hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06185.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WDR87 | WD repeat-containing protein 87 (Testis development protein NYD-SP11) | 3 | UniProt NCBI |
| HDAC3 | Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45) | 5 | UniProt NCBI |
| NCOR1 | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | 5 | UniProt NCBI |
| TBL1Y | F-box-like/WD repeat-containing protein TBL1Y (Transducin beta-like protein 1Y) (Transducin-beta-like protein 1, Y-linked) | 5 | UniProt NCBI |
| TBL1XR1 | F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1) | 5 | UniProt NCBI |
| NCOR2 | Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor) | 5 | UniProt NCBI |
| ANKRD11 | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | 5 | UniProt NCBI |
| GPS2 | G protein pathway suppressor 2 (GPS-2) | 5 | UniProt NCBI |
| TBL1X | F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9022537 | 1.47215047799e-18 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Loss of MECP2 binding ability to the NCoR/SMRT complex |
| REAC:R-HSA-9005895 | 3.08933976061e-16 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Pervasive developmental disorders |
| REAC:R-HSA-9005891 | 3.08933976061e-16 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Loss of function of MECP2 in Rett syndrome |
| REAC:R-HSA-9697154 | 3.08933976061e-16 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Disorders of Nervous System Development |
| REAC:R-HSA-9675151 | 3.08933976061e-16 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Disorders of Developmental Biology |
| CORUM:741 | 1.84180722403e-15 | 0.555555555556 | TBL1X HDAC3 GPS2 NCOR1 TBL1XR1 | NCOR-HDAC3 complex |
| CORUM:58 | 1.84180722403e-15 | 0.555555555556 | TBL1X HDAC3 GPS2 NCOR2 TBL1XR1 | SMRT complex |
| CORUM:15 | 1.10483220475e-14 | 0.555555555556 | TBL1X HDAC3 GPS2 NCOR1 TBL1XR1 | NCOR complex |
| CORUM:2183 | 4.63606134522e-13 | 0.555555555556 | TBL1X HDAC3 GPS2 NCOR1 TBL1XR1 | Kaiso-NCOR complex |
| REAC:R-HSA-9022692 | 6.9647360974e-13 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Regulation of MECP2 expression and activity |
| REAC:R-HSA-9029569 | 1.07915359371e-12 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
| REAC:R-HSA-9024446 | 4.77522655503e-12 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | NR1H2 and NR1H3-mediated signaling |
| REAC:R-HSA-8986944 | 3.35180405683e-11 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-350054 | 1.41050263113e-10 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | Notch-HLH transcription pathway |
| REAC:R-HSA-3214815 | 4.36644546891e-10 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | HDACs deacetylate histones |
| REAC:R-HSA-1989781 | 1.62273319069e-09 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | PPARA activates gene expression |
| REAC:R-HSA-400206 | 1.72600644838e-09 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Regulation of lipid metabolism by PPARalpha |
| WP:WP4312 | 1.74636239523e-09 | 0.555555555556 | TBL1X TBL1XR1 GPS2 NCOR1 NCOR2 | Rett syndrome causing genes |
| REAC:R-HSA-2122947 | 3.50995957276e-09 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-9609690 | 5.27021742229e-09 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | HCMV Early Events |
| REAC:R-HSA-2894862 | 8.16928355944e-09 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| REAC:R-HSA-2644606 | 8.16928355944e-09 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2894858 | 8.16928355944e-09 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644602 | 8.16928355944e-09 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644603 | 8.16928355944e-09 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | Signaling by NOTCH1 in Cancer |
| GO:0017053 | 1.245788325e-08 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | transcription repressor complex |
| CORUM:7480 | 1.31072783286e-08 | 0.333333333333 | HDAC3 NCOR1 NCOR2 | HDAC3-H1.3-SMRT-N-Cor complex |
| CORUM:1188 | 1.31072783286e-08 | 0.333333333333 | HDAC3 NCOR2 TBL1X | SMRT core complex |
| CORUM:752 | 1.31072783286e-08 | 0.333333333333 | HDAC3 NCOR2 TBL1X | SMRT core complex |
