hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06271.1
Complex Portal: CPX-20871
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RPUSD3 | Mitochondrial mRNA pseudouridine synthase RPUSD3 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 3) | 5 | UniProt NCBI |
| RCC1L | RCC1-like G exchanging factor-like protein (RCC1-like) (Williams-Beuren syndrome chromosomal region 16 protein) | 5 | UniProt NCBI |
| NGRN | Neugrin (Mesenchymal stem cell protein DSC92) (Neurite outgrowth-associated protein) (Spinal cord-derived protein FI58G) | 5 | UniProt NCBI |
| NME6 | Nucleoside diphosphate kinase 6 (NDK 6) (NDP kinase 6) (EC 2.7.4.6) (Inhibitor of p53-induced apoptosis-alpha) (IPIA-alpha) (nm23-H6) | 5 | UniProt NCBI |
| FASTKD2 | FAST kinase domain-containing protein 2, mitochondrial | 5 | UniProt NCBI |
| DDX28 | Probable ATP-dependent RNA helicase DDX28 (EC 3.6.4.13) (Mitochondrial DEAD box protein 28) | 5 | UniProt NCBI |
| PTCD1 | Pentatricopeptide repeat-containing protein 1, mitochondrial | 5 | UniProt NCBI |
| PIGY | Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y (Phosphatidylinositol-glycan biosynthesis class Y protein) (PIG-Y) | 5 | UniProt NCBI |
| MCAT | Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCT) (EC 2.3.1.39) (Mitochondrial malonyl CoA:ACP acyltransferase) (Mitochondrial malonyltransferase) ([Acyl-carrier-protein] malonyltransferase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0070131 | 4.51189669214e-06 | 0.444444444444 | RCC1L RPUSD3 FASTKD2 NGRN | positive regulation of mitochondrial translation |
| GO:0070129 | 2.41328111219e-05 | 0.444444444444 | RCC1L RPUSD3 FASTKD2 NGRN | regulation of mitochondrial translation |
| GO:0062125 | 2.92053987194e-05 | 0.444444444444 | RCC1L RPUSD3 FASTKD2 NGRN | regulation of mitochondrial gene expression |
| CORUM:6308 | 0.000273361732609 | 0.222222222222 | DDX28 FASTKD2 | protein complex (DDX28; DHX30; GRSF1; FASTKD2; FASTKD5) |
| GO:0019843 | 0.000488457397695 | 0.444444444444 | RCC1L DDX28 NGRN FASTKD2 | rRNA binding |
| GO:0061668 | 0.000966803032193 | 0.333333333333 | DDX28 NGRN FASTKD2 | mitochondrial ribosome assembly |
| GO:0005739 | 0.00141748309457 | 0.888888888889 | NME6 RPUSD3 PTCD1 FASTKD2 DDX28 RCC1L NGRN MCAT | mitochondrion |
| GO:0045727 | 0.0179204158456 | 0.444444444444 | RCC1L RPUSD3 FASTKD2 NGRN | positive regulation of translation |
| GO:0032543 | 0.0310808183133 | 0.444444444444 | RCC1L RPUSD3 FASTKD2 NGRN | mitochondrial translation |
| GO:0034250 | 0.0352688611428 | 0.444444444444 | RCC1L RPUSD3 FASTKD2 NGRN | positive regulation of amide metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RPUSD3 | FASTKD2 | 0.998 | 0.35 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RCC1L | NME6 | 0.998 | 0.242 |
mutually_exclusive (O95900)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| FASTKD2 | DDX28 | 0.998 | 0.344 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| RPUSD3 | PTCD1 | 0.996 | 0.316 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RCC1L | FASTKD2 | 0.995 | 0.138 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NGRN | RCC1L | 0.995 | 0.294 |
structurally_consistent (Q9Y2Z4)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| MCAT | DDX28 | 0.994 | 0.208 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PTCD1 | RCC1L | 0.993 | 0.184 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NGRN | FASTKD2 | 0.993 | 0.076 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| RPUSD3 | RCC1L | 0.991 | 0.478 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| NGRN | MCAT | 0.99 | 0.308 |
structurally_consistent (Q9Y2Z4)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RPUSD3 | NGRN | 0.987 | 0.224 |
structurally_consistent (Q9NYY8)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| MCAT | RCC1L | 0.982 | 0.279333333333 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NGRN | PTCD1 | 0.98 | 0.162 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| MCAT | FASTKD2 | 0.98 | 0.06 |
structurally_consistent (Q96CM3)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RCC1L | PIGY | 0.98 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RPUSD3 | MCAT | 0.979 | 0.342 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RCC1L | DDX28 | 0.976 | 0.322 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NGRN | DDX28 | 0.975 | 0.114 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| PTCD1 | FASTKD2 | 0.961 | 0.362 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM treiber_WMM | |
| PTCD1 | DDX28 | 0.961 | 0.366 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM treiber_WMM | |
| RPUSD3 | DDX28 | 0.951 | 0.566 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MCAT | PTCD1 | 0.946 | 0.074 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NME6 | PIGY | 0.892 | bioplex3_WMM WMM_only | ||
| MCAT | PIGY | 0.188 | bioplex3_WMM WMM_only | ||
| MCAT | NME6 | 0.082 | 0.152 | bioplex3_WMM WMM_only | |
| NME6 | FASTKD2 | 0.025 | 0.116 | bioplex_WMM bioplex3_WMM WMM_only | |
| RPUSD3 | NME6 | 0.023 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only | |
| NGRN | NME6 | 0.019 | 0.162 | bioplex3_WMM WMM_only | |
| PTCD1 | PIGY | 0.016 | bioplex3_WMM WMM_only | ||
| NGRN | PIGY | 0.013 | bioplex3_WMM WMM_only | ||
| PTCD1 | NME6 | 0.009 | 0.236 | bioplex3_WMM WMM_only | |
| NME6 | DDX28 | 0.005 | 0.178 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes