hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06230.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AP3B1 | AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) | 5 | UniProt NCBI |
| AP3S1 | AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a) | 5 | UniProt NCBI |
| AP3D1 | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | 5 | UniProt NCBI |
| AP3B2 | AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:59 | 1.68055125058e-12 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | AP3 adaptor complex |
| CORUM:652 | 6.55414987728e-11 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | AP3-BLOC1 complex |
| GO:0035654 | 9.2094208532e-10 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | clathrin-coated vesicle cargo loading, AP-3-mediated |
| GO:0035652 | 9.2094208532e-10 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | clathrin-coated vesicle cargo loading |
| GO:0030123 | 3.31539150715e-09 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | AP-3 adaptor complex |
| GO:0048490 | 8.0516650888e-08 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | anterograde synaptic vesicle transport |
| GO:0099514 | 8.0516650888e-08 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | synaptic vesicle cytoskeletal transport |
| GO:0099517 | 8.0516650888e-08 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | synaptic vesicle transport along microtubule |
| KEGG:04142 | 2.13288072552e-07 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | Lysosome |
| GO:0035459 | 8.27926934703e-07 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | vesicle cargo loading |
| GO:0048489 | 9.46202211089e-07 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | synaptic vesicle transport |
| GO:0030119 | 1.37772935964e-06 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | AP-type membrane coat adaptor complex |
| WP:WP5408 | 1.73107546211e-06 | 0.75 | AP3D1 AP3S1 AP3B2 | 15q25 copy number variation |
| GO:0097479 | 1.737817715e-06 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | synaptic vesicle localization |
| GO:0047496 | 2.6646801423e-06 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | vesicle transport along microtubule |
| GO:0008089 | 2.94517278885e-06 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | anterograde axonal transport |
| GO:0016183 | 3.84440695359e-06 | 0.75 | AP3D1 AP3S1 AP3B2 | synaptic vesicle coating |
| CORUM:2308 | 5.12628525639e-06 | 0.5 | AP3D1 AP3S1 | AP3D1-AP3S1 complex |
| GO:0098930 | 8.32139586928e-06 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | axonal transport |
| GO:0008088 | 1.28309598221e-05 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | axo-dendritic transport |
| GO:0070142 | 1.34540429244e-05 | 0.75 | AP3D1 AP3S1 AP3B2 | synaptic vesicle budding |
| GO:0016185 | 1.34540429244e-05 | 0.75 | AP3D1 AP3S1 AP3B2 | synaptic vesicle budding from presynaptic endocytic zone membrane |
| GO:0099518 | 1.56735133501e-05 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | vesicle cytoskeletal trafficking |
| GO:0072384 | 2.55662732306e-05 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | organelle transport along microtubule |
| GO:0048475 | 5.85691538001e-05 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | coated membrane |
| GO:0030117 | 5.85691538001e-05 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | membrane coat |
| GO:1903232 | 0.000313494264121 | 0.75 | AP3B1 AP3S1 AP3D1 | melanosome assembly |
| HP:0011125 | 0.000334337547576 | 0.5 | AP3B1 AP3D1 | Abnormality of dermal melanosomes |
| GO:0010970 | 0.000358741938032 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | transport along microtubule |
| GO:0060155 | 0.000510886175237 | 0.75 | AP3B1 AP3S1 AP3D1 | platelet dense granule organization |
| GO:0099111 | 0.000577505678494 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | microtubule-based transport |
| GO:0051650 | 0.000842501764145 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | establishment of vesicle localization |
| GO:0030705 | 0.000948358662764 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | cytoskeleton-dependent intracellular transport |
| GO:0051648 | 0.00097067298424 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | vesicle localization |
| GO:0006901 | 0.0025122894873 | 0.75 | AP3D1 AP3S1 AP3B2 | vesicle coating |
| GO:0048753 | 0.00274053853655 | 0.75 | AP3B1 AP3S1 AP3D1 | pigment granule organization |
| GO:0032438 | 0.00274053853655 | 0.75 | AP3B1 AP3S1 AP3D1 | melanosome organization |
| GO:0033363 | 0.00323764786551 | 0.75 | AP3B1 AP3S1 AP3D1 | secretory granule organization |
| HP:0001022 | 0.00400802433742 | 0.5 | AP3B1 AP3D1 | Albinism |
| GO:0048488 | 0.00544401218013 | 0.75 | AP3D1 AP3S1 AP3B2 | synaptic vesicle endocytosis |
| GO:0140238 | 0.00544401218013 | 0.75 | AP3D1 AP3S1 AP3B2 | presynaptic endocytosis |
| GO:0005769 | 0.00569790407237 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | early endosome |
| GO:0007018 | 0.00578326593113 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | microtubule-based movement |
| GO:0016050 | 0.00669062030536 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | vesicle organization |
| HP:0001107 | 0.00701084122037 | 0.5 | AP3B1 AP3D1 | Ocular albinism |
| GO:0036465 | 0.00951168180783 | 0.75 | AP3D1 AP3S1 AP3B2 | synaptic vesicle recycling |
| GO:0033059 | 0.0100599149475 | 0.75 | AP3B1 AP3S1 AP3D1 | cellular pigmentation |
| HP:0007513 | 0.0108451581837 | 0.5 | AP3B1 AP3D1 | Generalized hypopigmentation |
| REAC:R-HSA-432722 | 0.0146019089592 | 0.5 | AP3B1 AP3S1 | Golgi Associated Vesicle Biogenesis |
| GO:0051656 | 0.0195656568104 | 1.0 | AP3B1 AP3B2 AP3S1 AP3D1 | establishment of organelle localization |
| GO:0006900 | 0.0228491864842 | 0.75 | AP3D1 AP3S1 AP3B2 | vesicle budding from membrane |
| GO:0043473 | 0.0238272099283 | 0.75 | AP3B1 AP3S1 AP3D1 | pigmentation |
| REAC:R-HSA-199992 | 0.0246065982605 | 0.5 | AP3B1 AP3S1 | trans-Golgi Network Vesicle Budding |
| HP:0007730 | 0.036003514982 | 0.5 | AP3B1 AP3D1 | Iris hypopigmentation |
| CORUM:2307 | 0.049938562206 | 0.25 | AP3D1 | AP3D1-AP3S2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| AP3S1 | AP3B2 | 1.0 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| AP3B1 | AP3S1 | 1.0 | 0.262 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| AP3S1 | AP3D1 | 0.999 | 0.482 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| AP3B1 | AP3D1 | 0.993 | 0.806 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| AP3B1 | AP3B2 | 0.991 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| AP3D1 | AP3B2 | 0.921 | 0.038 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes