hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06267.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TP53 | Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) | 5 | UniProt NCBI |
| CUL7 | Cullin-7 (CUL-7) | 5 | UniProt NCBI |
| CCDC183 | Coiled-coil domain-containing protein 183 | 3 | UniProt NCBI |
| CUL9 | Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6577 | 2.45511732198e-08 | 0.75 | TP53 CUL9 CUL7 | 3M complex |
| WP:WP4284 | 0.0248784837172 | 0.25 | TP53 | Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer |
| CORUM:2681 | 0.0249718442456 | 0.25 | TP53 | p53 homotetramer complex |
| CORUM:5811 | 0.0249718442456 | 0.25 | TP53 | p53-BCL2 complex |
| WP:WP4399 | 0.0373138951921 | 0.25 | TP53 | MicroRNA network associated with chronic lymphocytic leukemia |
| CORUM:2678 | 0.049938562206 | 0.25 | TP53 | FOXO3-TP53 complex, oxidative stress stimulated |
| CORUM:2679 | 0.049938562206 | 0.25 | TP53 | p53-SP1 complex |
| CORUM:2821 | 0.049938562206 | 0.25 | TP53 | hSIR2-p53 complex |
| CORUM:5288 | 0.049938562206 | 0.25 | TP53 | P53-BARD1-KU70 complex |
| CORUM:5331 | 0.049938562206 | 0.25 | TP53 | YY1-MDM2-p53 complex |
| CORUM:5812 | 0.049938562206 | 0.25 | TP53 | p53-BCL2 complex |
| CORUM:7180 | 0.049938562206 | 0.25 | TP53 | p53-MDM2 complex |
| CORUM:7420 | 0.049938562206 | 0.25 | TP53 | TP53-TSPY1-USP7 complex |
| REAC:R-HSA-9723907 | 0.0499436884912 | 0.25 | TP53 | Loss of Function of TP53 in Cancer |
| REAC:R-HSA-9723905 | 0.0499436884912 | 0.25 | TP53 | Loss of function of TP53 in cancer due to loss of tetramerization ability |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CUL7 | CUL9 | 0.999 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TP53 | CUL9 | 0.997 | 0.658421901077 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CUL7 | TP53 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CUL7 | CCDC183 | 0.982 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CCDC183 | CUL9 | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CCDC183 | TP53 | 0.013 | youn_WMM WMM_only |
Related Complexes