hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06243.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GRB2 | Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) | 5 | UniProt NCBI |
| C16orf96 | Uncharacterized protein C16orf96 | 2 | UniProt NCBI |
| CBL | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | 5 | UniProt NCBI |
| SOS2 | Son of sevenless homolog 2 (SOS-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2534 | 5.12628525639e-06 | 0.5 | GRB2 CBL | Cbl-SLP-76-Grb2 complex, Fc receptor gamma-R1 stimulated |
| CORUM:2535 | 5.12628525639e-06 | 0.5 | GRB2 CBL | SLP-76-Cbl-Grb2-Shc complex, Fc receptor gamma-R1 stimulated |
| WP:WP4205 | 1.01988257731e-05 | 0.75 | GRB2 SOS2 CBL | MET in type 1 papillary renal cell carcinoma |
| CORUM:2542 | 1.53774525569e-05 | 0.5 | GRB2 CBL | EGFR-CBL-GRB2 complex |
| KEGG:05220 | 2.21720662311e-05 | 0.75 | GRB2 SOS2 CBL | Chronic myeloid leukemia |
| KEGG:04012 | 2.40425716137e-05 | 0.75 | GRB2 SOS2 CBL | ErbB signaling pathway |
| WP:WP673 | 2.97022868077e-05 | 0.75 | GRB2 SOS2 CBL | ErbB signaling pathway |
| CORUM:2529 | 5.12488211613e-05 | 0.5 | GRB2 CBL | LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated |
| CORUM:2480 | 0.000107602882996 | 0.5 | GRB2 CBL | CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) |
| KEGG:04910 | 0.000111034102003 | 0.75 | GRB2 SOS2 CBL | Insulin signaling pathway |
| WP:WP481 | 0.000165592798419 | 0.75 | GRB2 SOS2 CBL | Insulin signaling |
| WP:WP437 | 0.000169107306289 | 0.75 | GRB2 SOS2 CBL | EGF EGFR signaling pathway |
| KEGG:05205 | 0.000336138721134 | 0.75 | GRB2 SOS2 CBL | Proteoglycans in cancer |
| REAC:R-HSA-8983432 | 0.000798898068561 | 0.5 | GRB2 SOS2 | Interleukin-15 signaling |
| WP:WP422 | 0.000894348084449 | 0.5 | GRB2 SOS2 | MAPK cascade |
| WP:WP5365 | 0.000894348084449 | 0.5 | GRB2 CBL | 4p16 3 copy number variation |
| WP:WP49 | 0.0013446069671 | 0.5 | GRB2 CBL | IL 2 signaling pathway |
| WP:WP4535 | 0.00178944501344 | 0.5 | GRB2 SOS2 | Envelope proteins and their potential roles in EDMD physiopathology |
| WP:WP286 | 0.002190823719 | 0.5 | GRB2 CBL | IL 3 signaling pathway |
| WP:WP395 | 0.0027493593259 | 0.5 | GRB2 CBL | IL 4 signaling pathway |
| REAC:R-HSA-9682385 | 0.00282403231951 | 0.5 | GRB2 CBL | FLT3 signaling in disease |
| WP:WP3863 | 0.00299043061896 | 0.5 | GRB2 CBL | T cell antigen receptor TCR pathway during Staphylococcus aureus infection |
| WP:WP304 | 0.00324158330579 | 0.5 | GRB2 CBL | Kit receptor signaling pathway |
| KEGG:05213 | 0.00331074310373 | 0.5 | GRB2 SOS2 | Endometrial cancer |
| KEGG:04664 | 0.0034402616107 | 0.5 | GRB2 SOS2 | Fc epsilon RI signaling pathway |
| HP:0011381 | 0.00350734148159 | 0.5 | CBL SOS2 | Aplasia of the semicircular canal |
| WP:WP4155 | 0.00405547408869 | 0.5 | GRB2 SOS2 | Endometrial cancer |
| KEGG:05221 | 0.00426927356048 | 0.5 | GRB2 SOS2 | Acute myeloid leukemia |
| WP:WP5293 | 0.00434689671613 | 0.5 | GRB2 SOS2 | Acute myeloid leukemia |
| WP:WP3680 | 0.00434689671613 | 0.5 | GRB2 CBL | Physico chemical features and toxicity associated pathways |
| WP:WP4685 | 0.00449637847065 | 0.5 | GRB2 SOS2 | Melanoma |
| WP:WP69 | 0.00464837292584 | 0.5 | GRB2 CBL | T cell receptor signaling pathway |
| KEGG:04917 | 0.00471711368352 | 0.5 | GRB2 SOS2 | Prolactin signaling pathway |
