hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06221.1

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
PTPRK	Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)	5	UniProt NCBI
ITGB1	Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)	5	UniProt NCBI
ITGA8	Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]	5	UniProt NCBI
LGALS12	Galectin-12 (Gal-12) (Galectin-related inhibitor of proliferation)	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:2439	5.12628525639e-06	0.5	ITGB1 ITGA8	ITGA8-ITGB1 complex
WP:WP4823	0.00142851438729	0.5	ITGB1 ITGA8	Genes controlling nephrogenesis
WP:WP5053	0.0027493593259	0.5	ITGB1 ITGA8	Development of ureteric collection system
GO:0034678	0.0028092043205	0.5	ITGB1 ITGA8	integrin alpha8-beta1 complex
REAC:R-HSA-2129379	0.00415229579539	0.5	ITGB1 ITGA8	Molecules associated with elastic fibres
WP:WP2118	0.00434689671613	0.5	ITGB1 ITGA8	Arrhythmogenic right ventricular cardiomyopathy
KEGG:04512	0.00551283411821	0.5	ITGB1 ITGA8	ECM-receptor interaction
KEGG:05412	0.0056793701001	0.5	ITGB1 ITGA8	Arrhythmogenic right ventricular cardiomyopathy
REAC:R-HSA-1566948	0.00643909852192	0.5	ITGB1 ITGA8	Elastic fibre formation
KEGG:05410	0.00710024614077	0.5	ITGB1 ITGA8	Hypertrophic cardiomyopathy
KEGG:05414	0.00710024614077	0.5	ITGB1 ITGA8	Dilated cardiomyopathy
REAC:R-HSA-2173789	0.00837722051003	0.5	ITGB1 ITGA8	TGF-beta receptor signaling activates SMADs
WP:WP185	0.00883615359641	0.5	ITGB1 ITGA8	Integrin mediated cell adhesion
WP:WP4541	0.011545786253	0.5	ITGB1 ITGA8	Hippo Merlin signaling dysregulation
KEGG:04514	0.0133093129958	0.5	ITGB1 ITGA8	Cell adhesion molecules
REAC:R-HSA-3000178	0.0168610262513	0.5	ITGB1 ITGA8	ECM proteoglycans
REAC:R-HSA-216083	0.0199119958937	0.5	ITGB1 ITGA8	Integrin cell surface interactions
KEGG:03271	0.0244342250794	0.25	ITGB1	Virion - Rotavirus
CORUM:3058	0.0249718442456	0.25	ITGB1	ITGA11-ITGB1 complex
CORUM:3057	0.0249718442456	0.25	ITGB1	ITGA10-ITGB1 complex
CORUM:2426	0.0249718442456	0.25	ITGB1	ITGA4-ITGB1-THBS1 complex
CORUM:2432	0.0249718442456	0.25	ITGB1	ITGA2-ITGB1 complex
CORUM:3035	0.0249718442456	0.25	ITGB1	LAT2-ITGB1 complex
CORUM:2421	0.0249718442456	0.25	ITGB1	ITGA4-ITGB1-VCAM1 complex
CORUM:2431	0.0249718442456	0.25	ITGB1	ITGA2-ITGB1-COL6A3 complex
CORUM:2418	0.0249718442456	0.25	ITGB1	ITGA4-ITGB1 complex
CORUM:2413	0.0249718442456	0.25	ITGB1	ITGA6-ITGB1 complex
KEGG:04510	0.03673756538	0.5	ITGB1 ITGA8	Focal adhesion
WP:WP306	0.0374055211141	0.5	ITGB1 ITGA8	Focal adhesion
REAC:R-HSA-170834	0.0380580405855	0.5	ITGB1 ITGA8	Signaling by TGF-beta Receptor Complex
KEGG:04810	0.0466115978004	0.5	ITGB1 ITGA8	Regulation of actin cytoskeleton
CORUM:2972	0.049938562206	0.25	ITGB1	ITGA9-ITGB1-VEGFA complex
CORUM:2885	0.049938562206	0.25	ITGB1	ITGAV-ITGB1-SPP1 complex
CORUM:2971	0.049938562206	0.25	ITGB1	ITGA9-ITGB1-VEGFC complex
CORUM:2447	0.049938562206	0.25	ITGB1	ITGA9-ITGB1-ADAM12 complex
CORUM:3111	0.049938562206	0.25	ITGB1	ITGA9-ITGB1-SPP1 complex
CORUM:3059	0.049938562206	0.25	ITGB1	ITGA11-ITGB1-COL1A1 complex
CORUM:3104	0.049938562206	0.25	ITGB1	ITGB1-NRP1 complex
CORUM:3112	0.049938562206	0.25	ITGB1	ITGA5-ITGB1-SPP1 complex
CORUM:7012	0.049938562206	0.25	ITGB1	ITGB1-RACK1 complex
CORUM:2989	0.049938562206	0.25	ITGB1	ITGA9-ITGB1-ADAM8 complex
CORUM:2444	0.049938562206	0.25	ITGB1	ITGB1-ITGA9 complex
CORUM:2430	0.049938562206	0.25	ITGB1	ITGA2-ITGB1-CHAD complex
CORUM:2442	0.049938562206	0.25	ITGB1	ITGA9-ITGB1-VCAM1 complex
CORUM:2385	0.049938562206	0.25	ITGB1	ITGA5-ITGB4 complex
CORUM:2390	0.049938562206	0.25	ITGB1	CD98-LAT2-ITGB1 complex
CORUM:2397	0.049938562206	0.25	ITGB1	ITGA7-ITGB1-ITGB1BP3 complex
CORUM:2401	0.049938562206	0.25	ITGB1	ITGA3-ITGB1-THBS1 complex
CORUM:2406	0.049938562206	0.25	ITGB1	ITGA3-ITGB1 complex
CORUM:2411	0.049938562206	0.25	ITGB1	ITGA6-ITGB1-CD151 complex
CORUM:2417	0.049938562206	0.25	ITGB1	ITGA4-ITGB1-EMILIN1 complex
CORUM:2419	0.049938562206	0.25	ITGB1	ITGA4-ITGB1-CD81 complex
CORUM:2420	0.049938562206	0.25	ITGB1	ITGA4-ITGB1-CD53 complex
CORUM:2422	0.049938562206	0.25	ITGB1	ITGA4-ITGB1-JAM2 complex
CORUM:2423	0.049938562206	0.25	ITGB1	ITGA4-ITGB1-CD47 complex
CORUM:2424	0.049938562206	0.25	ITGB1	ITGA4-ITGB1-CD63 complex
CORUM:2429	0.049938562206	0.25	ITGB1	ITGA2-ITGB1-CD47 complex
CORUM:2434	0.049938562206	0.25	ITGB1	ITGA1-ITGB1-COL6A3 complex
CORUM:2435	0.049938562206	0.25	ITGB1	ITGA1-ITGB1-PTPN2 complex
CORUM:2436	0.049938562206	0.25	ITGB1	ITGAV-ITGB1 complex
CORUM:2437	0.049938562206	0.25	ITGB1	ITGA6-ITGB1-CYR61 complex
CORUM:2443	0.049938562206	0.25	ITGB1	ITGA9-ITGB1-TNC complex
CORUM:2428	0.049938562206	0.25	ITGB1	ITGA4-ITGB1-THBS2 complex

Edges

Protein 1	Protein 2	Score	Evidence
ITGB1	ITGA8	0.989	bioplex3_HEK293 bioplex_WMM bioplex3_WMM fraction
LGALS12	PTPRK	0.98	bioplex3_WMM bioplex3_HCT116 WMM_only
ITGB1	PTPRK	0.97	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
ITGA8	PTPRK	0.957	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
ITGB1	LGALS12	0.013	bioplex3_HCT116 WMM_only

Related Complexes

Genename	Complexes
PTPRK	huMAP3_06221.1 huMAP3_06308.1 huMAP3_07830.1 huMAP3_08084.1 huMAP3_09105.1 huMAP3_10503.1 huMAP3_10980.1
ITGB1	huMAP3_00444.1 huMAP3_05336.1 huMAP3_05466.1 huMAP3_06221.1 huMAP3_06815.1 huMAP3_06955.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10980.1
ITGA8	huMAP3_00444.1 huMAP3_03217.1 huMAP3_05336.1 huMAP3_05466.1 huMAP3_06221.1 huMAP3_06815.1 huMAP3_08084.1 huMAP3_10503.1 huMAP3_10980.1
LGALS12	huMAP3_02380.1 huMAP3_03187.1 huMAP3_06221.1 huMAP3_06954.1 huMAP3_09632.1 huMAP3_09917.1 huMAP3_10881.1 huMAP3_12342.1 huMAP3_12962.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06221.1