| REAC:R-HSA-9609646 | 1.47039095704e-08 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | HCMV Infection |
| REAC:R-HSA-1980143 | 2.65893726912e-08 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | Signaling by NOTCH1 |
| REAC:R-HSA-9707564 | 2.65893726912e-08 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | Cytoprotection by HMOX1 |
| GO:0003714 | 2.79243559023e-08 | 0.777777777778 | GPS2 TBL1Y TBL1X HDAC3 NCOR2 TBL1XR1 NCOR1 | transcription corepressor activity |
| REAC:R-HSA-381340 | 9.1331069582e-08 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | Transcriptional regulation of white adipocyte differentiation |
| REAC:R-HSA-9006931 | 4.18484631995e-07 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Signaling by Nuclear Receptors |
| REAC:R-HSA-4839726 | 4.5001456838e-07 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Chromatin organization |
| REAC:R-HSA-3247509 | 4.5001456838e-07 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Chromatin modifying enzymes |
| CORUM:1505 | 4.58189849981e-07 | 0.333333333333 | HDAC3 NCOR1 NCOR2 | NCOR2 complex |
| REAC:R-HSA-9707616 | 1.74050956917e-06 | 0.444444444444 | TBL1X HDAC3 NCOR1 TBL1XR1 | Heme signaling |
| REAC:R-HSA-2151201 | 3.0207398275e-06 | 0.444444444444 | TBL1X HDAC3 NCOR1 TBL1XR1 | Transcriptional activation of mitochondrial biogenesis |
| REAC:R-HSA-400253 | 8.07264008546e-06 | 0.444444444444 | TBL1X HDAC3 NCOR1 TBL1XR1 | Circadian Clock |
| REAC:R-HSA-9711123 | 8.3553871124e-06 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | Cellular response to chemical stress |
| GO:0000118 | 8.53456380768e-06 | 0.555555555556 | TBL1X HDAC3 NCOR1 TBL1XR1 TBL1Y | histone deacetylase complex |
| CORUM:5614 | 1.26384976661e-05 | 0.333333333333 | HDAC3 TBL1Y TBL1XR1 | Emerin complex 32 |
| REAC:R-HSA-157118 | 1.43960050398e-05 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | Signaling by NOTCH |
| GO:0003712 | 2.51002472958e-05 | 0.777777777778 | GPS2 TBL1Y TBL1X HDAC3 NCOR2 TBL1XR1 NCOR1 | transcription coregulator activity |
| CORUM:5426 | 2.73623797451e-05 | 0.222222222222 | HDAC3 ANKRD11 | ANCO1-HDAC3 complex |
| REAC:R-HSA-1592230 | 3.26247422283e-05 | 0.444444444444 | TBL1X HDAC3 NCOR1 TBL1XR1 | Mitochondrial biogenesis |
| REAC:R-HSA-556833 | 9.40411082062e-05 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Metabolism of lipids |
| REAC:R-HSA-9824446 | 0.000213160163792 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Viral Infection Pathways |
| REAC:R-HSA-1368071 | 0.000239571230342 | 0.222222222222 | HDAC3 NCOR1 | NR1D1 (REV-ERBA) represses gene expression |
| REAC:R-HSA-5663202 | 0.000281746384369 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | Diseases of signal transduction by growth factor receptors and second messengers |
| REAC:R-HSA-5663205 | 0.000716014897471 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Infectious disease |
| GO:0005667 | 0.00083171054209 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | transcription regulator complex |
| CORUM:1413 | 0.00122816473062 | 0.222222222222 | HDAC3 NCOR1 | NCOR1 complex |
| GO:0030674 | 0.00164396280271 | 0.777777777778 | GPS2 TBL1Y TBL1X HDAC3 NCOR2 TBL1XR1 NCOR1 | protein-macromolecule adaptor activity |
| REAC:R-HSA-212436 | 0.00194258475403 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Generic Transcription Pathway |
| REAC:R-HSA-9623433 | 0.00286935042585 | 0.222222222222 | NCOR1 NCOR2 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis |
| REAC:R-HSA-1852241 | 0.00339962776506 | 0.444444444444 | TBL1X HDAC3 NCOR1 TBL1XR1 | Organelle biogenesis and maintenance |
| REAC:R-HSA-73857 | 0.00367767854286 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | RNA Polymerase II Transcription |
| KEGG:04310 | 0.00430102432376 | 0.333333333333 | TBL1XR1 TBL1Y TBL1X | Wnt signaling pathway |
| GO:0060090 | 0.00486640736746 | 0.777777777778 | GPS2 TBL1Y TBL1X HDAC3 NCOR2 TBL1XR1 NCOR1 | molecular adaptor activity |
| REAC:R-HSA-2262752 | 0.00738791222428 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | Cellular responses to stress |
| REAC:R-HSA-74160 | 0.00759942737987 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Gene expression (Transcription) |
| REAC:R-HSA-8953897 | 0.0077407268337 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | Cellular responses to stimuli |
| REAC:R-HSA-1368082 | 0.00954313848115 | 0.222222222222 | TBL1XR1 TBL1X | RORA activates gene expression |
| HPA:0170252 | 0.0157326839444 | 0.666666666667 | TBL1X HDAC3 ANKRD11 NCOR2 TBL1XR1 NCOR1 | endometrium 2; cells in endometrial stroma[>=Medium] |
| REAC:R-HSA-1266738 | 0.0165011170168 | 0.555555555556 | TBL1X HDAC3 NCOR1 NCOR2 TBL1XR1 | Developmental Biology |
| REAC:R-HSA-1643685 | 0.0165408171212 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Disease |
| REAC:R-HSA-1368108 | 0.0200751738188 | 0.222222222222 | TBL1XR1 TBL1X | BMAL1:CLOCK,NPAS2 activates circadian gene expression |
| GO:0000122 | 0.0206219094099 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | negative regulation of transcription by RNA polymerase II |
| WP:WP61 | 0.0287089830042 | 0.222222222222 | NCOR1 NCOR2 | Notch signaling pathway |
| HPA:0490692 | 0.0289589517706 | 0.777777777778 | GPS2 TBL1X HDAC3 ANKRD11 NCOR2 TBL1XR1 NCOR1 | smooth muscle; smooth muscle cells[>=Medium] |
| REAC:R-HSA-2173795 | 0.032153801025 | 0.222222222222 | NCOR1 NCOR2 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| GO:0046329 | 0.0359812030822 | 0.333333333333 | HDAC3 NCOR1 GPS2 | negative regulation of JNK cascade |
| REAC:R-HSA-383280 | 0.0392438573551 | 0.222222222222 | NCOR1 NCOR2 | Nuclear Receptor transcription pathway |
| REAC:R-HSA-1430728 | 0.0452440709483 | 0.666666666667 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 NCOR1 | Metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NCOR1 | GPS2 | 1.0 | 0.152 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NCOR2 | GPS2 | 1.0 | 0.274 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| TBL1XR1 | GPS2 | 1.0 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| GPS2 | HDAC3 | 1.0 | 0.2296 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| GPS2 | TBL1X | 1.0 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| NCOR2 | TBL1Y | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ANKRD11 | GPS2 | 0.999 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| GPS2 | TBL1Y | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TBL1X | TBL1Y | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NCOR1 | TBL1Y | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HDAC3 | TBL1Y | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TBL1XR1 | TBL1Y | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WDR87 | GPS2 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NCOR1 | TBL1XR1 | 0.969 | 0.148 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| NCOR1 | HDAC3 | 0.959 | 0.28 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| NCOR2 | TBL1X | 0.955 | 0.216 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ANKRD11 | TBL1X | 0.954 | 0.066 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ANKRD11 | HDAC3 | 0.952 | 0.366 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NCOR1 | TBL1X | 0.95 | 0.154 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| TBL1XR1 | HDAC3 | 0.948 | 0.304 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| NCOR2 | ANKRD11 | 0.92 | 0.288 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NCOR2 | HDAC3 | 0.919 | 0.4 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| TBL1XR1 | ANKRD11 | 0.913 | 0.134 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| TBL1XR1 | TBL1X | 0.91 | 0.954 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| WDR87 | ANKRD11 | 0.908 | bioplex3_WMM WMM_only | |
| TBL1X | HDAC3 | 0.892 | 0.4 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| TBL1XR1 | NCOR2 | 0.89 | 0.124 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| WDR87 | NCOR2 | 0.89 | bioplex3_WMM WMM_only | |
| NCOR1 | ANKRD11 | 0.885 | 0.242 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| WDR87 | TBL1X | 0.715 | bioplex3_WMM WMM_only | |
| NCOR1 | NCOR2 | 0.676 | 0.19 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| WDR87 | NCOR1 | 0.675 | bioplex3_WMM WMM_only | |
| WDR87 | TBL1XR1 | 0.654 | bioplex3_WMM WMM_only | |
| WDR87 | HDAC3 | 0.312 | bioplex3_WMM WMM_only |
Related Complexes