hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06250.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIGS | GPI transamidase component PIG-S (Phosphatidylinositol-glycan biosynthesis class S protein) | 5 | UniProt NCBI |
| LYPD3 | Ly6/PLAUR domain-containing protein 3 (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4) | 5 | UniProt NCBI |
| DNAJC22 | DnaJ homolog subfamily C member 22 | 2 | UniProt NCBI |
| TMEM245 | Transmembrane protein 245 (Protein CG-2) | 4 | UniProt NCBI |
| ULBP2 | UL16-binding protein 2 (ALCAN-alpha) (NKG2D ligand 2) (N2DL-2) (NKG2DL2) (Retinoic acid early transcript 1H) | 5 | UniProt NCBI |
| PIGU | Phosphatidylinositol glycan anchor biosynthesis class U protein (Cell division cycle protein 91-like 1) (Protein CDC91-like 1) (GPI transamidase component PIG-U) | 5 | UniProt NCBI |
| TMC4 | Transmembrane channel-like protein 4 | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-163125 | 2.39259094536e-06 | 0.571428571429 | ULBP2 PIGU PIGS LYPD3 | Post-translational modification: synthesis of GPI-anchored proteins |
| CORUM:994 | 0.000205125012531 | 0.285714285714 | PIGU PIGS | GAA1-GPI8-PIGT-PIG-PIGS complex |
| REAC:R-HSA-162791 | 0.000799384186586 | 0.285714285714 | PIGU PIGS | Attachment of GPI anchor to uPAR |
| KEGG:00563 | 0.00214596338191 | 0.285714285714 | PIGU PIGS | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LYPD3 | DNAJC22 | 0.999 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PIGS | PIGU | 0.998 | 0.36 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM |
| LYPD3 | TMEM245 | 0.998 | 0.108 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
| TMC4 | LYPD3 | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LYPD3 | PIGS | 0.992 | 0.072 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
| ULBP2 | LYPD3 | 0.975 | 0.104 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| LYPD3 | PIGU | 0.97 | 0.088 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
| TMC4 | DNAJC22 | 0.902 | bioplex3_WMM WMM_only | |
| PIGS | TMEM245 | 0.839 | 0.078 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| PIGU | TMEM245 | 0.836 | 0.016 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| TMC4 | PIGS | 0.769 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| TMC4 | PIGU | 0.597 | bioplex3_WMM WMM_only | |
| ULBP2 | DNAJC22 | 0.355 | bioplex3_WMM WMM_only | |
| DNAJC22 | TMEM245 | 0.343 | bioplex3_WMM WMM_only | |
| TMC4 | ULBP2 | 0.243 | bioplex3_WMM WMM_only | |
| TMC4 | TMEM245 | 0.22 | bioplex3_WMM WMM_only | |
| DNAJC22 | PIGS | 0.154 | bioplex3_WMM WMM_only | |
| DNAJC22 | PIGU | 0.129 | bioplex3_WMM WMM_only | |
| ULBP2 | TMEM245 | 0.128 | 0.046 | bioplex3_WMM WMM_only |
| ULBP2 | PIGS | 0.077 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only |
| ULBP2 | PIGU | 0.043 | 0.1 | bioplex3_WMM WMM_only |
Related Complexes