hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06217.1
Complex Portal: CPX-23108
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| XPNPEP1 | Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) | 5 | UniProt NCBI |
| RHOA | Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12) | 5 | UniProt NCBI |
| RAP1GDS1 | Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein) | 5 | UniProt NCBI |
| RAC3 | Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3) | 5 | UniProt NCBI |
| RAP1B | Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04520 | 9.46922201828e-05 | 0.6 | RHOA RAP1B RAC3 | Adherens junction |
| KEGG:04062 | 0.000403047923682 | 0.6 | RHOA RAP1B RAC3 | Chemokine signaling pathway |
| KEGG:04024 | 0.000592339283786 | 0.6 | RHOA RAP1B RAC3 | cAMP signaling pathway |
| WP:WP4223 | 0.000617085733732 | 0.6 | RHOA RAP1B RAC3 | Ras signaling |
| KEGG:04015 | 0.000687014133415 | 0.6 | RHOA RAP1B RAC3 | Rap1 signaling pathway |
| KEGG:04510 | 0.0007776530092 | 0.6 | RHOA RAP1B RAC3 | Focal adhesion |
| KEGG:04014 | 0.000935536894331 | 0.6 | RHOA RAP1B RAC3 | Ras signaling pathway |
| WP:WP306 | 0.00100625954708 | 0.6 | RHOA RAP1B RAC3 | Focal adhesion |
| KEGG:04972 | 0.0115077320087 | 0.4 | RHOA RAP1B | Pancreatic secretion |
| WP:WP4216 | 0.0128896073912 | 0.4 | RHOA RAC3 | Chromosomal and microsatellite instability in colorectal cancer |
| KEGG:05210 | 0.0135091080522 | 0.4 | RHOA RAC3 | Colorectal cancer |
| WP:WP2355 | 0.0161598479529 | 0.4 | RHOA RAP1B | Corticotropin releasing hormone signaling pathway |
| KEGG:04670 | 0.0164241113683 | 0.4 | RHOA RAP1B | Leukocyte transendothelial migration |
| WP:WP4263 | 0.0188521857166 | 0.4 | RHOA RAC3 | Pancreatic adenocarcinoma pathway |
| WP:WP185 | 0.020275205407 | 0.4 | RAC3 RAP1B | Integrin mediated cell adhesion |
| KEGG:04611 | 0.0213229262457 | 0.4 | RHOA RAP1B | Platelet activation |
| KEGG:04722 | 0.0222006100833 | 0.4 | RHOA RAP1B | Neurotrophin signaling pathway |
| KEGG:04071 | 0.0235498516465 | 0.4 | RHOA RAC3 | Sphingolipid signaling pathway |
| WP:WP710 | 0.0293032373139 | 0.4 | RHOA RAC3 | DNA damage response only ATM dependent |
| KEGG:05135 | 0.0293384756517 | 0.4 | RHOA RAC3 | Yersinia infection |
| KEGG:05418 | 0.0303640260346 | 0.4 | RHOA RAC3 | Fluid shear stress and atherosclerosis |
| WP:WP51 | 0.046989062869 | 0.4 | RHOA RAC3 | Regulation of actin cytoskeleton |
| KEGG:04310 | 0.0497762971898 | 0.4 | RHOA RAC3 | Wnt signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RHOA | RAP1GDS1 | 0.991 | 0.387095238095 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| RAP1GDS1 | RAP1B | 0.991 | 0.07 |
structurally_consistent (P61586)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RHOA | RAC3 | 0.988 | 0.35 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| XPNPEP1 | RHOA | 0.977 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RHOA | RAP1B | 0.973 | 0.371583333333 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt gupta_WMM fraction boldt_WMM |
| RAC3 | RAP1B | 0.961 | 0.0863339882122 |
mutually_exclusive (P52306)
|
hein_WMM bioplex_WMM bioplex3_WMM fraction |
| RAP1GDS1 | RAC3 | 0.735 | 0.142 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| XPNPEP1 | RAP1B | 0.095 |
structurally_consistent (P61586)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| XPNPEP1 | RAC3 | 0.025 | bioplex3_WMM WMM_only |
Related Complexes