hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06219.1
Complex Portal: CPX-19726
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SAP18 | Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18) | 5 | UniProt NCBI |
| LUC7L2 | Putative RNA-binding protein Luc7-like 2 | 5 | UniProt NCBI |
| CCDC9 | Coiled-coil domain-containing protein 9 | 4 | UniProt NCBI |
| NKTR | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | 5 | UniProt NCBI |
| ACIN1 | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | 5 | UniProt NCBI |
| CLK2 | Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) | 5 | UniProt NCBI |
| PPIG | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:760 | 6.1565588648e-05 | 0.285714285714 | ACIN1 SAP18 | Apoptosis- and splicing-associated protein complex (ASAP-L), SAP18, RNPS1, Acinus-L |
| GO:0035145 | 0.00382182132582 | 0.428571428571 | CCDC9 SAP18 ACIN1 | exon-exon junction complex |
| HPA:0301372 | 0.00580454207605 | 0.714285714286 | PPIG CCDC9 CLK2 SAP18 ACIN1 | lung; alveolar cells type II[>=Medium] |
| HPA:0160251 | 0.00675933198392 | 1.0 | PPIG LUC7L2 SAP18 CCDC9 ACIN1 CLK2 NKTR | endometrium 1; cells in endometrial stroma[>=Low] |
| GO:0008380 | 0.00965864313965 | 0.714285714286 | PPIG LUC7L2 CLK2 SAP18 ACIN1 | RNA splicing |
| HPA:0100201 | 0.0154029798657 | 1.0 | PPIG LUC7L2 SAP18 CCDC9 ACIN1 CLK2 NKTR | cerebral cortex; endothelial cells[>=Low] |
| HPA:0301371 | 0.0166031206858 | 0.714285714286 | PPIG CCDC9 CLK2 SAP18 ACIN1 | lung; alveolar cells type II[>=Low] |
| REAC:R-HSA-72163 | 0.0166902174261 | 0.428571428571 | ACIN1 SAP18 PPIG | mRNA Splicing - Major Pathway |
| HPA:0210052 | 0.0175216095547 | 1.0 | PPIG LUC7L2 SAP18 CCDC9 ACIN1 CLK2 NKTR | fallopian tube; glandular cells[>=Medium] |
| HPA:0030071 | 0.0181110839557 | 1.0 | PPIG LUC7L2 SAP18 CCDC9 ACIN1 CLK2 NKTR | appendix; lymphoid tissue[>=Low] |
| REAC:R-HSA-72172 | 0.0184779747348 | 0.428571428571 | ACIN1 SAP18 PPIG | mRNA Splicing |
| HPA:0320102 | 0.0187790608236 | 1.0 | PPIG LUC7L2 SAP18 CCDC9 ACIN1 CLK2 NKTR | nasopharynx; respiratory epithelial cells[>=Medium] |
| HPA:0570811 | 0.0191101015746 | 0.857142857143 | PPIG LUC7L2 SAP18 CCDC9 CLK2 NKTR | testis; spermatogonia cells[>=Low] |
| HPA:0090933 | 0.0258802587603 | 0.285714285714 | ACIN1 SAP18 | cerebellum; GLUC cells - nucleus[High] |
| HPA:0600222 | 0.0259260211515 | 1.0 | PPIG LUC7L2 SAP18 CCDC9 ACIN1 CLK2 NKTR | tonsil; squamous epithelial cells[>=Medium] |
| HPA:0130241 | 0.0261709346046 | 1.0 | PPIG LUC7L2 SAP18 CCDC9 ACIN1 CLK2 NKTR | colon; peripheral nerve/ganglion[>=Low] |
| HPA:0570781 | 0.0284194718187 | 0.714285714286 | PPIG LUC7L2 CLK2 SAP18 CCDC9 | testis; preleptotene spermatocytes[>=Low] |
| HPA:0190222 | 0.0294038225527 | 1.0 | PPIG LUC7L2 SAP18 CCDC9 ACIN1 CLK2 NKTR | esophagus; squamous epithelial cells[>=Medium] |
| HPA:0090913 | 0.0312236155183 | 0.285714285714 | ACIN1 SAP18 | cerebellum; Bergmann glia - nucleus[High] |
| HPA:0160052 | 0.0330731970199 | 1.0 | PPIG LUC7L2 SAP18 CCDC9 ACIN1 CLK2 NKTR | endometrium 1; glandular cells[>=Medium] |
| KEGG:03015 | 0.0411825364664 | 0.285714285714 | ACIN1 SAP18 | mRNA surveillance pathway |
| REAC:R-HSA-72203 | 0.0418111738628 | 0.428571428571 | ACIN1 SAP18 PPIG | Processing of Capped Intron-Containing Pre-mRNA |
| HPA:0490691 | 0.0470701914608 | 1.0 | PPIG LUC7L2 SAP18 CCDC9 ACIN1 CLK2 NKTR | smooth muscle; smooth muscle cells[>=Low] |
| HPA:0490000 | 0.0470701914608 | 1.0 | PPIG LUC7L2 SAP18 CCDC9 ACIN1 CLK2 NKTR | smooth muscle |
| HPA:0630221 | 0.0477522154514 | 1.0 | PPIG LUC7L2 SAP18 CCDC9 ACIN1 CLK2 NKTR | cervix; squamous epithelial cells[>=Low] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ACIN1 | SAP18 | 1.0 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | ||
| ACIN1 | LUC7L2 | 1.0 | 0.636 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| ACIN1 | CCDC9 | 0.999 | 0.169 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| CCDC9 | SAP18 | 0.998 |
structurally_consistent (P38919)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| CCDC9 | PPIG | 0.998 | 0.07 |
mutually_exclusive (P61326)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () |
| NKTR | PPIG | 0.997 | 0.296 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| ACIN1 | PPIG | 0.997 | 0.58 |
mutually_exclusive (P61326)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM fraction |
| NKTR | CCDC9 | 0.996 | 0.062 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| ACIN1 | NKTR | 0.996 | 0.362 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| NKTR | CLK2 | 0.995 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SAP18 | PPIG | 0.994 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM fraction | ||
| CCDC9 | LUC7L2 | 0.993 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| NKTR | SAP18 | 0.985 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| CCDC9 | CLK2 | 0.978 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only | |
| CLK2 | LUC7L2 | 0.977 | 0.12 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| ACIN1 | CLK2 | 0.975 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CLK2 | PPIG | 0.914 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only | |
| LUC7L2 | SAP18 | 0.907 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | ||
| NKTR | LUC7L2 | 0.648 | 0.146 | bioplex_WMM bioplex3_WMM WMM_only | |
| CLK2 | SAP18 | 0.628 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| LUC7L2 | PPIG | 0.538 | 0.276 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes