hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06287.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HLTF | Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) | 5 | UniProt NCBI |
| XPC | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | 5 | UniProt NCBI |
| RNF146 | E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146) | 5 | UniProt NCBI |
| PARP2 | Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5696394 | 0.00718390333861 | 0.5 | PARP2 XPC | DNA Damage Recognition in GG-NER |
| REAC:R-HSA-5696395 | 0.008795277704 | 0.5 | PARP2 XPC | Formation of Incision Complex in GG-NER |
| WP:WP4946 | 0.0159973744593 | 0.5 | PARP2 XPC | DNA repair pathways full network |
| REAC:R-HSA-5696399 | 0.0346321697685 | 0.5 | PARP2 XPC | Global Genome Nucleotide Excision Repair (GG-NER) |
| GO:0072572 | 0.042122686785 | 0.5 | PARP2 RNF146 | poly-ADP-D-ribose binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RNF146 | PARP2 | 0.999 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| XPC | PARP2 | 0.993 | 0.032 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| XPC | RNF146 | 0.984 | 0.182 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| HLTF | XPC | 0.984 | 0.032 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| HLTF | RNF146 | 0.903 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| HLTF | PARP2 | 0.654 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes