hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06278.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GINS2 | DNA replication complex GINS protein PSF2 (GINS complex subunit 2) | 5 | UniProt NCBI |
| CDC45 | Cell division control protein 45 homolog (PORC-PI-1) | 5 | UniProt NCBI |
| GINS3 | DNA replication complex GINS protein PSF3 (GINS complex subunit 3) | 5 | UniProt NCBI |
| GINS1 | DNA replication complex GINS protein PSF1 (GINS complex subunit 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-176974 | 4.75355925165e-11 | 1.0 | GINS3 GINS1 GINS2 CDC45 | Unwinding of DNA |
| CORUM:678 | 2.80628050973e-09 | 0.75 | GINS3 GINS2 GINS1 | GINS complex |
| REAC:R-HSA-69190 | 3.4532927412e-09 | 1.0 | GINS3 GINS1 GINS2 CDC45 | DNA strand elongation |
| GO:0071162 | 8.68316823302e-09 | 1.0 | GINS3 GINS1 GINS2 CDC45 | CMG complex |
| GO:0031261 | 1.30247523495e-08 | 1.0 | GINS3 GINS1 GINS2 CDC45 | DNA replication preinitiation complex |
| GO:0006268 | 1.5748109659e-07 | 1.0 | GINS3 GINS1 GINS2 CDC45 | DNA unwinding involved in DNA replication |
| REAC:R-HSA-69239 | 7.62562229922e-07 | 1.0 | GINS3 GINS1 GINS2 CDC45 | Synthesis of DNA |
| GO:0000811 | 1.53784171933e-06 | 0.75 | GINS3 GINS2 GINS1 | GINS complex |
| REAC:R-HSA-69242 | 2.46195966239e-06 | 1.0 | GINS3 GINS1 GINS2 CDC45 | S Phase |
| REAC:R-HSA-69306 | 3.54260213226e-06 | 1.0 | GINS3 GINS1 GINS2 CDC45 | DNA Replication |
| GO:0032508 | 3.92045045721e-06 | 1.0 | GINS3 GINS1 GINS2 CDC45 | DNA duplex unwinding |
| GO:0032392 | 7.70499617526e-06 | 1.0 | GINS3 GINS1 GINS2 CDC45 | DNA geometric change |
| GO:0071103 | 1.28309598221e-05 | 1.0 | GINS3 GINS1 GINS2 CDC45 | DNA conformation change |
| GO:1902969 | 0.000109904886398 | 0.75 | GINS3 CDC45 GINS1 | mitotic DNA replication |
| REAC:R-HSA-69278 | 0.000302817168596 | 1.0 | GINS3 GINS1 GINS2 CDC45 | Cell Cycle, Mitotic |
| GO:0006261 | 0.000415139510394 | 1.0 | GINS3 GINS1 GINS2 CDC45 | DNA-templated DNA replication |
| REAC:R-HSA-1640170 | 0.000694680089617 | 1.0 | GINS3 GINS1 GINS2 CDC45 | Cell Cycle |
| GO:0000228 | 0.000948358662764 | 1.0 | GINS3 GINS1 GINS2 CDC45 | nuclear chromosome |
| GO:0033260 | 0.00209449363787 | 0.75 | GINS3 CDC45 GINS1 | nuclear DNA replication |
| GO:0006260 | 0.00227782697336 | 1.0 | GINS3 GINS1 GINS2 CDC45 | DNA replication |
| GO:0044786 | 0.00298219742351 | 0.75 | GINS3 CDC45 GINS1 | cell cycle DNA replication |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GINS3 | GINS1 | 1.0 | 0.93 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction |
| GINS2 | GINS1 | 1.0 | 0.838 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction |
| GINS2 | GINS3 | 1.0 | 0.908 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction |
| GINS3 | CDC45 | 0.984 | 0.474 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GINS1 | CDC45 | 0.976 | 0.316 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| GINS2 | CDC45 | 0.857 | 0.124 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes