hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06251.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IRF3 | Interferon regulatory factor 3 (IRF-3) | 5 | UniProt NCBI |
| USP19 | Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9) | 5 | UniProt NCBI |
| PSEN2 | Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5187 | 0.0496447587094 | 0.333333333333 | IRF3 | mRNA vaccine activation of dendritic cell and induction of IFN 1 |
| CORUM:299 | 0.0499402709677 | 0.333333333333 | IRF3 | IRF3-CBP complex |
| CORUM:467 | 0.0499402709677 | 0.333333333333 | PSEN2 | Gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN) |
| CORUM:7575 | 0.0499402709677 | 0.333333333333 | PSEN2 | APP-PSEN2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| USP19 | IRF3 | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IRF3 | PSEN2 | 0.965 | 0.1 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| USP19 | PSEN2 | 0.002 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes