hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06208.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) | 5 | UniProt NCBI |
| RNF25 | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7) | 5 | UniProt NCBI |
| UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-168927 | 0.0011650518872 | 0.666666666667 | UBE2D3 UBE2D1 | TICAM1, RIP1-mediated IKK complex recruitment |
| REAC:R-HSA-937041 | 0.00129444299395 | 0.666666666667 | UBE2D3 UBE2D1 | IKK complex recruitment mediated by RIP1 |
| REAC:R-HSA-9705462 | 0.00172341693863 | 0.666666666667 | UBE2D3 UBE2D1 | Inactivation of CSF3 (G-CSF) signaling |
| REAC:R-HSA-983168 | 0.00172547605388 | 1.0 | UBE2D3 RNF25 UBE2D1 | Antigen processing: Ubiquitination & Proteasome degradation |
| REAC:R-HSA-201451 | 0.00204339075673 | 0.666666666667 | UBE2D3 UBE2D1 | Signaling by BMP |
| WP:WP183 | 0.00206734131669 | 0.666666666667 | UBE2D3 UBE2D1 | Proteasome degradation |
| KEGG:03083 | 0.0024644071062 | 0.666666666667 | UBE2D3 UBE2D1 | Polycomb repressive complex |
| REAC:R-HSA-9674555 | 0.00257431960226 | 0.666666666667 | UBE2D3 UBE2D1 | Signaling by CSF3 (G-CSF) |
| REAC:R-HSA-2173795 | 0.00276488364952 | 0.666666666667 | UBE2D3 UBE2D1 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| REAC:R-HSA-983169 | 0.00319336906176 | 1.0 | UBE2D3 RNF25 UBE2D1 | Class I MHC mediated antigen processing & presentation |
| REAC:R-HSA-936440 | 0.00359505378021 | 0.666666666667 | UBE2D3 UBE2D1 | Negative regulators of DDX58/IFIH1 signaling |
| REAC:R-HSA-5357905 | 0.00643790104829 | 0.666666666667 | UBE2D3 UBE2D1 | Regulation of TNFR1 signaling |
| KEGG:04120 | 0.00686279305854 | 0.666666666667 | UBE2D3 UBE2D1 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-9033241 | 0.00767507889467 | 0.666666666667 | UBE2D3 UBE2D1 | Peroxisomal protein import |
| REAC:R-HSA-2173793 | 0.00833431912959 | 0.666666666667 | UBE2D3 UBE2D1 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| KEGG:04141 | 0.00916431091176 | 0.666666666667 | UBE2D3 UBE2D1 | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-75893 | 0.00937397262456 | 0.666666666667 | UBE2D3 UBE2D1 | TNF signaling |
| REAC:R-HSA-8866654 | 0.00973406489476 | 0.666666666667 | UBE2D3 UBE2D1 | E3 ubiquitin ligases ubiquitinate target proteins |
| REAC:R-HSA-1234176 | 0.0132793882188 | 0.666666666667 | UBE2D3 UBE2D1 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| REAC:R-HSA-1234174 | 0.0164154902665 | 0.666666666667 | UBE2D3 UBE2D1 | Cellular response to hypoxia |
| REAC:R-HSA-8852135 | 0.0183561585619 | 0.666666666667 | UBE2D3 UBE2D1 | Protein ubiquitination |
| REAC:R-HSA-168928 | 0.0188582038017 | 0.666666666667 | UBE2D3 UBE2D1 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| KEGG:05131 | 0.0193802248568 | 0.666666666667 | UBE2D3 UBE2D1 | Shigellosis |
| REAC:R-HSA-1280218 | 0.0226639223828 | 1.0 | UBE2D3 RNF25 UBE2D1 | Adaptive Immune System |
| REAC:R-HSA-170834 | 0.0254089329805 | 0.666666666667 | UBE2D3 UBE2D1 | Signaling by TGF-beta Receptor Complex |
| REAC:R-HSA-168164 | 0.0278082114556 | 0.666666666667 | UBE2D3 UBE2D1 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166166 | 0.0290482612381 | 0.666666666667 | UBE2D3 UBE2D1 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 0.0290482612381 | 0.666666666667 | UBE2D3 UBE2D1 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-9006936 | 0.0392065258044 | 0.666666666667 | UBE2D3 UBE2D1 | Signaling by TGFB family members |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RNF25 | UBE2D3 | 0.998 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D1 | 0.997 | 0.144 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| UBE2D3 | UBE2D1 | 0.975 | 0.369636363636 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes