | RAC3 RAP1A | Focal adhesion |
| WP:WP306 | 0.0374055211141 | 0.5 | RAC3 RAP1A | Focal adhesion |
| KEGG:04810 | 0.0466115978004 | 0.5 | RAC3 RRAS2 | Regulation of actin cytoskeleton |
| CORUM:2256 | 0.049938562206 | 0.25 | RAP1A | RIAM-Rap1-GTP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RRAS | RRAS2 | 0.997 | 0.562 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| RRAS2 | RAP2C | 0.993 | 0.078 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RRAS2 | RAP1A | 0.99 | 0.1 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| RAC3 | RAP1A | 0.988 | 0.086 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| RAP2C | RAP1A | 0.973 | 0.126 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| RAC3 | RRAS2 | 0.969 | 0.154333988212 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| RAC3 | RAP2C | 0.961 | 0.038 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| RRAS | RAP2C | 0.924 | 0.04 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| RRAS | RAP1A | 0.499 | 0.274 | hein_WMM bioplex3_WMM WMM_only |
| RAC3 | RRAS | 0.061 | 0.128 | hein_WMM bioplex3_WMM WMM_only |
Related Complexes