hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06259.1
Complex Portal: CPX-18521
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HOXA6 | Homeobox protein Hox-A6 (Homeobox protein Hox-1B) | 4 | UniProt NCBI |
| RNASE2 | Non-secretory ribonuclease (EC 4.6.1.18) (Eosinophil-derived neurotoxin) (RNase UpI-2) (Ribonuclease 2) (RNase 2) (Ribonuclease US) | 5 | UniProt NCBI |
| RNASE4 | Ribonuclease 4 (RNase 4) (EC 3.1.27.-) | 5 | UniProt NCBI |
| RNH1 | Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI) | 5 | UniProt NCBI |
| HOXA4 | Homeobox protein Hox-A4 (Homeobox protein Hox-1.4) (Homeobox protein Hox-1D) | 5 | UniProt NCBI |
| HOXB4 | Homeobox protein Hox-B4 (Homeobox protein Hox-2.6) (Homeobox protein Hox-2F) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0009952 | 0.00549374094772 | 1.0 | HOXB4 HOXA6 HOXA4 | anterior/posterior pattern specification |
| REAC:R-HSA-5619507 | 0.0377646799279 | 0.666666666667 | HOXA4 HOXB4 | Activation of HOX genes during differentiation |
| REAC:R-HSA-5617472 | 0.0377646799279 | 0.666666666667 | HOXA4 HOXB4 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RNASE4 | RNH1 | 0.998 |
mutually_exclusive (P03950)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RNH1 | HOXB4 | 0.998 | 0.114 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RNH1 | HOXA4 | 0.97 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RNASE2 | RNH1 | 0.967 | 0.082 |
mutually_exclusive (P12724)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| HOXA6 | RNH1 | 0.959 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RNASE4 | HOXB4 | 0.933 |
mutually_exclusive (P13489)
|
bioplex3_WMM WMM_only | |
| HOXA6 | HOXB4 | 0.415 | bioplex3_WMM WMM_only | ||
| HOXA4 | HOXB4 | 0.415 | bioplex3_WMM WMM_only | ||
| HOXA6 | HOXA4 | 0.415 | bioplex3_WMM WMM_only | ||
| RNASE4 | HOXA6 | 0.278 | bioplex3_WMM WMM_only | ||
| RNASE4 | HOXA4 | 0.278 |
mutually_exclusive (P13489)
|
bioplex3_WMM WMM_only |
Related Complexes