hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06280.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LEP | Leptin (Obese protein) (Obesity factor) | 5 | UniProt NCBI |
| LEPR | Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5400 | 1.53229326573e-05 | 1.0 | LEP LEPR | 6q16 copy number variation |
| WP:WP3934 | 1.91536658216e-05 | 1.0 | LEP LEPR | Leptin and adiponectin |
| WP:WP3935 | 5.10764421909e-05 | 1.0 | LEP LEPR | Leptin insulin signaling overlap |
| HP:0410035 | 5.12628525639e-05 | 1.0 | LEP LEPR | Abnormal T cell activation |
| HP:0005419 | 5.12628525639e-05 | 1.0 | LEP LEPR | Decreased T cell activation |
| HP:0003292 | 0.000187963792734 | 1.0 | LEP LEPR | Decreased serum leptin |
| HP:0004361 | 0.000266566833332 | 1.0 | LEP LEPR | Abnormal circulating leptin concentration |
| HP:0004926 | 0.000310994638887 | 1.0 | LEP LEPR | Orthostatic hypotension due to autonomic dysfunction |
| KEGG:04920 | 0.000317498613307 | 1.0 | LEP LEPR | Adipocytokine signaling pathway |
| WP:WP1403 | 0.000778915743411 | 1.0 | LEP LEPR | AMP activated protein kinase signaling |
| HP:0500267 | 0.000943236487175 | 1.0 | LEP LEPR | Abnormal proportion of CD4-positive helper T cells |
| HP:0005407 | 0.000943236487175 | 1.0 | LEP LEPR | Decreased proportion of CD4-positive helper T cells |
| WP:WP2034 | 0.000969601127591 | 1.0 | LEP LEPR | Leptin signaling pathway |
| KEGG:04152 | 0.00102874102663 | 1.0 | LEP LEPR | AMPK signaling pathway |
| HP:0008187 | 0.00111069513888 | 1.0 | LEP LEPR | Absence of secondary sex characteristics |
| KEGG:04630 | 0.00138428094844 | 1.0 | LEP LEPR | JAK-STAT signaling pathway |
| HP:0032218 | 0.00148662272435 | 1.0 | LEP LEPR | Decreased proportion of CD4-positive T cells |
| KEGG:04932 | 0.00155920593969 | 1.0 | LEP LEPR | Non-alcoholic fatty liver disease |
| HP:0000831 | 0.00158914842948 | 1.0 | LEP LEPR | Insulin-resistant diabetes mellitus |
| HP:0008245 | 0.00169509165811 | 1.0 | LEP LEPR | Pituitary hypothyroidism |
| HP:0001278 | 0.00191723068589 | 1.0 | LEP LEPR | Orthostatic hypotension |
| HP:0031392 | 0.00215303980768 | 1.0 | LEP LEPR | Abnormal proportion of CD4-positive T cells |
| HP:0008214 | 0.00240251902349 | 1.0 | LEP LEPR | Decreased serum estradiol |
| KEGG:04080 | 0.00282724955659 | 1.0 | LEP LEPR | Neuroactive ligand-receptor interaction |
| KEGG:04060 | 0.0031385705215 | 1.0 | LEP LEPR | Cytokine-cytokine receptor interaction |
| HP:0025132 | 0.00353713682691 | 1.0 | LEP LEPR | Abnormal circulating estrogen level |
| HP:0011840 | 0.00353713682691 | 1.0 | LEP LEPR | Abnormality of T cell physiology |
| HP:0025133 | 0.00353713682691 | 1.0 | LEP LEPR | Abnormal serum estradiol |
| HP:0000815 | 0.0038549665128 | 1.0 | LEP LEPR | Hypergonadotropic hypogonadism |
| HP:0040171 | 0.0038549665128 | 1.0 | LEP LEPR | Decreased serum testosterone concentration |
| HP:0005403 | 0.0038549665128 | 1.0 | LEP LEPR | T lymphocytopenia |
| WP:WP4396 | 0.00396523446209 | 1.0 | LEP LEPR | Nonalcoholic fatty liver disease |
| HP:0030349 | 0.00418646629272 | 1.0 | LEP LEPR | Decreased circulating androgen concentration |
| HP:0002591 | 0.00526298619656 | 1.0 | LEP LEPR | Polyphagia |
| HP:0025540 | 0.00564916635254 | 1.0 | LEP LEPR | Abnormal T cell subset distribution |
| HP:0005616 | 0.00584738271579 | 1.0 | LEP LEPR | Accelerated skeletal maturation |
| HP:0011787 | 0.00604901660254 | 1.0 | LEP LEPR | Central hypothyroidism |
| HP:0030087 | 0.00625406801279 | 1.0 | LEP LEPR | Abnormal circulating testosterone concentration |
| HP:0008724 | 0.00801751014099 | 1.0 | LEP LEPR | Hypoplasia of the ovary |
| HP:0010462 | 0.00849254590808 | 1.0 | LEP LEPR | Aplasia/Hypoplasia of the ovary |
| HP:0030347 | 0.00849254590808 | 1.0 | LEP LEPR | Abnormal circulating androgen level |
| HP:0000771 | 0.00948362772432 | 1.0 | LEP LEPR | Gynecomastia |
| GO:0098868 | 0.00983221512175 | 1.0 | LEP LEPR | bone growth |
| HP:0002615 | 0.0113495955576 | 1.0 | LEP LEPR | Hypotension |
| HP:0033799 | 0.0124910484081 | 1.0 | LEP LEPR | Abnormal circulating sex hormone concentration |
| HP:0000855 | 0.0130822799743 | 1.0 | LEP LEPR | Insulin resistance |
| HP:0011839 | 0.0130822799743 | 1.0 | LEP LEPR | Abnormal T cell count |
| GO:0033210 | 0.0131096201623 | 1.0 | LEP LEPR | leptin-mediated signaling pathway |
| HP:0002843 | 0.0139947587499 | 1.0 | LEP LEPR | Abnormal T cell morphology |
| HP:0000786 | 0.0146201655512 | 1.0 | LEP LEPR | Primary amenorrhea |
| HP:0100738 | 0.0152592424465 | 1.0 | LEP LEPR | Abnormal eating behavior |
| GO:0044320 | 0.016855225923 | 1.0 | LEP LEPR | cellular response to leptin stimulus |
| HPA:0120233 | 0.0175888206245 | 0.5 | LEPR | choroid plexus; ependymal cells[High] |
| HP:0002155 | 0.0179522509679 | 1.0 | LEP LEPR | Hypertriglyceridemia |
| HP:0012332 | 0.0183042558888 | 1.0 | LEP LEPR | Abnormal autonomic nervous system physiology |
| HP:0000842 | 0.0227948817734 | 1.0 | LEP LEPR | Hyperinsulinemia |
| CORUM:1992 | 0.0249718442457 | 0.5 | LEPR | LEPR homodimer complex |
| HP:0040214 | 0.0252247409849 | 1.0 | LEP LEPR | Abnormal circulating insulin concentration |
| HP:0003077 | 0.0277776310426 | 1.0 | LEP LEPR | Hyperlipidemia |
| GO:0044321 | 0.0309012475255 | 1.0 | LEP LEPR | response to leptin |
| HP:0008734 | 0.0323058496858 | 1.0 | LEP LEPR | Decreased testicular size |
| HP:0031065 | 0.033730956987 | 1.0 | LEP LEPR | Abnormal ovarian morphology |
| HP:0000830 | 0.0346981161387 | 1.0 | LEP LEPR | Anterior hypopituitarism |
| HPA:0120000 | 0.0351752340474 | 0.5 | LEPR | choroid plexus |
| HPA:0120231 | 0.0351752340474 | 0.5 | LEPR | choroid plexus; ependymal cells[>=Low] |
| HPA:0120232 | 0.0351752340474 | 0.5 | LEPR | choroid plexus; ependymal cells[>=Medium] |
| HP:0002788 | 0.0351868219998 | 1.0 | LEP LEPR | Recurrent upper respiratory tract infections |
| HP:0000141 | 0.0371758206793 | 1.0 | LEP LEPR | Amenorrhea |
| HP:0001888 | 0.0376816141579 | 1.0 | LEP LEPR | Lymphopenia |
| HP:0040075 | 0.0381908251601 | 1.0 | LEP LEPR | Hypopituitarism |
| HP:0001739 | 0.0397389633075 | 1.0 | LEP LEPR | Abnormal nasopharynx morphology |
| HP:0010468 | 0.0418509928331 | 1.0 | LEP LEPR | Aplasia/Hypoplasia of the testes |
| HP:0033151 | 0.0468029843908 | 1.0 | LEP LEPR | Abnormal pharynx morphology |
| HP:0045058 | 0.0496737041344 | 1.0 | LEP LEPR | Abnormality of the testis size |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LEPR | LEP | 0.997 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| LEP | huMAP3_01484.1 huMAP3_06280.1 huMAP3_08004.1 huMAP3_14276.1 huMAP3_14633.1 |
| LEPR | huMAP3_00554.1 huMAP3_06280.1 huMAP3_08004.1 huMAP3_14276.1 huMAP3_14616.1 huMAP3_14633.1 |