| KEGG:05200 | 0.0049271234807 | 0.75 | GRB2 SOS2 CBL | Pathways in cancer |
| HP:0012209 | 0.0051092979876 | 0.5 | CBL SOS2 | Juvenile myelomonocytic leukemia |
| HP:0011380 | 0.0051092979876 | 0.5 | CBL SOS2 | Abnormal semicircular canal morphology |
| KEGG:05211 | 0.00518715200321 | 0.5 | GRB2 SOS2 | Renal cell carcinoma |
| REAC:R-HSA-451927 | 0.00539805716719 | 0.5 | GRB2 SOS2 | Interleukin-2 family signaling |
| WP:WP2037 | 0.00561306746582 | 0.5 | GRB2 CBL | Prolactin signaling pathway |
| WP:WP4255 | 0.00561306746582 | 0.5 | GRB2 SOS2 | Non small cell lung cancer |
| KEGG:05214 | 0.0056793701001 | 0.5 | GRB2 SOS2 | Glioma |
| KEGG:05223 | 0.0056793701001 | 0.5 | GRB2 SOS2 | Non-small cell lung cancer |
| KEGG:04662 | 0.0056793701001 | 0.5 | GRB2 SOS2 | B cell receptor signaling pathway |
| KEGG:04912 | 0.0056793701001 | 0.5 | GRB2 SOS2 | GnRH signaling pathway |
| KEGG:04540 | 0.00619374956043 | 0.5 | GRB2 SOS2 | Gap junction |
| KEGG:01521 | 0.00673027197618 | 0.5 | GRB2 SOS2 | EGFR tyrosine kinase inhibitor resistance |
| HP:0012569 | 0.00701084122037 | 0.5 | CBL SOS2 | Delayed menarche |
| WP:WP23 | 0.00722934152515 | 0.5 | GRB2 CBL | B cell receptor signaling pathway |
| WP:WP2261 | 0.00742144474402 | 0.5 | GRB2 CBL | Glioblastoma signaling pathways |
| KEGG:05210 | 0.00748004798883 | 0.5 | GRB2 SOS2 | Colorectal cancer |
| WP:WP4806 | 0.00781315318354 | 0.5 | GRB2 SOS2 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:01522 | 0.00826911293642 | 0.5 | GRB2 SOS2 | Endocrine resistance |
| KEGG:05231 | 0.00847251296121 | 0.5 | GRB2 SOS2 | Choline metabolism in cancer |
| KEGG:05215 | 0.00996493530849 | 0.5 | GRB2 SOS2 | Prostate cancer |
| WP:WP4321 | 0.0103731686562 | 0.5 | GRB2 SOS2 | Thermogenesis |
| KEGG:04915 | 0.0104133784038 | 0.5 | GRB2 SOS2 | Estrogen signaling pathway |
| HP:0011376 | 0.0108451581837 | 0.5 | CBL SOS2 | Abnormal morphology of the vestibule of the inner ear |
| HP:0012324 | 0.0117117011059 | 0.5 | CBL SOS2 | Myeloid leukemia |
| KEGG:04935 | 0.0123049375309 | 0.5 | GRB2 SOS2 | Growth hormone synthesis, secretion and action |
| KEGG:04722 | 0.0123049375309 | 0.5 | GRB2 SOS2 | Neurotrophin signaling pathway |
| WP:WP710 | 0.0127805971611 | 0.5 | GRB2 SOS2 | DNA damage response only ATM dependent |
| KEGG:04660 | 0.0130545606238 | 0.5 | GRB2 SOS2 | T cell receptor signaling pathway |
| REAC:R-HSA-449147 | 0.0141224671799 | 0.75 | GRB2 SOS2 CBL | Signaling by Interleukins |
| KEGG:04926 | 0.014352694406 | 0.5 | GRB2 SOS2 | Relaxin signaling pathway |
| KEGG:04650 | 0.014619629343 | 0.5 | GRB2 SOS2 | Natural killer cell mediated cytotoxicity |
| KEGG:04068 | 0.0157117070582 | 0.5 | GRB2 SOS2 | FoxO signaling pathway |
| WP:WP3915 | 0.0162815495406 | 0.5 | CBL SOS2 | Angiopoietin like protein 8 regulatory pathway |
| KEGG:04072 | 0.0165563012031 | 0.5 | GRB2 SOS2 | Phospholipase D signaling pathway |
| WP:WP3929 | 0.0183400443465 | 0.5 | GRB2 SOS2 | Chemokine signaling pathway |
| HP:0010318 | 0.018706736024 | 0.5 | CBL SOS2 | Aplasia/Hypoplasia of the abdominal wall musculature |
| KEGG:05224 | 0.0198400959038 | 0.5 | GRB2 SOS2 | Breast cancer |
| KEGG:05160 | 0.0211069184789 | 0.5 | GRB2 SOS2 | Hepatitis C |
| KEGG:05226 | 0.0211069184789 | 0.5 | GRB2 SOS2 | Gastric cancer |
| KEGG:04630 | 0.0211069184789 | 0.5 | GRB2 SOS2 | JAK-STAT signaling pathway |
| WP:WP4239 | 0.0218193051527 | 0.5 | GRB2 SOS2 | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP4262 | 0.0221503925292 | 0.5 | GRB2 SOS2 | Breast cancer pathway |
| WP:WP4666 | 0.023499356813 | 0.5 | GRB2 SOS2 | Hepatitis B infection |
| KEGG:04062 | 0.0237566589162 | 0.5 | GRB2 SOS2 | Chemokine signaling pathway |
| CORUM:2892 | 0.0249718442456 | 0.25 | GRB2 | BCR-ABL (p185 fusion protein)-GRB2 complex |
| CORUM:2895 | 0.0249718442456 | 0.25 | GRB2 | SHC-GRB2 complex |
| CORUM:2540 | 0.0249718442456 | 0.25 | GRB2 | BCR-ABL (p210 fusion protein)-GRB2 complex |
| CORUM:3096 | 0.0249718442456 | 0.25 | GRB2 | ITGA6-ITGB4-SHC1-GRB2 complex |
| CORUM:5713 | 0.0249718442456 | 0.25 | CBL | SH3P2/OSTF1-CBL-SRC complex |
| KEGG:04150 | 0.0269222811984 | 0.5 | GRB2 SOS2 | mTOR signaling pathway |
| KEGG:05161 | 0.0269222811984 | 0.5 | GRB2 SOS2 | Hepatitis B |
| KEGG:05206 | 0.0269222811984 | 0.5 | GRB2 SOS2 | MicroRNAs in cancer |
| WP:WP4223 | 0.0270438297073 | 0.5 | GRB2 SOS2 | Ras signaling |
| KEGG:05034 | 0.0272860662684 | 0.5 | GRB2 SOS2 | Alcoholism |
| HP:0000391 | 0.03008608933 | 0.5 | CBL SOS2 | Thickened helices |
| KEGG:05225 | 0.0310562109 | 0.5 | GRB2 SOS2 | Hepatocellular carcinoma |
| KEGG:05207 | 0.0326315237827 | 0.5 | GRB2 SOS2 | Chemical carcinogenesis - receptor activation |
| HP:0000476 | 0.0329787201379 | 0.5 | CBL SOS2 | Cystic hygroma |
| HP:0011869 | 0.036003514982 | 0.5 | CBL SOS2 | Abnormal platelet function |
| KEGG:04510 | 0.03673756538 | 0.5 | GRB2 SOS2 | Focal adhesion |
| HP:0000474 | 0.0391604009626 | 0.5 | CBL SOS2 | Thickened nuchal skin fold |
| HP:0000635 | 0.0391604009626 | 0.5 | CBL SOS2 | Blue irides |
| KEGG:04014 | 0.0415303647194 | 0.5 | GRB2 SOS2 | Ras signaling pathway |
| KEGG:05163 | 0.0451972531521 | 0.5 | GRB2 SOS2 | Human cytomegalovirus infection |
| HP:0002208 | 0.0458701548093 | 0.5 | CBL SOS2 | Coarse hair |
| HP:0010991 | 0.0476300363671 | 0.5 | CBL SOS2 | Abnormal morphology of the abdominal musculature |
| CORUM:3175 | 0.049938562206 | 0.25 | CBL | CIN85-CBL complex |
| CORUM:2536 | 0.049938562206 | 0.25 | GRB2 | PLC-gamma-2-SLP-76-Lyn-Grb2 complex |
| CORUM:2893 | 0.049938562206 | 0.25 | GRB2 | BCR-ABL (p210 fusion protein)-GRB2-SOS1 complex |
| CORUM:2917 | 0.049938562206 | 0.25 | GRB2 | GRB2-SOS1 complex |
| CORUM:2957 | 0.049938562206 | 0.25 | GRB2 | LAT-GRB2 complex, Fyn-mLck(KA) or Syk kinase activated |
| CORUM:5720 | 0.049938562206 | 0.25 | CBL | CIN85-CBL complex |
| CORUM:5709 | 0.049938562206 | 0.25 | CBL | ArgBP2a-CBL-PTK2B complex |
| CORUM:3186 | 0.049938562206 | 0.25 | GRB2 | GRB2-SHP-2 complex, PDGF stimulated |
| CORUM:3144 | 0.049938562206 | 0.25 | GRB2 | GRB2-SOS1 complex |
| KEGG:05208 | 0.049994875911 | 0.5 | GRB2 SOS2 | Chemical carcinogenesis - reactive oxygen species |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SOS2 | GRB2 | 1.0 | 0.192 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CBL | GRB2 | 0.972 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| C16orf96 | GRB2 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| C16orf96 | SOS2 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | |
| CBL | C16orf96 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | |
| CBL | SOS2 | 0.304 | 0.182 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes