hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06254.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CXCL1 | Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)] | 5 | UniProt NCBI |
| BIRC3 | Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1) | 5 | UniProt NCBI |
| HTRA2 | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | 5 | UniProt NCBI |
| DIABLO | Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form] | 5 | UniProt NCBI |
| TANK | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | 5 | UniProt NCBI |
| TRAF2 | TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) | 5 | UniProt NCBI |
| TBK1 | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | 5 | UniProt NCBI |
| TRAF1 | TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) | 5 | UniProt NCBI |
| IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP231 | 2.272578538e-10 | 0.666666666667 | TANK TRAF1 TRAF2 TBK1 BIRC3 DIABLO | TNF alpha signaling pathway |
| KEGG:04621 | 3.71439173045e-09 | 0.666666666667 | IKBKE TANK CXCL1 TRAF2 TBK1 BIRC3 | NOD-like receptor signaling pathway |
| REAC:R-HSA-5357905 | 5.78771076455e-09 | 0.555555555556 | BIRC3 IKBKE TRAF1 TRAF2 TBK1 | Regulation of TNFR1 signaling |
| REAC:R-HSA-75893 | 1.52620946243e-08 | 0.555555555556 | BIRC3 IKBKE TRAF1 TRAF2 TBK1 | TNF signaling |
| REAC:R-HSA-5357786 | 1.66051543107e-07 | 0.444444444444 | BIRC3 IKBKE TRAF2 TBK1 | TNFR1-induced proapoptotic signaling |
| KEGG:04210 | 2.12946846369e-07 | 0.555555555556 | BIRC3 TRAF1 HTRA2 TRAF2 DIABLO | Apoptosis |
| GO:0071345 | 2.39805056915e-07 | 0.888888888889 | TANK IKBKE CXCL1 HTRA2 TRAF2 TBK1 BIRC3 TRAF1 | cellular response to cytokine stimulus |
| REAC:R-HSA-168164 | 2.45186016854e-07 | 0.555555555556 | BIRC3 IKBKE TBK1 TRAF2 TANK | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166166 | 2.73883240123e-07 | 0.555555555556 | BIRC3 IKBKE TBK1 TRAF2 TANK | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 2.73883240123e-07 | 0.555555555556 | BIRC3 IKBKE TBK1 TRAF2 TANK | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-933541 | 3.70646453728e-07 | 0.444444444444 | TANK IKBKE TRAF2 TBK1 | TRAF6 mediated IRF7 activation |
| GO:0034097 | 6.17693963641e-07 | 0.888888888889 | TANK IKBKE CXCL1 HTRA2 TRAF2 TBK1 BIRC3 TRAF1 | response to cytokine |
| CORUM:5212 | 7.32877958003e-07 | 0.333333333333 | TANK TRAF2 TBK1 | Kinase maturation complex 2 |
| REAC:R-HSA-166016 | 1.13086406247e-06 | 0.555555555556 | BIRC3 IKBKE TBK1 TRAF2 TANK | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-73887 | 1.32936452512e-06 | 0.555555555556 | BIRC3 IKBKE TRAF1 TRAF2 TBK1 | Death Receptor Signaling |
| WP:WP5039 | 1.61647408699e-06 | 0.444444444444 | TANK TBK1 CXCL1 TRAF2 | SARS CoV 2 innate immunity evasion and cell specific immune response |
| KEGG:05417 | 1.64080762858e-06 | 0.555555555556 | TANK IKBKE TBK1 CXCL1 TRAF2 | Lipid and atherosclerosis |
| WP:WP3865 | 1.88726958983e-06 | 0.444444444444 | TANK IKBKE TRAF2 TBK1 | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04622 | 2.23197494441e-06 | 0.444444444444 | TANK IKBKE TRAF2 TBK1 | RIG-I-like receptor signaling pathway |
| REAC:R-HSA-168898 | 2.33488700563e-06 | 0.555555555556 | BIRC3 IKBKE TBK1 TRAF2 TANK | Toll-like Receptor Cascades |
| KEGG:04657 | 4.44661746921e-06 | 0.444444444444 | TBK1 IKBKE CXCL1 TRAF2 | IL-17 signaling pathway |
| GO:0019221 | 4.86535950405e-06 | 0.777777777778 | TANK IKBKE CXCL1 TRAF1 TBK1 BIRC3 TRAF2 | cytokine-mediated signaling pathway |
| KEGG:04064 | 5.19250512427e-06 | 0.444444444444 | BIRC3 TRAF1 CXCL1 TRAF2 | NF-kappa B signaling pathway |
| WP:WP254 | 6.46155621312e-06 | 0.444444444444 | BIRC3 TRAF1 DIABLO TRAF2 | Apoptosis |
| REAC:R-HSA-9013973 | 8.39516773096e-06 | 0.333333333333 | TANK IKBKE TBK1 | TICAM1-dependent activation of IRF3/IRF7 |
| KEGG:04668 | 1.0408935525e-05 | 0.444444444444 | BIRC3 TRAF1 CXCL1 TRAF2 | TNF signaling pathway |
| REAC:R-HSA-936964 | 1.38816297355e-05 | 0.333333333333 | TANK IKBKE TBK1 | Activation of IRF3, IRF7 mediated by TBK1, IKBKE |
| REAC:R-HSA-168928 | 1.87298045635e-05 | 0.444444444444 | TANK IKBKE TRAF2 TBK1 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| KEGG:04215 | 2.95927970333e-05 | 0.333333333333 | BIRC3 HTRA2 DIABLO | Apoptosis - multiple species |
| GO:0043122 | 3.61752507345e-05 | 0.666666666667 | IKBKE TANK TRAF2 TBK1 BIRC3 TRAF1 | regulation of canonical NF-kappaB signal transduction |
| GO:0007249 | 6.71206523496e-05 | 0.666666666667 | IKBKE TANK TRAF2 TBK1 BIRC3 TRAF1 | canonical NF-kappaB signal transduction |
| CORUM:5210 | 8.20609246787e-05 | 0.222222222222 | TANK TRAF2 | TANK-TRAF2-TRAF3 complex |
| KEGG:05167 | 0.000102605545806 | 0.444444444444 | TBK1 IKBKE CXCL1 TRAF2 | Kaposi sarcoma-associated herpesvirus infection |
| WP:WP2036 | 0.000104134373519 | 0.333333333333 | BIRC3 TRAF2 TRAF1 | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| REAC:R-HSA-5357956 | 0.000188109751173 | 0.333333333333 | BIRC3 TRAF2 TRAF1 | TNFR1-induced NF-kappa-B signaling pathway |
| GO:0007166 | 0.000207060011584 | 1.0 | TANK IKBKE TRAF1 CXCL1 HTRA2 DIABLO TBK1 BIRC3 TRAF2 | cell surface receptor signaling pathway |
| GO:0035556 | 0.000330095547237 | 1.0 | TANK IKBKE TRAF1 CXCL1 HTRA2 DIABLO TBK1 BIRC3 TRAF2 | intracellular signal transduction |
| GO:0071310 | 0.000404536983205 | 0.888888888889 | TANK IKBKE CXCL1 HTRA2 TRAF2 TBK1 BIRC3 TRAF1 | cellular response to organic substance |
| KEGG:05222 | 0.000814374186211 | 0.333333333333 | BIRC3 TRAF2 TRAF1 | Small cell lung cancer |
| REAC:R-HSA-168249 | 0.000840607349289 | 0.666666666667 | IKBKE TANK CXCL1 TRAF2 TBK1 BIRC3 | Innate Immune System |
| WP:WP5116 | 0.000859567015467 | 0.222222222222 | TBK1 IKBKE | SARS CoV 2 B 1 1 7 variant antagonises innate immune activation |
| WP:WP1772 | 0.0010952544073 | 0.333333333333 | BIRC3 HTRA2 DIABLO | Apoptosis modulation and signaling |
| GO:0035631 | 0.00132894467527 | 0.333333333333 | HTRA2 TRAF2 DIABLO | CD40 receptor complex |
| WP:WP4658 | 0.00162941812401 | 0.333333333333 | BIRC3 TRAF2 TRAF1 | Small cell lung cancer |
| KEGG:05168 | 0.00225499097545 | 0.444444444444 | BIRC3 IKBKE TRAF2 TBK1 | Herpes simplex virus 1 infection |
| KEGG:04936 | 0.00243900744737 | 0.333333333333 | TBK1 CXCL1 IKBKE | Alcoholic liver disease |
| CORUM:6344 | 0.00248045060598 | 0.222222222222 | BIRC3 TRAF2 | TNF-R1-associated signaling complex |
| GO:0010033 | 0.00270929678435 | 0.888888888889 | TANK IKBKE CXCL1 HTRA2 TRAF2 TBK1 BIRC3 TRAF1 | response to organic substance |
| WP:WP5182 | 0.00278824374686 | 0.222222222222 | BIRC3 TRAF2 | Pro survival signaling of neuroprotectin D1 |
| KEGG:05160 | 0.00287336310275 | 0.333333333333 | TBK1 TRAF2 IKBKE | Hepatitis C |
| KEGG:05022 | 0.00361080852902 | 0.444444444444 | TANK TBK1 HTRA2 TRAF2 | Pathways of neurodegeneration - multiple diseases |
| REAC:R-HSA-5676594 | 0.00438093013445 | 0.222222222222 | BIRC3 TRAF2 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
| WP:WP4961 | 0.00468193988771 | 0.222222222222 | TBK1 IKBKE | STING pathway in Kawasaki like disease and COVID 19 |
| WP:WP2507 | 0.0052310849594 | 0.222222222222 | HTRA2 DIABLO | Nanomaterial induced apoptosis |
| GO:0070887 | 0.00682592290479 | 0.888888888889 | TANK IKBKE CXCL1 HTRA2 TRAF2 TBK1 BIRC3 TRAF1 | cellular response to chemical stimulus |
| REAC:R-HSA-918233 | 0.00724150508664 | 0.222222222222 | TBK1 IKBKE | TRAF3-dependent IRF activation pathway |
| KEGG:05169 | 0.00738827422101 | 0.333333333333 | TBK1 TRAF2 IKBKE | Epstein-Barr virus infection |
| WP:WP4868 | 0.00772967459081 | 0.222222222222 | TBK1 IKBKE | Type I interferon induction and signaling during SARS CoV 2 infection |
| WP:WP3851 | 0.00915976746587 | 0.222222222222 | TBK1 IKBKE | TLR4 signaling and tolerance |
| WP:WP4950 | 0.00991991165725 | 0.222222222222 | TRAF2 TRAF1 | 16p11 2 distal deletion syndrome |
| WP:WP3858 | 0.0107100822997 | 0.222222222222 | TBK1 IKBKE | Toll like receptor signaling related to MyD88 |
| WP:WP5115 | 0.0114539669178 | 0.333333333333 | TBK1 CXCL1 TRAF2 | Network map of SARS CoV 2 signaling pathway |
| WP:WP5406 | 0.011530250377 | 0.222222222222 | TRAF2 TRAF1 | 13q12 12 copy number variation |
| WP:WP4880 | 0.012380386891 | 0.222222222222 | TBK1 IKBKE | Host pathogen interaction of human coronaviruses interferon induction |
| WP:WP5038 | 0.012380386891 | 0.222222222222 | TBK1 IKBKE | Mitochondrial immune response to SARS CoV 2 |
| WP:WP4912 | 0.0132604628613 | 0.222222222222 | TBK1 IKBKE | SARS coronavirus and innate immunity |
| WP:WP3941 | 0.0191680266266 | 0.222222222222 | TRAF2 TRAF1 | Oxidative damage response |
| GO:0140546 | 0.0304474002823 | 0.666666666667 | IKBKE TANK CXCL1 TRAF2 TBK1 BIRC3 | defense response to symbiont |
| WP:WP2018 | 0.0313898659069 | 0.222222222222 | TRAF2 TRAF1 | RANKL RANK signaling pathway |
| REAC:R-HSA-168256 | 0.0342353908338 | 0.666666666667 | IKBKE TANK CXCL1 TRAF2 TBK1 BIRC3 | Immune System |
| REAC:R-HSA-5675482 | 0.0344394959621 | 0.222222222222 | BIRC3 TRAF2 | Regulation of necroptotic cell death |
| REAC:R-HSA-5213460 | 0.0344394959621 | 0.222222222222 | BIRC3 TRAF2 | RIPK1-mediated regulated necrosis |
| GO:0071356 | 0.0352688611428 | 0.444444444444 | BIRC3 TRAF1 TRAF2 TANK | cellular response to tumor necrosis factor |
| KEGG:04623 | 0.0402734932484 | 0.222222222222 | TBK1 IKBKE | Cytosolic DNA-sensing pathway |
| KEGG:05014 | 0.0415121242062 | 0.333333333333 | TANK TRAF2 TBK1 | Amyotrophic lateral sclerosis |
| REAC:R-HSA-936440 | 0.0417623735111 | 0.222222222222 | TBK1 IKBKE | Negative regulators of DDX58/IFIH1 signaling |
| GO:1902531 | 0.0430383681752 | 0.777777777778 | TANK IKBKE HTRA2 TRAF1 TBK1 BIRC3 TRAF2 | regulation of intracellular signal transduction |
| REAC:R-HSA-5357801 | 0.0432202306835 | 0.333333333333 | BIRC3 DIABLO TRAF2 | Programmed Cell Death |
| GO:0042221 | 0.0471112496826 | 0.888888888889 | TANK IKBKE CXCL1 HTRA2 TRAF2 TBK1 BIRC3 TRAF1 | response to chemical |
| GO:0098542 | 0.0476805715431 | 0.666666666667 | IKBKE TANK CXCL1 TRAF2 TBK1 BIRC3 | defense response to other organism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TRAF2 | TRAF1 | 1.0 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | TRAF1 | 0.999 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | TRAF2 | 0.999 | 0.148952380952 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TRAF1 | TBK1 | 0.999 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | TBK1 | 0.998 | 0.194 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| TRAF2 | TBK1 | 0.998 | 0.06 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| TRAF2 | DIABLO | 0.996 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| HTRA2 | TRAF2 | 0.994 | 0.034 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| TANK | DIABLO | 0.993 | 0.128 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| CXCL1 | TRAF2 | 0.987 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TRAF1 | DIABLO | 0.986 | 0.168 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CXCL1 | TBK1 | 0.984 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TANK | IKBKE | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| HTRA2 | TRAF1 | 0.98 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TRAF2 | IKBKE | 0.976 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HTRA2 | DIABLO | 0.973 | 0.374 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| BIRC3 | TRAF2 | 0.969 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | TRAF1 | 0.966 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | DIABLO | 0.964 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HTRA2 | TANK | 0.952 | 0.096 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| CXCL1 | DIABLO | 0.952 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | IKBKE | 0.892 | bioplex3_WMM WMM_only | |
| TBK1 | DIABLO | 0.858 | 0.052 | youn () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| TRAF1 | IKBKE | 0.796 | bioplex3_WMM WMM_only | |
| IKBKE | TBK1 | 0.456 | bioplex3_WMM WMM_only | |
| HTRA2 | IKBKE | 0.451 | bioplex3_WMM WMM_only | |
| BIRC3 | TANK | 0.384 | bioplex3_WMM WMM_only | |
| IKBKE | DIABLO | 0.374 | bioplex3_WMM WMM_only | |
| BIRC3 | TBK1 | 0.373 | bioplex3_WMM WMM_only | |
| BIRC3 | HTRA2 | 0.306 | bioplex3_WMM WMM_only | |
| HTRA2 | TBK1 | 0.277 | 0.042 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CXCL1 | TANK | 0.043 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes