hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06211.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ACVR2B | Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB) | 5 | UniProt NCBI |
| ACVR1 | Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) | 5 | UniProt NCBI |
| EPHA2 | Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04350 | 0.000608173227025 | 1.0 | ACVR1 ACVR2B | TGF-beta signaling pathway |
| KEGG:05418 | 0.0011031979467 | 1.0 | ACVR1 ACVR2B | Fluid shear stress and atherosclerosis |
| KEGG:04550 | 0.00116074761854 | 1.0 | ACVR1 ACVR2B | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04060 | 0.0031385705215 | 1.0 | ACVR1 ACVR2B | Cytokine-cytokine receptor interaction |
| WP:WP2857 | 0.00340552178308 | 1.0 | ACVR1 ACVR2B | Mesodermal commitment pathway |
| GO:0048179 | 0.00468200720083 | 1.0 | ACVR1 ACVR2B | activin receptor complex |
| GO:0048185 | 0.00983221512175 | 1.0 | ACVR1 ACVR2B | activin binding |
| GO:0017002 | 0.0131096201623 | 1.0 | ACVR1 ACVR2B | activin receptor activity |
| GO:0004675 | 0.0426062655276 | 1.0 | ACVR1 ACVR2B | transmembrane receptor protein serine/threonine kinase activity |
| HP:0008449 | 0.0499436884913 | 0.5 | ACVR1 | Progressive cervical vertebral spine fusion |
| HP:0010452 | 0.0499436884913 | 0.5 | ACVR2B | Ectopia of the spleen |
| HP:0011987 | 0.0499436884913 | 0.5 | ACVR1 | Ectopic ossification in muscle tissue |
| HP:0011988 | 0.0499436884913 | 0.5 | ACVR1 | Ectopic ossification in tendon tissue |
| HP:0011989 | 0.0499436884913 | 0.5 | ACVR1 | Ectopic ossification in ligament tissue |
| HP:0034188 | 0.0499436884913 | 0.5 | ACVR2B | Midline liver |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ACVR2B | ACVR1 | 0.984 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACVR2B | EPHA2 | 0.964 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACVR1 | EPHA2 | 0.699 | 0.244 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes