hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06194.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LTBP3 | Latent-transforming growth factor beta-binding protein 3 (LTBP-3) | 5 | UniProt NCBI |
| FBLN5 | Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50) | 5 | UniProt NCBI |
| DNAJC10 | DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr) | 5 | UniProt NCBI |
| LTBP4 | Latent-transforming growth factor beta-binding protein 4 (LTBP-4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2129379 | 5.12049513312e-06 | 0.75 | LTBP3 FBLN5 LTBP4 | Molecules associated with elastic fibres |
| REAC:R-HSA-1566948 | 1.00019654619e-05 | 0.75 | LTBP3 FBLN5 LTBP4 | Elastic fibre formation |
| HP:0012619 | 0.000200620835246 | 0.5 | LTBP4 FBLN5 | Multiple bladder diverticula |
| REAC:R-HSA-1474244 | 0.00270393678592 | 0.75 | LTBP3 FBLN5 LTBP4 | Extracellular matrix organization |
| REAC:R-HSA-2173789 | 0.00837722051003 | 0.5 | LTBP3 LTBP4 | TGF-beta receptor signaling activates SMADs |
| HP:0002090 | 0.0126315731793 | 0.75 | LTBP3 FBLN5 LTBP4 | Pneumonia |
| HP:0000015 | 0.0176079483787 | 0.5 | LTBP4 FBLN5 | Bladder diverticulum |
| HP:0005607 | 0.0221521745039 | 0.75 | LTBP3 FBLN5 LTBP4 | Abnormal tracheobronchial morphology |
| HP:0004969 | 0.0234332085093 | 0.5 | LTBP4 FBLN5 | Peripheral pulmonary artery stenosis |
| REAC:R-HSA-170834 | 0.0380580405855 | 0.5 | LTBP3 LTBP4 | Signaling by TGF-beta Receptor Complex |
| HP:0002097 | 0.0458701548093 | 0.5 | LTBP4 FBLN5 | Emphysema |
| CORUM:6914 | 0.049938562206 | 0.25 | FBLN5 | ELN-FBLN5-FBN1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LTBP4 | DNAJC10 | 0.983 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| DNAJC10 | LTBP3 | 0.971 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| FBLN5 | LTBP4 | 0.97 | 0.152 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| FBLN5 | DNAJC10 | 0.96 | 0.098 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LTBP4 | LTBP3 | 0.929 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only |
| FBLN5 | LTBP3 | 0.769 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes